Biodistribution of haematoporphyrin analogues in a lung carcinoma model Academic Article uri icon

abstract

  • In an attempt to identify novel compounds useful for the optimization of Photodynamic Therapy (PDT), the tissue localization of new synthetic porphyrins was compared with Photofrin II in nude mice xenografted with a human small cell lung cancer (POVD). Three haematoporphyrin analogues were selected for this study based on prior in vitro photosensitivity screening of a series of 15 such derivatives, as well as on the basis of improved localization in C6 gliomas in mice. Two of the porphyrins yielded better tumour:normal lung ratios than Photofrin II and, of these two, one (P13) is known to exhibit good photosensitization properties both in vitro and in vivo, and is therefore a good candidate as a lead compound for the development of porphyrins suitable for the photodynamic treatment of lung tumours.

authors

  • Tronconi, Marco
  • Colombo, Ambrogio
  • De Cesare, Michelandrea
  • Marchesini, Renato
  • Woodburn, Kathryn W
  • Reiss, James A
  • Phillips, Don R
  • Zunino, Franco

publication date

  • January 1995