A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy Academic Article uri icon

abstract

  • A novel and potent nuclear factor erythroid-2 related factor 2 (Nrf2) activator, dh404, attenuates retinal vasculopathy by reducing oxidative stress-mediated damage to glia. Nrf2 agonists represent an effective strategy to improve vision-threatening glial and vascular cell pathology in ischaemic retinopathies.

authors

  • Deliyanti, D
  • Lee, JY
  • Petratos, S
  • Meyer, CJ
  • Ward, KW
  • Wilkinson-Berka, JL
  • de Haan, Judy B

publication date

  • 2016

has subject area