Imaging of neuroinflammation in adult Niemann-Pick type C disease: a cross-sectional study Academic Article uri icon

abstract

  • ObjectiveTo test the hypothesis that neuroinflammation is a key process in adult Niemann-Pick type C (NPC) disease, we undertook PET scanning utilizing a ligand binding activated microglia on 9 patients and 9 age- and sex-matched controls.MethodWe scanned all participants with the PET radioligand 11C-(R)-PK-11195 and undertook structural MRI to measure gray matter volume and white matter fractional anisotropy (FA).ResultsWe found increased binding of 11C-(R)-PK-11195 in total white matter compared to controls (p < 0.01), but not in gray matter regions, and this did not correlate with illness severity or duration. Gray matter was reduced in the thalamus (p < 0.0001) in patients, who also showed widespread reductions in FA across the brain compared to controls (p < 0.001). A significant correlation between 11C-(R)-PK11195 binding and FA was shown (p = 0.002), driven by the NPC patient group.ConclusionsOur findings suggest that neuroinflammation—particularly in white matter—may underpin some structural and degenerative changes in patients with NPC.

authors

  • Walterfang, Mark
  • Di Biase, Maria A
  • Cropley, Vanessa L
  • Scott, Andrew M
  • O'Keefe, Graeme
  • Velakoulis, Dennis
  • Pathmaraj, Kunthi
  • Ackerman, Uwe
  • Pantelis, Christos

publication date

  • 2020