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Professor Robert Brownlee Emeritus Professor, Chemistry
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Professor Robert Brownlee Emeritus Professor, Chemistry
Prof. Brownlee is currently investigating a number of research problems, including Biological Chemistry Multinuclear NMR. NMR structure of polypeptides and proteins computer aided drug design. Design and synthesis of DNA binding compounds; The Structure of small and unusual cyclic peptides; Protein/DNA Interactions, and Drug Design, and Application of NMR to Industrial and Analytical Analysis.
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Research Areas
- Analysis of chemicals (Expertise)
- Chemistry and chemicals (Expertise)
- Computational Chemistry (Expertise)
- Magnetic resonance spectrum (Expertise)
- Molecular graphics (Expertise)
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Publications
selected publications
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academic article
- Maharani RBrownlee RTCHughes ABAbbott BM. A total synthesis of a highly N-methylated cyclodepsipeptide [2S,3S-Hmp]-aureobasidin L using solid-phase methods. Tetrahedron. 70:2351-2358. 2014
- Ankers EAEvison BJPhillips DRBrownlee RTCCutts SM. Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide. Bioorganic and Medicinal Chemistry Letters. 24:5710-5715. 2014
- Oehme DPBrownlee RTCWilson DJD. Can cyclic HIV protease inhibitors bind in a non-preferred form? An ab initio, DFT and MM-PB(GB)SA study. Journal of Molecular Modeling. 19:1125-1142. 2013
- Oehme DPBrownlee RTCWilson DJD. Effect of atomic charge, solvation, entropy, and ligand protonation state on MM-PB(GB)SA binding energies of HIV protease. Journal of Computational Chemistry. 33:2566-2580. 2012
- Oehme DPWilson DJDBrownlee RTC. Effect of Structural Stress on the Flexibility and Adaptability of HIV-1 Protease. Journal of Chemical Information and Modeling. 51:1064-1073. 2011
- Kimura KSpencer DBilardi RSwift LBox ABrownlee RCutts SPhillips D. Barminomycin, a Model for the Development of New Anthracyclines. Anti-Cancer Agents in Medicinal Chemistry. 10:70-77. 2010
- Ng CAOehme DPKato YTanokura MBrownlee RTC. Binding of an RNA pol II Ligand to the WW Domain of Pin1 Using Molecular Dynamics Docking Simulations. Journal of Chemical Theory and Computation. 5:2886-2897. 2009
- Hughes AVan Nguyen TBrownlee R. A Novel Synthesis of N-But-3-enyl-α- and β-Amino Acids. Synthesis: journal of synthetic organic chemistry. 2009:1991-1998. 2009
- Ng CAKato YTanokura MBrownlee RTC. Structural characterisation of PinA WW domain and a comparison with other Group IV WW domains, Pin1 and Ess1. BBA: Proteins and Proteomics. 1784:1208-1214. 2008
- Cendron ACWines BDBrownlee RTCRamsland PAPietersz GAHogarth PM. An FcγRIIa-binding peptide that mimics the interaction between FcγRIIa and IgG. Molecular Immunology. 45:307-319. 2008
- Aurelio LBrownlee RTCHughes AB. Solution-Phase Peptide Synthesis; Synthesis of 'North-Western' and 'South-Eastern' Fragments of the Antifungal Cyclodepsipeptide Petriellin A. Australian Journal of Chemistry: an international journal for chemical science. 61:615-615. 2008
- Schmid FSeparovic FMcDougall BMStone BABrownlee RTCSeviour RJ. Characterisation of the extracellular polysaccharides produced by isolates of the fungus Acremonium. Carbohydrate Research. 342:2481-2483. 2007
- Kato YNg CABrownlee RTCTanokura M. PinA from Aspergillus nidulans binds to pS/pT-P motifs using the same Loop I and XP groove as mammalian Pin1. BBA: Proteins and Proteomics. 1774:1208-1212. 2007
- Ng CAZhao WDang JBergdahl MSeparovic FBrownlee RTCMetzger RP. The conformation of acetylated virginiamycin M1 and virginiamycin M1 in explicit solvents. BBA: Proteins and Proteomics. 1774:610-618. 2007
- Dinev ZWardak AZBrownlee RTCWilliams SJ. A convenient gram-scale synthesis of uridine diphospho(13C6)glucose. Carbohydrate Research. 341:1743-1747. 2006
- Schmid FStone BABrownlee RTCMcDougall BMSeviour RJ. Structure and assembly of epiglucan, the extracellular (1→3;1→6)-β-glucan produced by the fungus Epicoccum nigrum strain F19. Carbohydrate Research. 341:365-373. 2006
- Aurelio LBrownlee RTCDang JHughes ABPolya GM. Determination of the Complete Absolute Configuration of Petriellin A. Australian Journal of Chemistry: an international journal for chemical science. 59:407-407. 2006
- Dang JMetzger RPBrownlee RTCNg CABergdahl MSeparovic F. The conformational flexibility of the antibiotic virginiamycin M1. European Biophysics Journal. 34:383-388. 2005
- Aurelio LBrownlee RTCHughes AB. Synthetic Preparation ofN-Methyl-α-amino Acids. Chemical Reviews. 104:5823-5846. 2004
- Brownlee RTDang JBergdahl BMSeparovic FT. C. Brownlee RP. Metzger R. Difference in Conformation of Virginiamycin M1 in Chloroform and Bound Form in the 50S Ribosome or Streptogramin Acetyltransferase. Australian Journal of Chemistry: an international journal for chemical science. 57:415-415. 2004
- Dang JBergdahl MSeparovic FBrownlee RTCMetzger RP. Solvent affects the conformation of virginiamycin M1(pristinamycin IIA, streptogramin A). Organic and Biomolecular Chemistry. 2:2919-2919. 2004
- Aurelio LBox JSBrownlee RTCHughes ABSleebs MM. An Efficient Synthesis ofN-Methyl Amino Acids by Way of Intermediate 5-Oxazolidinones. Journal of Organic Chemistry. 68:2652-2667. 2003
- Aurelio LBrownlee RTCHughes AB. A Novel Synthesis ofN-Methyl Asparagine, Arginine, Histidine, and Tryptophan. Organic Letters. 4:3767-3769. 2002
- Schmid FStone BAMcDougall BMBacic AMartin KLBrownlee RTCChai ESeviour RJ. Structure of epiglucan, a highly side-chain/branched (1→3;1→6)-β-glucan from the micro fungus Epicoccum nigrum Ehrenb. ex Schlecht. Carbohydrate Research. 331:163-171. 2001
- Boskovic CSadek MBrownlee RTCBond AMWedd AG. Electrosynthesis and solution structure of six-electron reduced forms of metatungstate, [H2W12O40]6− †. Dalton Transactions: an international journal of inorganic chemistry. 187-196. 2001
- Schmid FStone BMcDougall BBacic AMartin KBrownlee RChai ESeviour R. Structure of epiglucan, a highly branched (1-3)-B-glucan from the fungus Epicoccum purpurascens Ehrenb.ex Schecht. Carbohydrate Research. 331:163-171. 2001
- Aurelio LBrownlee RTCHughes ABSleebs BE. The Facile Production of N-Methyl Amino Acids via Oxazolidinones. Australian Journal of Chemistry: an international journal for chemical science. 53:425-425. 2000
- Coo LDSadek MBrownlee RTCCardwell TJCattrall RWKolev SD. Determination of the diffusion coefficient of 1-(2′-pyridylazo)-2-naphthol in ethanol–water solutions using flow injection and nuclear magnetic resonance techniques. Analytica Chimica Acta. 386:137-144. 1999
- Boskovic CWedd AGSadek MBrownlee RTCBond AM. Lifting the lid on metatungstate. 1H and 183W NMR study of the six electron reduced anion [(H)2{WIV3(OH2)3}WVI9O34(OH)3]3−. Chemical Communications. 533-534. 1999
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Way DMCooper JBSadek MVu TMahon PJBond AMBrownlee RTCWedd AG. Systematic Electrochemical Synthesis of Reduced Forms of the α[S
2 -Mo18 O62 ]4- Anion1. Inorganic Chemistry: including bioinorganic chemistry. 36:4227-4233. 1997 - Way DMCooper JBSadek MVu TMahon PJBond AMBrownlee RTCWedd AG. Systematic Electrochemical Synthesis of Reduced Forms of the α-[S2Mo18O62]4-Anion1. Inorganic Chemistry: including bioinorganic chemistry. 36:4227-4233. 1997
- Chen LSadek MStone BABrownlee RTCFincher GBHøj PB. Stereochemical course of glucan hydrolysis by barley (1 → 3)- and (1 → 3,1 → 4)-β-glucanases. BBA: Proteins and Proteomics. 1253:112-116. 1995
- Chiu FCKBrownlee RTCMitchell KPhillips DR. 9-Aminoacridine-EDTA conjugates as hydroxy radical footprinting reagents with no intrinsic cutting specificity. Bioorganic and Medicinal Chemistry Letters. 5:1689-1694. 1995
- Scrofani SDBBrownlee RTCSadek MWedd AG. Sequence-specific 1H, 13C, and 15N NMR assignments for oxidized ferredoxin from Clostridium pasteurianum. Inorganic Chemistry: including bioinorganic chemistry. 34:3942-3952. 1995
- Sadek MScrofani SDBBrownlee RTCWedd AG. Nitrogen-15 detection of broad amide protons in paramagnetic proteins. Journal of the Chemical Society - Series Chemical Communications. 105-105. 1995
- Scrofani SDBBrereton PSHamer AMLavery MJMcDowall SGVincent GABrownlee RTCHoogenraad NJSadek MWedd AG. Comparison of Native and Mutant Proteins Provides a Sequence-Specific Assignment of the Cysteinyl Ligand Proton NMR Resonances in the 2[Fe4S4] Ferredoxin from Clostridium pasteurianum. Biochemistry. 33:14486-14495. 1994
- Chiu FCKBrownlee RTCMitchell KPhillips DR. The unique DNA cutting sequence specificity of a 4-(N,N-dimethyl-2-aminoethyl)amino-1,10-phenanthroline and its 9-aminoacridine conjugate. Bioorganic and Medicinal Chemistry Letters. 4:2721-2726. 1994
- Bambino FBrownlee RTCChiu FCK. Synthesis of a symmetrically branched template for parallel α-helix dimers. Tetrahedron Letters. 35:4619-4622. 1994
- Bambino FBrownlee RTCChiu FCK. Synthesis of peptides containing α, α dialkyl amino acids. Tetrahedron Letters. 35:4615-4618. 1994
- Chiu FCKBrownlee RTCPhillips DR. Synthesis of 4-amino substituted and 4-unsubstituted 1,10-phenanthroline-3-carboxylic acid derivatives as potential DNA cleavage reagents. Tetrahedron. 50:889-894. 1994
- Young CGKocaba TOSadek MBrownlee RTCTiekink ERT. Tris(N,N-dialkyldithiocarbamato-S,S')thiotungsten(VI) Complexes and the X-Ray Crystal Structure of [WS(S2CNEt2)3]BF4. Australian Journal of Chemistry: an international journal for chemical science. 47:2075-2075. 1994
- Sadek MBrownlee RTCScrofani SDBWedd AG. TOCSY Assignment of Broad Resonances in Paramagnetic Proteins. Journal of Magnetic Resonance - Series B. 101:309-314. 1993
- CHIU FCKBROWNLEE RTCPHILLIPS DR. CUPRIC ION CHELATION ASSISTED SYNTHESIS OF N(ALPHA)-PROTECTED N(OMEGA)-ACRIDIN-9-YL ALPHA,OMEGA-DIAMINO CARBOXYLIC-ACIDS. Australian Journal of Chemistry: an international journal for chemical science. 46:1207-1212. 1993
- Chiu FCKBrownlee RTCPhillips DR. Cupric Ion Chelation Assisted Synthesis of N(α)-Protected N(ω)-Acridin-9-yl α,ω-Diamino Carboxylic Acids. Australian Journal of Chemistry: an international journal for chemical science. 46:1207-1207. 1993
- Kony MBrownlee RTCWedd AG. Complexes of tetrathiomolybdate and -tungstate with copper(I) and silver(I): sulfur-33 NMR properties. Inorganic Chemistry: including bioinorganic chemistry. 31:2281-2282. 1992
- Harris PJSadek MBrownlee RTCBlakeney ABWebster JStone BA. The detection and quantification of apiose by capillary gas chromatography of its alditol acetates. Carbohydrate Research. 227:365-370. 1992
- Phillips DRBrownlee RTCReiss JAScourides PA. Bis-daunomycin hydrazones: Interactions with DNA. Investigational New Drugs. 10:79-88. 1992
- Woodburn KWPhillips DRBellinger GCASadek MBrownlee RTCReiss JA. Synthesis and phototoxicity of a series of haematoporphyrin analogues. Bioorganic and Medicinal Chemistry Letters. 2:343-344. 1992
- Bambino FBrownlee RTCChiu FCK. Facile synthesis of protected dipeptide acids containing C-terminal α,α-dialkyl amino acids.. Tetrahedron Letters. 32:3407-3408. 1991
- Drew JLiodakis AChan RDu HSadek MBrownlee RSawyer WH. Preparation of lipid emulsions by pressure extrusion. Biochemistry International. 22:983-992. 1990
- Tonkin KBoston RBrownlee RCPhillips D. Fluorinated anthracyclines: interactions with DNA. Investigational New Drugs. 8:355-363. 1990
- Tonkin KBrownlee RCZunino FPhillips D. Fluorinated anthracyclines: Synthesis and biological activity. Investigational New Drugs. 8:1-6. 1990
- Phillips DRBaguley BCBrownlee RTCCacioli PChandler CJKyratzis IReiss JAScourides PA. The synthesis, stability and biological activity of bis-intercalating bis-daunomycin hydrazones. Drug Design and Delivery. 5:203-219. 1990
- Craik DJBrownlee RTC. Graphics-aided NMR. Annual Reports on NMR Spectroscopy. 21:1-50. 1989
- Chandler CJBrownlee RTCHook RJPhillips DRReiss JAEdgar JA. Fast atom bombardment mass spectrometry of some anthracycline and bisanthracycline derivatives. Biological Mass Spectrometry. 17:21-25. 1988
- Gale DJCraik DJBrownlee RTC. Variable-temperature NMR studies of thyroid hormone conformations. Magnetic Resonance in Chemistry. 26:275-280. 1988
- Brownlee RTCShehan BPWedd AG. Applications of 95Mo N.M.R. Spectroscopy. XVIII. Relaxation Times, Quadrupole Coupling Constants and Partial Field Gradients in [Mo(CO)5L] Complexes. Australian Journal of Chemistry: an international journal for chemical science. 41:1457-1457. 1988
- Skorobogaty ABrownlee RTCChandler CJKyratzis IPhillips DRReiss JATrist H. The DNA-association and biological activity of a new bis(14-thiadaunomycin). Oncology Research. 3:41-56. 1988
- Brownlee RTCShehan BPWedd AG. Applications of molybdenum-95 NMR spectroscopy. 17. Molybdenum-95 and nitrogen-14 relaxation time measurements confirming that octacyanomolybdate(4-) is dodecahedral in aqueous solution. Inorganic Chemistry: including bioinorganic chemistry. 26:2022-2024. 1987
- Brownlee RTCMcFadyen WDO'Connor MJRook TJRoos IAGWakelin LPG. NMR study of substituent effects in platinum(II) intercalating agents. Magnetic Resonance in Chemistry. 25:492-496. 1987
- Bromilow JBrownlee RTCCraik DJSadek M. Non-additive carbon-13 NMR substituent chemical shifts. II—1,3-disubstituted benzenes. Magnetic Resonance in Chemistry. 24:862-871. 1986
- Brownlee RTCSadek M. Natural abundance15N chemical shifts in substituted benzamides and thiobenzamides. Magnetic Resonance in Chemistry. 24:821-826. 1986
- Brownlee RTCShehan BP. NMR relaxation times and quadrupole coupling constants in [M(CO)6] (M Cr, Mo, W) and [V(CO)6]−. Transition-metal quadrupole moments. 17O relaxation times and bonding. Journal of Magnetic Resonance (1969). 66:503-510. 1986
- Chandler CJPhillips DRBrownlee RTCReiss JA. Ammonium bicarbonate mediated high-performance liquid chromatography resolution of bis-anthracyclines. Journal of Chromatography A. 358:179-186. 1986
- Brownlee RTCOconnor MJShehan BPWedd AG. Applications of 95Mo N.M.R-Spectroscopy. XVI. Structure and Bonding in [Mo(Co)3(η6-Arene)] Complexes From 95Mo,13C and 17O Relaxation-Times. Australian Journal of Chemistry: an international journal for chemical science. 39:931-931. 1986
- Brownlee RTCCacioli PChandler CJPhillips DRScourides PAReiss JA. The synthesis and characterization of a series of bis-intercalating bis-anthracyclines. Journal of the Chemical Society - Series Chemical Communications. 659-659. 1986
- Minelli MEnemark JHBrownlee RTCO’connor MJWedd AG. The nuclear magnetic resonance properties of chromium, molybdenum and tungsten compounds. Coordination Chemistry Reviews. 68:169-278. 1985
- Brownlee RTCO'Connor MJShehan BPWedd AG. Applications of 95Mo NMR spectroscopy. XV. 95Mo NMR parameters for [Mo(CO)6−n (pyridine)n] (n = 1−3) complexes. A reassignment of the fac-[Mo(CO)3(pyridine)3] resonance. Journal of Magnetic Resonance (1969). 64:142-144. 1985
- Shehan BPKony MBrownlee RTCO'Connor MJWedd AG. Applications of molybdenum-95 NMR spectroscopy. 14. Construction of a transverse probe for the detection of broad 95Mo resonances in solution. Studies on Binuclear Mo(II) compounds. Journal of Magnetic Resonance (1969). 63:343-353. 1985
- Brownlee RTCO'Connor MJShehan BPWedd AG. Applications of 95Mo NMR spectroscopy. XIII. Relaxation times of molybdenum compounds. Journal of Magnetic Resonance (1969). 61:516-525. 1985
- Brownlee RTCO'Connor MJShehan BPWedd AG. Applications of 95Mo NMR Spectroscopy. X1. 95Mo 97Mo, and 17O relaxation times, quadrupole coupling constants, and the molybdenum relaxation mechanism in Mo(CO)6. Journal of Magnetic Resonance (1969). 61:22-27. 1985
- Gheller SFHambley TWRodgers JRBrownlee RTCO'Connor MJSnow MRWedd AG. Synthesis and characterization of complexes of thiomolybdates and thiotungstates with copper(I) and silver(I) cyanides, including molybdenum-95 and tungsten-183 NMR properties and the crystal and molecular structures of (n-Pr4N)2[(CN)CuS2MoS2], (n-Pr4N)2[(CN)AgS2WS2], and (Ph4As)2[(CN)CuS2MoS2Cu(CN)].H2O. Inorganic Chemistry: including bioinorganic chemistry. 23:2519-2528. 1984
- Scourides PABrownlee RTCPhillips DRReiss JA. Application of analytical and semi-preparative high-performance liquid chromatography to anthracyclines and bis-anthracycline derivatives. Journal of Chromatography A. 288:127-136. 1984
- Gheller SFSidney MMasters AFBrownlee RTCO'Conner MJWedd AG. Applications of molybdenum-95 N.M.R. spectroscopy. X. Polyoxomolybdates. Australian Journal of Chemistry: an international journal for chemical science. 37:1825-1825. 1984
- Brownlee RTCSadek MCraik DJ. Ab initio MO calculations and17O NMR at natural abundance ofpara-substituted acetophenones. Magnetic Resonance in Chemistry. 21:616-620. 1983
- Brownlee RTCHall JGReiss JA. An application of the INEPT pulse sequence to the NMR assignment of halogenated marine natural products. Magnetic Resonance in Chemistry. 21:544-547. 1983
- Craik DJLevy GCBrownlee RTC. Substituent effects on nitrogen-15 and oxygen-17 chemical shifts in nitrobenzenes: correlations with electron densities. Journal of Organic Chemistry. 48:1601-1606. 1983
- Gheller SFHambley TWBrownlee RTCO'Connor MJSnow MRWedd AG. Applications of molybdenum-95 NMR spectroscopy. 7. Studies of metal-metal bonded systems including aqueous molybdenum(IV) and molybdenum(V). Crystal and molecular structure of Na2[Mo3O4((O2CCH2)2NCH3)3].7H2O. Journal of the American Chemical Society. 105:1527-1532. 1983
- Masters AFBosbard GEGeorge TABrownlee RTCO'Connor MJWedd AG. Applications of molybdenum-95 NMR. 8. Molybdenum(0) carbonyl derivatives of phosphines, phosphites and related ligands. Inorganic Chemistry: including bioinorganic chemistry. 22:908-911. 1983
- Brownlee RTCCraik DJ. Relationship between electron densities and chemical shifts. 3. para-Substituted benzoyl cations. Journal of the American Chemical Society. 105:872-875. 1983
- Andrews PRBrownlee RTCMackay MFPoulton DBSadek MWinkler DA. Conformational analysis of picrotoxinin by N.M.R., X-ray crystallography, and molecular orbital and classical potential-energy calculations. Australian Journal of Chemistry: an international journal for chemical science. 36:2219-2219. 1983
- SCHIBECI AHENRY RJSTONE BABROWNLEE RTC. P-31 NMR MEASUREMENT OF CYTOPLASMIC AND VACUOLAR PH IN ENDOSPERM CELLS OF RYEGRASS (LOLIUM-MULTIFLORUM) GROWN IN SUSPENSION-CULTURE. Biochemistry International. 6:837-844. 1983
- Brownlee RTCMasters AFO'Connor MJWedd AGKimlin HACotton JD. Applications of95Mo NMR. 5—substituent effects in the95Mo and13C NMR spectra of benzyltricarbonyl(η5-cyclopentadienyl)molybdenum(II) derivatives. Magnetic Resonance in Chemistry. 20:73-77. 1982
- Craik DJBrownlee RTCSadek M. Transmission of substituent effects via molecular lines of force: defense of the DSP method and an illustration of its use in explaining .pi. polarization. Journal of Organic Chemistry. 47:657-661. 1982
- Gheller SFHambley TWTraill PRBrownlee RTCO'Conner MJSnow MRWedd AG. Applications of molybdenum-95 N.M.R. spectroscopy. VI. 95Mo and 13C N.M.R. of certain cis-dioxomolybdenum(VI) compounds and related species. The crystal and molecular structure of Bis(N,N-diethylhydroxylamido(l -)-O,N)- disulfidomolybdenum(VI) hemibenzene. Australian Journal of Chemistry: an international journal for chemical science. 35:2183-2183. 1982
- Brownlee RTCMasters AFO'Connor MJWedd AGKimlin HACotton JDSadek M. Chemical Shifts of Quadrupole Nuclei. Applications of Mo-95 and O-17 NMR in Physical Organic Chemistry. Bulletin des Societes Chimiques Belges. 91:497-497. 1982
- Brownlee RTCCraik DJ. A theoretical investigation of the π-polarization mechanism. The importance of localized and extended polarization. Journal of the Chemical Society, Perkin Transactions 2. 760-764. 1981
- Masters AFBrownlee RTCO'Connor MJWedd AG. Applications of molybdenum-95 nuclear magnetic resonance spectroscopy. 3. Arenemolybdenum tricarbonyl derivatives. Inorganic Chemistry: including bioinorganic chemistry. 20:4183-4186. 1981
- Brownlee RTCCraik DJ. The relationship between19F and13C substituent chemical shifts and electron densities. 2—p-phenylacetyl fluorides. Magnetic Resonance in Chemistry. 15:248-256. 1981
- Bromilow JBrownlee RTCCraik DJFiske PRRowe JESadek M. Carbon-13 substituent chemical shifts in the side-chain carbons of aromatic systems: the importance of π-polarization in determining chemical shifts. Journal of the Chemical Society, Perkin Transactions 2. 753-759. 1981
- Gheller SFGazzana PAMasters AFBrownlee RTCO'Connor MJWedd AGRodgers JRSnow MR. Molybdenum-95 NMR of molybdenumsulfur and selenium species, structural charaterisation of the [(CN)CuS2MoS2]2− anion. Inorganica Chimica Acta. 54:L131-L132. 1981
- Brownlee RTCSadek M. Nonadditive carbon-13 nuclear magnetic resonance substituent shifts in 1,4-disubstituted benzenes. Application of the DSP-NLR equation to the OCOCH3, CONH2 and CSNH2 series. Australian Journal of Chemistry: an international journal for chemical science. 34:1593-1593. 1981
- Masters AFGheller SFBrownlee RTCO'Connor MJWedd AG. Interconversion of polyoxometallates. Inorganic Chemistry: including bioinorganic chemistry. 19:3866-3868. 1980
- Brownlee RTCCraik DJ. The relationship between19F substituent chemical shifts and electron densities:meta- andpara-substituted benzoyl fluorides. Magnetic Resonance in Chemistry. 14:186-191. 1980
- Masters AFBrownlee RTCO'Connor MJWedd AGCotton JD. Molybdenum-95 nuclear magnetic resonance. Applications to substituted carbonyls. Journal of Organometallic Chemistry. 195:C17-C20. 1980
- Bromilow JBrownlee RTCCraik DJSadek MTaft RW. Nonadditive carbon-13 nuclear magnetic resonance substituent shifts in 1,4-disubstituted benzenes. Nonlinear resonance and shift-charge ratio effects. Journal of Organic Chemistry. 45:2429-2438. 1980
- Brownlee RTCCraik DJ. 19F N.M.R. chemical shifts in substituted benzotrifluorides and benzal fluorides. Australian Journal of Chemistry: an international journal for chemical science. 33:2555-2555. 1980
- Katritzky ARBrownlee RTCMusumarra G. A C-13 study of the reaction of 2,4,6-triarylpyrylium cations with amines. Tetrahedron. 36:1643-1647. 1980
- Donchi KFBrownlee RTCDerrick PJ. Kinetic isotope effects in the unimolecular gas-phase decomposition of propane radical cations. Journal of the Chemical Society - Series Chemical Communications. 1061-1061. 1980
- Brownlee RTCCraik DJ. Temperature dependence of 19F chemical shifts in substituted benzyl fluorides.. Tetrahedron Letters. 21:1681-1684. 1980
- Bromilow JBrownlee RTCLopez VOTaft RW. Para-substituent C-13 chemical shifts in substituted benzenes. 1. Updating the .sigma.R0 scale and analysis of aprotic solvent effects. Journal of Organic Chemistry. 44:4766-4770. 1979
- Bromilow JBrownlee RTC. Investigating the .sigma.+ resonance scale using carbon-13 nuclear magnetic resonance shifts. Graphical representation of the dual substituent parameter equation. Journal of Organic Chemistry. 44:1261-1263. 1979
- Marker ACanty AJBrownlee RTC. Carbon-13 chemical shifts of some pyridines, 2,2'-bipyridyls and 1,10-phenanthrolines. Australian Journal of Chemistry: an international journal for chemical science. 31:1255-1255. 1978
- Andrewartha KABrownlee RTCPhillips DR. Fourier transform nuclear magnetic resonance determination of the degree of hydration of dilute solutions of biopolymers. Archives of Biochemistry and Biophysics. 185:423-428. 1978
- Brownlee RTCCanty AJMackay MF. The crystal structure of [MeHg(py)]+ [NO3]-, a complex with linear geometry for methylmercury(II). Australian Journal of Chemistry: an international journal for chemical science. 31:1933-1933. 1978
- Bromilow JBrownlee RTCCraik DJ. Substituent effects on the carbon-13 N.M.R. chemical shifts of side-chain carbons in aromatic systems. Australian Journal of Chemistry: an international journal for chemical science. 30:351-351. 1977
- Bromilow JBrownlee RTCPage AV. The origin of fluorine-19 and carbon-13 substituent chemical shifts in substituted benzyl fluorides. Tetrahedron Letters. 17:3055-3058. 1976
- Bromilow JBrownlee RTCTopsom RDTaft RW. Nonadditive carbon-13 substituent and solvent effects in substituted benzenes. Journal of the American Chemical Society. 98:2020-2022. 1976
- Brownlee RTCButt GChan MPTopsom RD. The nature of substituent electronic effects; the existence of the π-inductive effect. Journal of the Chemical Society, Perkin Transactions 2. 1486-1490. 1976
- Brownlee RTCDi Stefano JTopsom RD. Correlations between i.r. frequencies and substituent constants—2. Substituted benzenes. Spectrochimica Acta - Part A: Molecular Spectroscopy. 31:1685-1693. 1975
- Brownlee RTCTopsom RD. Correlations between i.r. frequencies and substituent constants—I. General considerations and aliphatic compounds. Spectrochimica Acta - Part A: Molecular Spectroscopy. 31:1677-1683. 1975
- Bromilow JBrownlee RTC. Reverse substituent chemical shift effects in the C-13 nmr shifts of substituted benzonitriles. Tetrahedron Letters. 16:2113-2114. 1975
- Brownlee RTCCameron DGTopsom RDKatritzky ARPozharsky AF. Infrared intensities as a quantitative measure of intramolecular interactions. Part XXV. Interaction between substituents in para-disubstituted benzenes. Journal of the Chemical Society, Perkin Transactions 2. 247-247. 1974
- Grindley TBJohnson KFKatritzky ARKeogh HJThirkettle CBrownlee RTCMunday JATopsom RD. Infrared intensities as a quantitative measure of intramolecular interactions. Part XXXII. Conjugation of the substituent and the triple bond in monosubstituted acetylenes. Journal of the Chemical Society, Perkin Transactions 2. 276-276. 1974
- Brownlee RTCCameron DGTopsom RDKatritzky ARSparrow AJ. The calculation and accurate measurement of infrared band intensities: the v8 and v19 vibrations of monosubstituted benzenes. Journal of Molecular Structure. 16:365-378. 1973
- Brownlee RTCTopsom RD. The correlation of ultraviolet absorption data with substituent constants. Spectrochimica Acta - Part A: Molecular Spectroscopy. 29:385-393. 1973
- Brownlee RTCMunday JTopsom RDKatritzky AR. CNDO/2 calculation of the absolute infra-red intensities of a series of monosubstituted ethylenes. Journal of the Chemical Society, Faraday Transactions 2: Molecular and Chemical Physics. 69:349-349. 1973
- Brownlee RTCDayal SKLyle JLTaft RW. Aprotic solvent effects on the fluorine nuclear magnetic resonance shifts of p-substituted fluorobenzenes. Journal of the American Chemical Society. 94:7208-7209. 1972
- Taagepera MHenderson W. G.Brownlee RTCBeauchamp JLHoltz DTaft RW. Gas-phase basicities and pyridine substituent effects. Journal of the American Chemical Society. 94:1369-1370. 1972
- Brownlee RTCTopsom RD. Analysis of spectral and reactivity data using hammett substituent constants. Tetrahedron Letters. 13:5187-5190. 1972
- Taft RWBrownlee RTC. A CNDO [complete neglect of differential overlap]/2 theoretical study of substituent effects on electronic distributions in fluorine molecular orbitals. Comparison with meta- and para-substituent fluorine nuclear magnetic resonance shifts. Journal of the American Chemical Society. 92:7007-7019. 1970
- Angelelli JMBrownlee RTCKatritzky ARTopsom RDYakhontov LN. Infrared intensities as a quantitative measure of intramolecular interactions. IX. Aryl derivatives of metalloids. Journal of the American Chemical Society. 91:4500-4504. 1969
- Brownlee RTCEnglish PJQKatritzky ARTopsom RD. Infrared intensities as a quantitative measure of intramolecular interaction. VII. .nu.13 Band near 1500 cm-1 in monosubstituted and para-disubstituted benzenes. Journal of Physical Chemistry. 73:557-564. 1969
- Brownlee RTCTaft RW. Concerning the sigma(sub R).deg. scale of substituent .pi. delocalization parameters. Theory and experiment. Journal of the American Chemical Society. 90:6537-6539. 1968
- Brownlee RTCHutchinson REJKatritzky ARTidwell TTTopsom RD. Infrared intensities as a quantitative measure of intramolecular interactions. III. Further monosubstituted benzenes and monosubstituted durenes. Journal of the American Chemical Society. 90:1757-1767. 1968
- Brownlee RTCKatritzky ARSinnott MVSzafran MYakhontov LTopsom RD. Calculation of infrared intensities of substituted benzenes by the hmo and cndo methods. Tetrahedron Letters. 9:5773-5776. 1968
- Brownlee RTCKatritzky ARTopsom RD. Infrared absorption of substituents in heterocyclic systems. Part X. Amine–imine tautomerism by infrared spectroscopy: further examples. Journal of the Chemical Society B: Physical Organic. 0:726-727. 1966
- Brownlee RTCKatritzky ARTopsom RD. Distortions of the π-Electron System in Monosubstituted Benzenes1. Journal of the American Chemical Society. 88:1413-1419. 1966
- Bacon NBoulton AJBrownlee RTCKatritzky ARTopsom RD. 973. Infrared absorption of substituents in heterocyclic systems. Part IX. Amine–imine tautomerism by infrared spectroscopy. Journal of the Chemical Society. 0:5230-5233. 1965
- Brownlee RTCKatritzky ARTopsom RD. Direct Infrared Determination of the Resonance Interaction in Monosubstituted Benzenes. Journal of the American Chemical Society. 87:3260-3261. 1965
- Katritzky ARWallis BBrownlee RTCTopsom RD. The tautomerism of heteroaromatic compounds with five-membered rings—VIII. Tetrahedron. 21:1681-1692. 1965
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chapter
-
conference paper
- Metzger RDang JNg CBrownlee RBergdahl MSeparovic F. Virginiamycin M1 conformation in aqueous systems. Abstracts of Papers, 229th ACS National Meeting. 1-1. 2005
- Box AKimura KPhillips DBrownlee R. NMR Studies of the Anti-Cancer Drug Barminomycin and the Covalent Complex formed with DNA.. Bioactive discovery in the new millennium. 3-3. 2003
- Dang JSeparovic FMetzger RBrownlee R. Structure of Virginiamycin VM1 Revisited.. 14TH World Congress on Animal Plant and Microbial Toxins . 141-141. 2003
- Dang JAurelio LHughes ABrownlee R. Structure of a Novel Antifungal Cyclic Depsipeptide, Petriellin A.. Bioactive discovery in the new millennium. P9-P9. 2003
- Dang JBlandford SSadek MGrobelny DBrownlee RTC. The solution structures of the HIV protease inhibitor DG35-VIII. Molecular Simulation. 827-843. 2002
- Dang JAurelio LHughes ABrownlee R. A Structural Study of Petriellin A: An Antifungal Compound.. 77-77. 2002
- Box AKimura KPhillips DBrownlee R. Barminomycin, as a Model for Anthracycline-DNA Adducts.. 61-61. 2002
- Thomas MGhabrial HOsicka TCooper MBrownlee R. Urine 1H-NMR Spectroscopy in Spontaneously Hypertensive Rats (SHR).. 65-65. 2002
- Aurelio LHughes ABrownlee R. Towards the Design and Synthesis of Antifungal Drugs Based on Petriellin A. 127-127. 2001
- Mackay MGale DWilshire JJames BBrownlee R. The Solution Study of the HIV 2000
Research
principal investigator on
Background
education and training
- B.A., Cambridge
- FRACI, .
- M.Sc, .
- PHD, East Anglia
Contact
full name
- Professor Robert Brownlee