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Dr Tatiana Soares da Costa Research Fellow, Biochemistry

Resistance to current antibiotics and herbicides represents a major threat to global health and food security. Despite a continuous rise in resistance worldwide, no antibiotics or herbicides with a new mode of action have been introduced to the market in over 30 years. The overall focus of our laboratory is to define the structure, function and regulation of essential proteins in bacteria and plants to guide the development of new classes of antibiotics and herbicides.

Dr Soares da Costa has expertise in a number of biophysical and biochemical techniques including cloning, mutagenesis, protein expression, purification, kinetic and inhibition assays, circular dichroism spectroscopy, isothermal titration calorimetry, structure-based drug design, small angle X-ray scattering, X-ray crystallography and surface plasmon resonance. These techniques allow her to better understand how proteins and small molecule inhibitors interact, thus providing insights into the rational design of new inhibitors for pharmaceutical and agrochemical purposes.

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