Exercise training reduces myocardial lipid peroxidation following short-term ischemia-reperfusion Academic Article uri icon

abstract

  • PURPOSE:The purpose of these experiments was to test the hypothesis that endurance exercise training will reduce myocardial lipid peroxidation following short-term ischemia and reperfusion (I-R). METHODS:Female Sprague-Dawley rats (4 months old) were randomly assigned to either a sedentary control group (N = 13) or to an exercise training group (N = 13). The exercise trained animals ran 4 d.wk-1 (90 min.d-1) at approximately 75% V02max. Following a 10-wk training program, animals were anesthetized, mechanically ventilated, and the chest was opened by thoracotomy. Coronary occlusion was achieved by a ligature around the left coronary artery; occlusion was maintained for 5 min followed by a 10-min period of reperfusion. RESULTS:Although training did not alter (P > 0.05) myocardial activities of antioxidant enzymes (superoxide dismutase and glutathione peroxidase), training was associated with significant increase (P > 0.05) in heat shock protein (HSP72) in the left ventricle. Compared with controls, trained animals exhibited significantly lower levels (P < 0.05) of myocardial lipid peroxidation following I-R. CONCLUSION:These data support the hypothesis that exercise training provides protection against myocardial lipid peroxidation induced by short-term I-R in vivo.

authors

  • Lexis, Louise
  • DEMIREL, HAYDAR A
  • POWERS, SCOTT K
  • CAILLAUD, CORINNE
  • COOMBES, JEFF S
  • NAITO, HISASHI
  • FLETCHER, LOUISE A
  • VRABAS, IANNIS
  • JESSUP, JAMES V
  • JI, LI L

publication date

  • August 1998