Voluntary wheel running has beneficial effects in a rat model of CKD-mineral bone disorder (CKD-MBD) Academic Article uri icon


  • BACKGROUND:Reduced bone and muscle health in individuals with CKD contributes to their higher rates of morbidity and mortality. METHODS:We tested the hypothesis that voluntary wheel running would improve musculoskeletal health in a CKD rat model. Rats with spontaneous progressive cystic kidney disease (Cy/+ IU) and normal littermates (NL) were given access to a voluntary running wheel or standard cage conditions for 10 weeks starting at 25 weeks of age when the rats with kidney disease had reached stage 2-3 of CKD. We then measured the effects of wheel running on serum biochemistry, tissue weight, voluntary grip strength, maximal aerobic capacity (VO2max), body composition and bone micro-CT and mechanics. RESULTS:Wheel running improved serum biochemistry with decreased creatinine, phosphorous, and parathyroid hormone in the rats with CKD. It improved muscle strength, increased time-to-fatigue (for VO2max), reduced cortical porosity and improved bone microarchitecture. The CKD rats with voluntary wheel access also had reduced kidney cystic weight and reduced left ventricular mass index. CONCLUSIONS:Voluntary wheel running resulted in multiple beneficial systemic effects in rats with CKD and improved their physical function. Studies examining exercise interventions in patients with CKD are warranted.


  • Avin, KG
  • Allen, MR
  • Chen, NX
  • Srinivasan, S
  • O'Neill, KD
  • Troutman, AD
  • Mast, G
  • Swallow, EA
  • Brown, MB
  • Wallace, JM
  • Zimmers, TA
  • Warden, Stuart J
  • Moe, SM

publication date

  • 2019