Global and regional burden of cancer in 2016 arising from occupational exposure to selected carcinogens: a systematic analysis for the Global Burden of Disease Study 2016 Academic Article uri icon

abstract

  • ObjectivesThis study provides a detailed analysis of the global and regional burden of cancer due to occupational carcinogens from the Global Burden of Disease 2016 study.MethodsThe burden of cancer due to 14 International Agency for Research on Cancer Group 1 occupational carcinogens was estimated using the population attributable fraction, based on past population exposure prevalence and relative risks from the literature. The results were used to calculate attributable deaths and disability-adjusted life years (DALYs).ResultsThere were an estimated 349 000 (95% Uncertainty Interval 269 000 to 427 000) deaths and 7.2 (5.8 to 8.6) million DALYs in 2016 due to exposure to the included occupational carcinogens—3.9% (3.2% to 4.6%) of all cancer deaths and 3.4% (2.7% to 4.0%) of all cancer DALYs; 79% of deaths were of males and 88% were of people aged 55 –79 years. Lung cancer accounted for 86% of the deaths, mesothelioma for 7.9% and laryngeal cancer for 2.1%. Asbestos was responsible for the largest number of deaths due to occupational carcinogens (63%); other important risk factors were secondhand smoke (14%), silica (14%) and diesel engine exhaust (5%). The highest mortality rates were in high-income regions, largely due to asbestos-related cancers, whereas in other regions cancer deaths from secondhand smoke, silica and diesel engine exhaust were more prominent. From 1990 to 2016, there was a decrease in the rate for deaths (−10%) and DALYs (−15%) due to exposure to occupational carcinogens.ConclusionsWork-related carcinogens are responsible for considerable disease burden worldwide. The results provide guidance for prevention and control initiatives.

authors

  • Driscoll, Tim
  • Rushton, Lesley
  • Steenland, Kyle
  • Hutchings, Sally
  • Straif, Kurt
  • Abate, Degu
  • Abdel-Rahman, Omar
  • Acharya, Dilaram
  • Afarideh, Mohsen
  • Alahdab, Fares
  • Al-Aly, Ziyad
  • Anjomshoa, Mina
  • Aremu, Olatunde
  • Artaman, Al
  • Ataro, Zerihun
  • Ayala Quintanilla, Beatriz Paulina
  • Badawi, Alaa
  • Behzadifar, Masoud
  • Behzadifar, Meysam
  • Beuran, Mircea
  • Bhattacharyya, Krittika
  • Bijani, Ali
  • Bjorge, Tone
  • Butt, Zahid A
  • Carrero, Juan J
  • Carvalho, Felix
  • Castaneda-Orjuela, Carlos A
  • Cerin, Ester
  • Chaturvedi, Pankaj
  • Chimed-Ochir, Odgerel
  • Crider, Raquel
  • Crowe, Christopher Stephen
  • Dandona, Lalit
  • Dandona, Rakhi
  • Dang, Anh Kim
  • Daryani, Ahmad
  • Desalegn, Beruk Berhanu
  • Dharmaratne, Samath Dhamminda
  • Djalalinia, Shirin
  • Effiong, Andem
  • El-Khatib, Ziad
  • Esteghamati, Alireza
  • Fareed, Mohammad
  • Fernandes, Eduarda
  • Filip, Irina
  • Fischer, Florian
  • Fukumoto, Takeshi
  • Gallus, Silvano
  • Gebremichael, Teklu Gebrehiwo
  • Gezae, Kebede Embaye
  • Grada, Ayman
  • Guimaraes, Andre Luiz Sena
  • Gupta, Rahul
  • Hafezi-Nejad, Nima
  • Haj-Mirzaian, Arvin
  • Haj-Mirzaian, Arya
  • Hamadeh, Randah R
  • Hamidi, Samer
  • Hassankhani, Hadi
  • Hay, Simon I
  • Hegazy, Mohamed I
  • Henok, Andualem
  • Hoang, Chi Linh
  • Hole, Michael K
  • Hosgood, H Dean
  • Hosseini, Mostafa
  • Hostiuc, Mihaela
  • Hostiuc, Sorin
  • Irvani, Seyed Sina Naghibi
  • Islam, Sheikh Mohammed Shariful
  • Jakovljevic, Mihajlo
  • Jha, Ravi Prakash
  • Jurisson, Mikk
  • Kahsay, Amaha
  • Karim, Narges
  • Kasaeian, Amir
  • Kassa, Zemenu Yohannes
  • Khader, Yousef Saleh
  • Khafaie, Morteza Abdullatif
  • Khan, Ejaz Ahmad
  • Khosravi, Mohammad Hossein
  • Khubchandani, Jagdish
  • Kiadaliri, Aliasghar A
  • Kim, Yun Jin
  • Kogevinas, Manolis
  • Koh, David
  • Kosen, Soewarta
  • Koyanagi, Ai
  • Kumar, G Anil
  • Lad, Deepesh P
  • Lal, Dharmesh Kumar
  • Lami, Faris Hasan
  • Latifi, Arman
  • Leigh, James
  • Linn, Shai
  • Majdan, Marek
  • Malekzadeh, Reza
  • Malta, Deborah Carvalho
  • Mansournia, Mohammad Ali
  • Massenburg, Benjamin Ballard
  • Melese, Addisu
  • Melku, Mulugeta
  • Memish, Ziad A
  • Mendoza, Walter
  • Mengistu, Getnet
  • Meretoja, Tuomo J
  • Mestrovic, Tomislav
  • Miazgowski, Bartosz
  • Miazgowski, Tomasz
  • Mirrakhimov, Erkin M
  • Moazen, Babak
  • Mohammed, Shafiu
  • Mohebi, Farnam
  • Mokdad, Ali H
  • Moodley, Yoshan
  • Moosazadeh, Mahmood
  • Moradi, Ghobad
  • Morawska, Lidia
  • Morrison, Shane Douglas
  • Mousavi, Seyyed Meysam
  • Mustafa, Ghulam
  • Negoi, Ionut
  • Negoi, Ruxandra Irina
  • Nguyen, Cuong Tat
  • Nguyen, Trang Huyen
  • Ningrum, Dina Nur Anggraini
  • Nixon, Molly R
  • Ofori-Asenso, Richard
  • Ogbo, Felix Akpojene
  • Olagunju, Andrew T
  • Olusanya, Bolajoko Olubukunola
  • Ortega-Altamirano, Doris DV
  • Mahesh, PA
  • Park, Eun-Kee
  • Pereira, David M
  • Prakash, Swayam
  • Qorbani, Mostafa
  • Radfar, Amir
  • Rafay, Anwar
  • Rafiei, Alireza
  • Rahim, Fakher
  • Rahimi-Movaghar, Vafa
  • Rajati, Fatemeh
  • Reiner, Robert C
  • Renzaho, Andre MN
  • Rezaei, Satar
  • Roever, Leonardo
  • Saadat, Mohammad
  • Saddik, Basema
  • Safari, Saeed
  • Safiri, Saeid
  • Sahebkar, Amirhossein
  • Sahraian, Mohammad Ali
  • Salimzadeh, Hamideh
  • Samy, Abdallah M
  • Sanabria, Juan
  • Sarmiento-Suarez, Rodrigo
  • Sathian, Brijesh
  • Schwebel, David C
  • Sepanlou, Sadaf G
  • Serdar, Berrin
  • Shaikh, Masood Ali
  • Sharma, Rajesh
  • She, Jun
  • Shigematsu, Mika
  • Shirkoohi, Reza
  • Si, Si
  • Sinha, Dhirendra Narain
  • Soofi, Moslem
  • Stanaway, Jeffrey D
  • Stokes, Mark A
  • Tabares-Seisdedos, Rafael
  • Tabuchi, Takahiro
  • Takahashi, Ken
  • Tefera, Yonatal Mesfin
  • Temsah, Mohamad-Hani
  • Tovani-Palone, Marcos Roberto
  • Tran, Bach Xuan
  • Tran, Khanh Bao
  • Ullah, Irfan
  • Valdez, Pascual R
  • Vasankari, Tommi Juhani
  • Violante, Francesco S
  • Vlassov, Vasily
  • Vu, Giang Thu
  • Waheed, Yasir
  • Wang, Yuan-Pang
  • Yeshaneh, Alex
  • Yirsaw, Biruck Desalegn
  • Yisma, Engida
  • Yonemoto, Naohiro
  • Yousefifard, Mahmoud
  • Yu, Chuanhua
  • Zadnik, Vesna
  • Zamani, Mohammad
  • Zandian, Hamed
  • Zodpey, Sanjay
  • Lim, Stephen S

publication date

  • 2020

has subject area