Cardioprotective 3′,4′-dihydroxyflavonol attenuation of JNK and p38MAPK signalling involves CaMKII inhibition Academic Article uri icon

abstract

  • 3′,4′-Dihydroxyflavonol, a cardioprotective compound that prevents cardiac injury and cell death, targets Ca2+/camodulin-dependent protein kinase II to inhibit the activation of the stress-activated protein kinases, c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.

authors

  • Lim, Nicholas R
  • Thomas, Colleen J
  • Silva, Lokugan S
  • Yeap, Yvonne Y
  • Yap, Suwan
  • Bell, James R
  • Delbridge, Lea MD
  • Bogoyevitch, Marie A
  • Woodman, Owen L
  • Williams, Spencer J
  • May, Clive N
  • Ng, Dominic CH

publication date

  • December 1, 2013

has subject area