Genetic variation among lambs in peripheral IgE activity against the larval stages ofTeladorsagia circumcincta Academic Article uri icon

abstract

  • SUMMARYIgA and IgE activity againstTeladorsagia circumcinctawas investigated in a flock of Texel lambs following natural, mixed nematode infection among lambs. The distribution of IgA activity was similar to a gamma distribution whereas IgE activity was different. Box-Cox analysis demonstrated that X0·25was a suitable transformation to normalise IgE responses. The transformed IgE activity was under moderate to strong genetic control. Nine different allergens were identified by proteomic analysis. Tropomyosin was selected for further analysis. IgE activity against tropomyosin was moderately heritable and associated with decreased egg counts and with reduced body weight at the time of sampling.

authors

  • MURPHY, L
  • ECKERSALL, PD
  • BISHOP, SC
  • PETTIT, JJ
  • HUNTLEY, JF
  • BURCHMORE, R
  • STEAR, MJ

publication date

  • July 2010