MERP1: a mammalian ependymin-related protein gene differentially expressed in hematopoietic cells Academic Article uri icon

abstract

  • We have utilized differential display polymerase chain reaction to investigate the gene expression of hematopoietic progenitor cells from adult bone marrow and umbilical cord blood. A differentially expressed gene was identified in CD34+ hematopoietic progenitor cells, with low expression in CD34- cells. We have obtained the full coding sequence of this gene which we designated human mammalian ependymin-related protein 1 (MERP1). Expression of MERP1 was found in a variety of normal human tissues, and is 4- and 10-fold higher in adult bone marrow and umbilical cord blood CD34+ cells, respectively, compared to CD34- cells. Additionally, MERP1 expression in a hematopoietic stem cell enriched population was down-regulated with proliferation and differentiation. Conceptual translation of the MERP1 open reading frame reveals significant homology to two families of glycoprotein calcium-dependant cell adhesion molecules: ependymins and protocadherins.

authors

  • Gregorio-King, Claudia C
  • McLeod, Janet L
  • Collier, Fiona McL
  • Collier, Gregory R
  • Bolton, Karyn A
  • Van Der Meer, Gavin J
  • Apostolopoulos, Jim
  • Kirkland, Mark A

publication date

  • March 2002

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