Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men: Baseline data from the study of the prevention of anal cancer (SPANC) Academic Article uri icon

abstract

  • BACKGROUND:The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. METHODS:The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology). Logistic regression analyses were performed to assess the association of symptoms with HSIL. RESULTS:Among 414 MSM included (composite-HSIL (n = 231); negative for SIL (n = 183)), 306 (73.9%) reported symptom(s) within the last 6 months. There was no association between any symptom and composite-HSIL. A significant association between anal lump and a larger burden of HSIL (at least 2 intra-anal octants) (anal lump within last month: p = 0.014; anal lump within last 6 months: p = 0.010) became non-significant after adjusting for HIV-status and recent anal warts (anal lump within last month: p = 0.057; anal lump within last 6 months: p = 0.182). CONCLUSIONS:Among MSM age 35 years and older, most anal symptoms are not a useful marker of anal HSIL.

authors

  • Goddard, SL
  • Templeton, DJ
  • Petoumenos, K
  • Jin, F
  • Hillman, RJ
  • Law, C
  • Roberts, JM
  • Fairley, CK
  • Garland, SM
  • Grulich, AE
  • Poynten, IM
  • Farnsworth, Annabelle
  • Biro, Clare
  • Richards, Adele
  • Thurloe, Julia
  • Ekman, Deborah
  • McDonald, Ross
  • Adams, Marjorie
  • Tabrizi, Sepehr
  • Cornall, Alyssa
  • Phillips, Samuel
  • Luque, Monica Molano
  • Comben, Simon
  • McCaffery, Kirsten
  • Howard, Kirsten
  • Kelly, Patrick
  • Seeds, Daniel
  • Carr, Andrew
  • Feeney, Lance
  • Gluyas, Russ
  • Prestage, Garrett
  • Law, Matthew
  • Acraman, Brian
  • McGrath, Patrick
  • Mellor, Robert
  • Pezzopane, Piero
  • Varma, Rick
  • Langton-Lockton, Julian
  • Tong, Winnie

publication date

  • 2019