-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia Academic Article uri icon

abstract

  • OBJECTIVE: To investigate whether global and regional beta-amyloid (Abeta) burden as measured with 11C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD). METHODS: Ninety-two elderly healthy controls, 32 subjects with aMCI, and 35 patients with AD were imaged using 11C-PIB PET and MRI. Hippocampal volume was measured and PIB standardized uptake value ratio was extracted after partial volume correction within 41 regions of interest. Global, regional, and voxel-based correlations between PIB and hippocampal volume were computed for each group. RESULTS: In healthy control participants with elevated neocortex PIB retention, significant correlation was found between PIB retention in the inferior temporal region and hippocampal volume using both region-based and voxel-based approaches. No correlation was found in any other group. CONCLUSIONS: The strong correlation between hippocampal atrophy and beta-amyloid (Abeta) burden in the Pittsburgh compound B-positive healthy control group suggests that Abeta deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration.

authors

  • Bourgeat, P
  • Chetelat, G
  • Villemagne, VL
  • Fripp, J
  • Raniga, P
  • Pike, K
  • Acosta, O
  • Szoeke, C
  • Ourselin, S
  • Ames, D
  • Ellis, KA
  • Martins, RN
  • Masters, CL
  • Rowe, CC
  • Salvado, O

publication date

  • January 12, 2010

has subject area