Modeling Biological Activities of Nanoparticles Academic Article uri icon

abstract

  • Products are increasingly incorporating nanomaterials, but we have a poor understanding of their adverse effects. To assess risk, regulatory authorities need more experimental testing of nanoparticles. Computational models play a complementary role in allowing rapid prediction of potential toxicities of new and modified nanomaterials. We generated quantitative, predictive models of cellular uptake and apoptosis induced by nanoparticles for several cell types. We illustrate the potential of computational methods to make a contribution to nanosafety.

authors

  • Epa, VC
  • Burden, FR
  • Tassa, C
  • Weissleder, R
  • Shaw, S
  • Winkler, DA
  • Winkler, D

publication date

  • 2012