Complete molecular response of e6a2 BCR-ABL-positive acute myeloid leukemia to imatinib then dasatinib Academic Article uri icon

abstract

  • De novo presentation of acute myeloid leukemia (AML) expressing the Philadelphia (Ph) chromosomal abnormality is rare and is associated with a dismal prognosis. To date, reported cases of Ph(+) AML have expressed either the e13a2 or e14a2 BCR-ABL fusion transcripts. We report a unique case of de novo AML expressing the e6a2 fusion transcript and describe disease sensitivity to both imatinib before allogeneic stem-cell transplantation and dasatinib for AML relapse after allogeneic stem-cell transplantation. Furthermore, we report that sustained molecular remission has been achieved despite withdrawal of tyrosine kinase inhibitor (TKI) therapy.

authors

  • Ritchie, DS
  • McBean, M
  • Westerman, DA
  • Kovalenko, S
  • Seymour, JF
  • Dobrovic, A

publication date

  • March 1, 2008

published in