Upexpression of BHLHE40 in gastric epithelial cells increases CXCL12 production through interaction with p-STAT3 in Helicobacter pylori-associated gastritis Academic Article uri icon

abstract

  • BHLHE40, a member of the basic helix-loop-helix transcription factor family, has been reported to play an important role in inflammatory diseases. However, the regulation and function of BHLHE40 in Helicobacter pylori (H pylori)-associated gastritis is unknown. We observed that gastric BHLHE40 was significantly elevated in patients and mice with H pylori infection. Then, we demonstrate that H pylori-infected GECs express BHLHE40 via cagA-ERK pathway. BHLHE40 translocates to cell nucleus, and then binds to cagA protein-activated p-STAT3 (Tyr705). The complex increases chemotactic factor CXCL12 expression (production). Release of CXCL12 from GECs fosters CD4+ T cell infiltration in the gastric mucosa. Our results identify the cagA-BHLHE40-CXCL12 axis that contributes to inflammatory response in gastric mucosa during H pylori infection.

authors

  • Teng, YS
  • Zhao, YL
  • Li, MS
  • Liu, YG
  • Cheng, P
  • Lv, YP
  • Mao, FY
  • Chen, Weisan
  • Yang, SM
  • Hao, CJ
  • Peng, LS
  • Zhang, JY
  • Zhang, WJ
  • Zou, QM
  • Zhuang, Y

publication date

  • 2020

has subject area