Reaction with acetic anhydride as a method for estimating the basicity of exocyclic amino groups in nitrogen heterocycles Academic Article uri icon

abstract

  • Relative rates for acetylation of various anilines and amino heterocycles with acetic anhydride in pyridine were determined by a competition method. From a Bronsted plot of reactivity against basicity for the anilines, and by considering the heterocycles as substituted anilines, pKa values for the amino group in a variety of heterocycles have been obtained.

publication date

  • 1984