Synthesis and Antibacterial Activity of Some 'Bisquinolones' Academic Article uri icon

abstract

  • Ten ' bisquinolones' were prepared by joining two molecules of norfloxacin, or 1,8-naphthyridine and benzo [c][1,8] naphthyridine derivatives, with various aliphatic linkers. These were tested against 17 bacteria strains but none showed more than slight activity (MIC ≥ 10 mg/l). However, a 'monoquinolone' derived from benzo [c][1,8] naphthyridine showed greater activity than norfloxacin against a strain of Acinetobacter.

authors

  • Coppel, RL
  • Deady, LW
  • Loria, PM
  • Olden, DC
  • Turnidge, JD

publication date

  • 1996