Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy Academic Article uri icon

abstract

  • The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific 'photopotent' subcellular sites.

authors

  • Woodburn, KW
  • Hill, JS
  • Stylli, S
  • Kaye, AH
  • Reiss, JA
  • Phillips, DR

publication date

  • September 1994