QSAR studies of hydrazone uncouplers of oxidative phosphorylation Academic Article uri icon


  • Semiempirical molecular orbital calculations have been performed on a series of hydrazone uncouplers of mitochondrial oxidative phosphorylation which show insecticidal activity. Regression analysis yielded significant correlations between uncoupling activity, insecticidal potency and such physicochemical or theoretically-derived parameters as lipophilicity, pKa and atom charges.


  • Winkler, DA
  • Holan, G
  • Smith, DRJ
  • Middleton, EJ
  • Hart, NK
  • Rihs, K
  • Smith, KW

publication date

  • January 1, 1988