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Dr Sarah Annesley Research Fellow, Physiology Anatomy & Microbiology

Co-leader of the Microbial Cell Biology Group.
My main areas of research are the study of neurological disorders and the role of the mitochondria in these diseases and the study of mitochondrial diseases. The major neurological conditions that we investigate are Parkinson's Disease, Alzheimer's Disease and ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome). We use two different model systems to help us decipher which signalling pathways are defective in these diseases and what proteins are involved. The first system is the simple eukaryotic slime mold or social amoeba. This is one of a handful of organisms recognised by the NIH for its use as a biomedical model. In this system we can manipulate genes thought to be involved in the disease process and uncover their normal physiological roles and the consequences of their dysfunction.
The second model system we use is lymphoblasts which we have created from patient's and healthy control blood cells. Here we can investigate the mitochondrial function and activity of key kinases and signalling proteins and compare their activity between the patient and control groups.

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