Changes in developing behavior following prenatal administration of imipramine Academic Article uri icon


  • Female rats were given oral doses of Imipramine (5mg/kg) from 14-21 days prior to mating to conception or Day 19 or gestation and the physical maturation and behavioral development of their offspring was compared with that of controls. There were significant differences between the weights of the Imipramine and control animals at 21 days and the appearance of some reflexes was delayed. Behavior in an open field was observed when the rats were 9, 13, 17 and 21 days of age and it was found that exploratory responses were less frequent in the drug exposed offspring. In contrast there were no obvious physical anomalies and the adult behavior of the Imipramine animals on a spontaneous alternation task and a swimming maze did not differ from that of controls.

publication date

  • September 1975