Association Between Lifestyle and Hypertriglyceridemic Waist Phenotype in the PREDIMED‐Plus Study Academic Article uri icon

abstract

  • OBJECTIVE:The hypertriglyceridemic waist (HTGW) phenotype is characterized by abdominal obesity and high levels of triglycerides. In a cross-sectional assessment of PREDIMED-Plus trial participants at baseline, HTGW phenotype prevalence was evaluated, associated risk factors were analyzed, and the lifestyle of individuals with metabolic syndrome and HTGW was examined. METHODS:A total of 6,874 individuals aged 55 to 75 with BMI ≥ 27 and < 40 kg/m2 were included and classified by presence (HTGW+ ) or absence (HTGW- ) of HTGW (waist circumference: men ≥ 102 cm, women ≥ 88 cm; fasting plasma triglycerides ≥ 150 mg/dL). Analytical parameters and lifestyle (energy intake and expenditure) were analyzed. RESULTS:A total of 38.2% of the sample met HTGW+ criteria. HTGW+ individuals tended to be younger, have a greater degree of obesity, be sedentary, and be tobacco users. They had higher peripheral glucose, total cholesterol, and low-density lipoprotein cholesterol levels; had lower high-density lipoprotein cholesterol levels; and had increased prevalence of type 2 diabetes mellitus. Mediterranean diet (MedDiet) adherence and physical activity were greater in HTGW- patients. Age, BMI, tobacco use, total energy expenditure, hypertension, type 2 diabetes mellitus, and MedDiet adherence were associated with HTGW+ . CONCLUSIONS:HTGW is a highly prevalent phenotype in this population associated with younger age, higher BMI, tobacco use, and decreased MedDiet adherence. HTGW- individuals were more physically active with greater total physical activity, and fewer had hypertension.

authors

  • Fernández‐García, José Carlos
  • Muñoz‐Garach, Araceli
  • Martinez-Gonzalez, Miguel
  • Salas‐Salvado, Jordi
  • Corella, Dolores
  • Hernáez, Álvaro
  • Romaguera, Dora
  • Vioque, Jesús
  • Alonso‐Gómez, Ángel M
  • Wärnberg, Julia
  • Martínez, J Alfredo
  • Serra‐Majem, Luís
  • Estruch, Ramón
  • Lapetra, José
  • Pintó, Xavier
  • Tur, Josep A
  • Garcia‐Rios, Antonio
  • García Molina, Laura
  • Gaforio, José Juan
  • Matía‐Martín, Pilar
  • Daimiel, Lidia
  • Martín Sánchez, Vicente
  • Vidal, Josep
  • Prieto, Lucia
  • Ros, Emilio
  • Goñi, Nuria
  • Babio, Nancy
  • Ortega‐Azorin, Carolina
  • Castañer, Olga
  • Konieczna, Jadwiga
  • Notario Barandiaran, Leyre
  • Vaquero‐Luna, Jessica
  • Benavente‐Marín, Juan Carlos
  • Zulet, M Angeles
  • Sanchez‐Villegas, Almudena
  • Sacanella, Emilio
  • Gómez Huelgas, Ricardo
  • Miró‐Moriano, Leticia
  • Gimenez‐Gracia, Mariano
  • Julibert, Alicia
  • Razquin, Cristina
  • Basora, Josep
  • Portolés, Olga
  • Goday, Albert
  • Galmés‐Panadés, Aina M
  • López‐García, Carmen M
  • Moreno‐Rodriguez, Anai
  • Toledo, Estefanía
  • Díaz‐López, Andrés
  • Fitó, Montserrat
  • Tinahones, Francisco J
  • Bernal‐López, M Rosa

publication date

  • 2020