Heparin assisted assembly of somatostatin amyloid nanofibrils results in disordered precipitates by hindrance of protofilaments interactions Academic Article uri icon

abstract

  • We show that the self-assembly of the functional amyloid forming neuropeptide somatostatin-14 is dramatically altered by the presence of GAGs such as heparin and chondroitin sulphate. This work highlights the dangers of using such polymeric sugars as supposedly “inert” amyloid aggregation promotors.

publication date

  • 2018