Ten male-to-female transsexuals participated in five sessions of oral resonance voice therapy targeting lip spreading and forward tongue carriage. Acoustic analysis of recordings made pre- and posttherapy found that participant formant frequency values (F1, F2, and F3, from the vowels /a/, /i/, and /mho/), as well as fundamental frequency (F0), underwent a general increase posttherapy. F3 values, in particular, increased significantly posttreatment. Trends in listener ratings of these recordings showed that the majority of participants were perceived to sound more feminine following treatment. Participants' self-ratings of their voices pre- and posttreatment also indicated that participants perceived their voices as sounding more feminine and that they were more satisfied with their voices following treatment. The present study supports the findings of previous studies that have demonstrated that resonance characteristics in male-to-female transsexuals can be changed to more closely approximate those of females through oral resonance therapy. This intervention study also demonstrates that a spontaneous increase in F0 is achieved during the course of therapy. Further, this study provides preliminary evidence to suggest that oral resonance therapy may be effective in increasing femininity of voice in male-to-female transsexual clients.