Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: review of randomized controlled trials from 1997 to 2017 Academic Article uri icon

abstract

  • Objective.To assess the uptake of the OMERACT-OARSI (Outcome Measures in Rheumatology- Osteoarthritis Research Society International) core outcome set (COS) domains in hip and/or knee osteoarthritis (OA) trials.Methods.There were 382 trials of hip and/or knee OA identified from the ClinicalTrial.gov registry from 1997 to 2017. Frequency of COS adoption was assessed by year and per 5-yearly phases.Results.COS adoption decreased from 61% between 1997 and 2001 to 38% between 2012 and 2016. Pain (95%) and physical function (86%) were most consistently adopted. Patient’s global assessment (48%) was the principal missing domain.Conclusion.Limited adoption of the COS domains indicates that further consideration to improve uptake is required.

authors

  • Smith, Toby O
  • Mansfield, Michael
  • Hawker, Gillian A
  • Hunter, David J
  • March, Lyn M
  • Boers, Maarten
  • Shea, Beverley J
  • Christensen, Robin
  • Guillemin, Francis
  • Terwee, Caroline B
  • Williamson, Paula R
  • Roos, Ewa M
  • Loeser, Richard F
  • Schnitzer, Thomas J
  • Kloppenburg, Margreet
  • Neogi, Tuhina
  • Ladel, Christoph H
  • Kalsi, Gurdyal
  • Kaiser, Ulrike
  • Buttel, Thomas W
  • Ashford, Anne E
  • Mobasheri, Ali
  • Ardene, Nigel K
  • Tennant, Alan
  • Hochberg, Marc C
  • de Witel, Maarten
  • Tugwell, Peter
  • Conaghan, Philip G

publication date

  • 2019