Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea) Academic Article uri icon


  • A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites.


  • Ali, Abdelselam
  • Bliese, Marianne
  • Rasmussen, Jo-Anne M
  • Sargent, Roger M
  • Saubern, Simon
  • Sawutz, David G
  • Wilkie, John S
  • Winkler, David A
  • Winzenberg, Kevin N
  • Woodgate, Ruth CJ

publication date

  • February 2007