New role for the (pro)renin receptor in T-cell development Academic Article uri icon

abstract

  • The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin system. However, it is now emerging that PRR has instead a generic role in cellular development. Here, we have specifically deleted PRR from T cells. T-cell-specific PRR-knockout mice had a significant decrease in thymic cellularity, corresponding with a 100-fold decrease in the number of CD4(+) and CD8(+) thymocytes, and a large increase in double-negative (DN) precursors. Gene expression analysis on sorted DN3 thymocytes indicated that PRR-deficient thymocytes have perturbations in key cellular pathways essential at the DN3 stage, including transcription and translation. Further characterization of DN T-cell progenitors leads us to propose that PRR deletion affects thymocyte survival and development at multiple stages; from DN3 through to DN4, double-positive, and single-positive CD4 and CD8. Our study thus identifies a new role for PRR in T-cell development.

authors

  • Geisberger, S
  • Maschke, U
  • Gebhardt, M
  • Kleinewietfeld, M
  • Manzel, A
  • Linker, RA
  • Chidgey, A
  • Dechend, R
  • Nguyen, G
  • Daumke, O
  • Muller, DN
  • Wright, MD
  • Binger, KJ

publication date

  • 2015

published in