The fusion partner specifies the oncogenic potential of NUP98 fusion proteins Academic Article uri icon

abstract

  • NUP98 is among the most promiscuously translocated genes in hematological diseases. Among the 28 known fusion partners, there are two categories: homeobox genes and non-homeobox genes. The homeobox fusion partners are well-studied in animal models, resulting in HoxA cluster overexpression and hematological disease. The non-homeobox fusion partners are less well studied. We created transgenic animal models for three NUP98 fusion genes (one homeobox, two non-homeobox), and show that in this system, the NUP98-homeobox fusion promotes self-renewal and aberrant gene expression to a significantly greater extent. We conclude that homeobox partners create more potent NUP98 fusion oncogenes than do non-homeobox partners.

authors

  • Saw, J
  • Curtis, DJ
  • Hussey, DJ
  • Dobrovic, A
  • Aplan, PD
  • Slape, CI

publication date

  • 2013