selected publications
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academic article
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Pain CDO’Keefe GJAckermann UDore VVillemagne VLRowe CC. Human biodistribution and internal dosimetry of 4-[18F] fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors in the brain and heart.
EJNMMI Research.
10.
2020
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Walterfang MDi Biase MACropley VLScott AMO'Keefe GVelakoulis DPathmaraj KAckerman UPantelis C. Imaging of neuroinflammation in adult Niemann-Pick type C disease: a cross-sectional study.
Neurology.
94:e1716-e1725.
2020
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Wichmann CWGoh YWParslow ACRigopoulos AGuo NScott AMAckermann UWhite JM. Synthesis and validation of [18F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone.
EJNMMI Radiopharmacy and Chemistry.
5.
2020
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Huang YYPoniger STsai CLTochon-Danguy HJAckerman UYen RF. Three-step two-pot automated production of NCA [18F]FDOPA with FlexLab module.
Applied Radiation and Isotopes.
158:1-7.
2020
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Vargas HAKramer GMScott AMWeickhardt AMeier AAParada NBeattie BJHumm JLStaton KDZanzonico PBLyashchenko SKLewis JSYaqub MSosa REvan den Eertwegh AJDavis IDAckermann UPathmaraj KSchuit RCWindhorst ADChua SWeber WALarson SMScher HILammertsma AAHoekstra OMorris MJ. Reproducibility and Repeatability of Semiquantitative 18F-Fluorodihydrotestosterone Uptake Metrics in Castration-Resistant Prostate Cancer Metastases: A Prospective Multicenter Study.
Journal of Nuclear Medicine.
59:1516-1523.
2018
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North AJKaras JAMa MTBlower PJAckermann UWhite JMDonnelly PS. Rhenium and technetium-oxo complexes with thioamide derivatives of pyridylhydrazine bifunctional chelators conjugated to the tumour targeting peptides octreotate and cyclic-RGDfK.
Inorganic Chemistry: including bioinorganic chemistry.
56:9725-9741.
2017
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Laurens EYeoh SDRigopoulos AO'Keefe GJTochon-Danguy HJChong LWWhite JMScott AMAckermann U. Fluorine-18 radiolabeling of a nitrophenyl sulfoxide and its evaluation in an SK-RC-52 model of tumor hypoxia.
Journal of Labelled Compounds and Radiopharmaceuticals.
59:416-423.
2016
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Ackermann ULewis JSYoung KMorris MJWeickhardt ADavis IDScott AM. Fully automated synthesis of [18F]fluoro-dihydrotestosterone ([18F]FDHT) using the FlexLab module.
Journal of Labelled Compounds and Radiopharmaceuticals.
59:424-428.
2016
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Lee FTBurvenich IJGGuo NKocovski PTochon-Danguy HAckermann UO'Keefe GJGong SRigopoulos ALiu ZGan HKScott AM. L-Tyrosine Confers Residualizing Properties to a D-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies.
Molecular Imaging.
15:1-9.
2016
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Hayne DJNorth AJFodero-Tavoletti MWhite JMHung LWRigopoulos AMclean CAAdlard PAAckermann UTochon-Danguy HVillemagne VLBarnham KJDonnelly PS. Rhenium and technetium complexes that bind to amyloid-β plaques.
Dalton Transactions: an international journal of inorganic chemistry.
44:4933-4944.
2015
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North AJHayne DJSchieber CPrice KWhite ARCrouch PJRigopoulos AO'Keefe GJTochon-Danguy HScott AMWhite JMAckermann UDonnelly PS. Toward Hypoxia-Selective Rhenium and Technetium Tricarbonyl Complexes.
Inorganic Chemistry: including bioinorganic chemistry.
54:9594-9610.
2015
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Ardipradja KYeoh SDAlt KO'Keefe GRigopoulos AHowells DWScott AMPeter KAckerman UHagemeyer CE. Detection of activated platelets in a mouse model of carotid artery thrombosis with 18F-labeled single-chain antibodies.
Nuclear Medicine and Biology.
41:229-237.
2014
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Ackermann UPlougastel LWichmann CGoh YWYeoh SDPoniger SSTochon-Danguy HJScott AM. Fully automated synthesis and coupling of [18F]FBEM to glutathione using the iPHASE FlexLab module.
Journal of Labelled Compounds and Radiopharmaceuticals.
57:115-120.
2014
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Ackermann UPlougastel LGoh YWYeoh SDScott AM. Improved synthesis of [18F]FLETT via a fully automated vacuum distillation method for [18F]2-fluoroethyl azide purification.
Applied Radiation and Isotopes.
94:72-76.
2014
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Laurens EYeoh SDRigopoulos ACao DCartwright GAO'Keefe GJTochon-Danguy HJWhite JMScott AMAckermann U. Radiolabelling and evaluation of a novel sulfoxide as a PET imaging agent for tumor hypoxia.
Nuclear Medicine and Biology.
41:419-425.
2014
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Connell TUHayne DJAckermann UTochon-Danguy HJWhite JMDonnelly PS. Rhenium and technetium tricarbonyl complexes of 1,4-Substituted pyridyl-1,2,3-triazole bidentate 'click' ligands conjugated to a targeting RGD peptide.
Journal of Labelled Compounds and Radiopharmaceuticals.
57:262-269.
2014
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Alt KPaterson BMArdipradja KSchieber CBuncic GLim BPoniger SSJakoby BWang XOkeefe GJTochon-Danguy HJScott AMAckermann UPeter KDonnelly PSHagemeyer CE. Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets.
Molecular Pharmaceutics.
11:2855-2863.
2014
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Laurens EYeoh SDRigopoulos ACao DCartwright GAO'Keefe GJTochon-Danguy HJWhite JMScott AMAckermann U. Radiolabelling and evaluation of novel haloethylsulfoxides as PET imaging agents for tumor hypoxia.
Nuclear Medicine and Biology.
39:871-882.
2012
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Ly JVRowe CCVillemagne VLZavala JAMa HSahathevan RO'Keefe GGong SJGunawan RChurilov LSaunder TAckerman UTochon-Danguy HDonnan GA. Subacute ischemic stroke is associated with focal 11C PiB positron emission tomography retention but not with global neocortical aβ deposition.
Stroke.
43:1341-1346.
2012
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Ackermann UYeoh SDSachinidis JIPoniger SSScott AMTochon-Danguy HJ. A simplified protocol for the automated production of succinimidyl 4-[ 18F]fluorobenzoate on an IBA Synthera module.
Journal of Labelled Compounds and Radiopharmaceuticals.
54:671-673.
2011
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Villemagne VLOng KMulligan RSHoll GPejoska SJones GO'Keefe GAckerman UTochon-Danguy HChan JGReininger CBFels LPutz BRohde BMasters CLRowe CC. Amyloid imaging with 18F-florbetaben in Alzheimer disease and other dementias.
Journal of Nuclear Medicine.
52:1210-1217.
2011
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Villemagne VLOkamura NPejoska SDrago JMulligan RSChételat GAckermann UO'Keefe GJones GGong STochon-Danguy HKung HFMasters CLSkovronsky DMRowe CC. In vivo assessment of vesicular monoamine transporter type 2 in dementia with lewy bodies and alzheimer disease.
Archives of Neurology.
68:905-912.
2011
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Villemagne VLPike KEChételat GEllis KAMulligan RSBourgeat PAckermann UJones GSzoeke CSalvado OMartins RO'Keefe GMathis CAKlunk WEAmes DMasters CLRowe CC. Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease.
Annals of Neurology.
69:181-192.
2011
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Ackermann USigmund DYeoh SDRigopoulos AO'Keefe GCartwright GWhite JScott AMTochon-Danguy HJ. Synthesis of 2-[(4-[ 18F]Fluorobenzoyloxy)methyl]-1,4- naphthalenedione from 2-hydroxymethyl 1,4-naphthoquinone and 4-[ 18F]fluorobenzoic acid using dicyclohexyl carbodiimide.
Journal of Labelled Compounds and Radiopharmaceuticals.
54:788-794.
2011
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Ackermann UO'Keefe GLee STRigopoulos ACartwright GSachinidis JIScott AMTochon-Danguy HJ. Synthesis of a [18F]fluoroethyltriazolylthymidine radiotracer from [18F]2-fluoroethyl azide and 5-ethynyl-2′-deoxyuridine.
Journal of Labelled Compounds and Radiopharmaceuticals.
54:260-266.
2011
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Ly JVRowe CCVillemagne VLZavala JAMa HO'Keefe GGong SJGunawan RChurilov LSaunder TAckerman UTochon-Danguy HDonnan GA. Cerebral β-amyloid detected by Pittsburgh compound B positron emission topography predisposes to recombinant tissue plasminogen activator-related hemorrhage.
Annals of Neurology.
68:959-962.
2010
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Olver JSO'Keefe GJones GRBurrows GDTochon-Danguy HJAckermann UScott AMNorman TR. Dopamine D1 receptor binding in the anterior cingulate cortex of patients with obsessive–compulsive disorder.
Psychiatry Research: Neuroimaging.
183:85-88.
2010
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Ly JVDonnan GAVillemagne VLZavala JAMa HO'Keefe GGong SJGunawan RMSaunder TAckerman UTochon-Danguy HChurilov LPhan TGRowe CC. 11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage.
Neurology.
74:487-493.
2010
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Okamura NVillemagne VLDrago JPejoska SDhamija RKMulligan RSEllis JRAckermann UO'Keefe GJones GKung HFPontecorvo MJSkovronsky DRowe CC. In Vivo Measurement of Vesicular Monoamine Transporter Type 2 Density in Parkinson Disease with 18F-AV-133.
Journal of Nuclear Medicine.
51:223-228.
2010
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Olver JSO'Keefe GJones GRBurrows GDTochon-Danguy HJAckermann UScott ANorman TR. Dopamine D1 receptor binding in the striatum of patients with obsessive–compulsive disorder.
Journal of Affective Disorders.
114:321-326.
2009
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O'Keefe GJSaunder THNg SAckerman UTochon-Danguy HJChan JGGong SDyrks TLindemann SHoll GDinkelborg LVillemagne VRowe CC. Radiation Dosimetry of -Amyloid Tracers 11C-PiB and 18F-BAY94-9172.
Journal of Nuclear Medicine.
50:309-315.
2009
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Villemagne VLPike KEDarby DMaruff PSavage GNg SAckermann UCowie TFCurrie JChan SGJones GTochon-Danguy HO’Keefe GMasters CLRowe CC. Aβ deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease.
Neuropsychologia.
46:1688-1697.
2008
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Rowe CCAckerman UBrowne WMulligan RPike KLO'Keefe GTochon-Danguy HChan GBerlangieri SUJones GDickinson-Rowe KLKung HPZhang WKung MPSkovronsky DDyrks THoll GKrause SFriebe MLehman LLindemann SDinkelborg LMMasters CLVillemagne VL. Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism.
Lancet Neurology.
7:129-135.
2008
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Rowe CCNg SAckermann UGong SJPike KSavage GCowie TFDickinson KLMaruff PDarby DSmith CWoodward MMerory JTochon-Danguy HO'Keefe GKlunk WEMathis CAPrice JCMasters CLVillemagne VL. Imaging -amyloid burden in aging and dementia.
Neurology.
68:1718-1725.
2007
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Ng SVillemagne VLBerlangieri SLee S-TCherk MGong SJAckermann USaunder TTochon-Danguy HJones GSmith CO'Keefe GMasters CLRowe CC. Visual Assessment Versus Quantitative Assessment of 11C-PIB PET and 18F-FDG PET for Detection of Alzheimer's Disease.
Journal of Nuclear Medicine.
48:547-552.
2007
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Falzon CLAckermann USpratt NTochon-Danguy HJWhite JHowells DScott AM. F-18 labelledN,N-bis-haloethylamino-phenylsulfoxides — a new class of compounds for the imaging of hypoxic tissue.
Journal of Labelled Compounds and Radiopharmaceuticals.
49:1089-1103.
2006
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Spratt NJAckerman UTochon-Danguy HJDonnan GAHowells DW. Characterization of Fluoromisonidazole Binding in Stroke.
Stroke.
37:1862-1867.
2006
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Ackermann UBlanc PFalzon CLIssa WWhite JTochon-Danguy HJSachinidis JIScott AM. Synthesis of 11C labelled methyl esters: transesterification of enol esters versus BF3 catalysed esterification—a comparative study.
Radiation Physics and Chemistry.
75:48-52.
2006
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Ackermann UTochon-Danguy HJNerrie MNice ECSachinidis JIScott AM. Synthesis, 11C labeling and biological properties of derivatives of the tyrphostin AG957.
Nuclear Medicine and Biology.
32:323-328.
2005
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Issa WTochon-Danguy HJLambert JSachinidis JIAckermann ULiu ZScott AM. Synthesis and evaluation of a thymidine analog for positron emission tomography study of tumor DNA proliferation in vivo.
Nuclear Medicine and Biology.
31:839-849.
2004
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Ackermann UTochon-Danguy HJScott AM. BF3 etherate catalysed formation of[11C]methyl esters: a novel radiolabelling technique.
Journal of Labelled Compounds and Radiopharmaceuticals.
47:523-530.
2004
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Saita KChen MSpratt NJPorritt MJLiberatore GTRead SJLevi CRDonnan GAAckermann UTochon-Danguy HJSachinidis JIHowells DW. Imaging the Ischemic Penumbra with
18
F-Fluoromisonidazole in a Rat Model of Ischemic Stroke.
Stroke.
35:975-980.
2004
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Ackermann UTochon-Danguy HJYoung KSachinidis JIGordon Chan JScott AM. 11C labelling of AG957?a potential tyrphostin radiotracer for PET.
Journal of Labelled Compounds and Radiopharmaceuticals.
45:157-165.
2002
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Gleiter RAckermann UOeser TIrngartinger H. Synthesis and Properties of 4,4,9,9-Tetramethyl-1-oxa-cycloundecane-5,6,7,8-tetrone and 5,5,10,10-Tetramethyl-1-oxa-cyclotridecane-6,7,8,9-tetrone.
Chemistry: A European Journal.
2:271-277.
1996
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Gleiter RStaib MAckermann U. Synthesis of 5,5,10,10-tetramethyl-1-oxacyclotridecane-6,7,8,9-tetrone – on the mechanism of the Rubottom reaction.
Liebigs Annales.
1995:1655-1661.
1995
Full text if available
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Pain CDO’Keefe GJAckermann UDore VVillemagne VLRowe CC. Human biodistribution and internal dosimetry of 4-[18F] fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors in the brain and heart.
EJNMMI Research.
10.
2020
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conference paper
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Gan HCher LInglis PLwin ZLau EWichmann CAckermann UCoombs NRemen KGuo NLee STGong SPalmer JBPathmaraj KO'Keefe GScott FDay BWBoyd AWThomas PDurrant CScott AM. Abstract CT063: Preliminary findings of a Phase I safety and bioimaging trial of KB004 (ifabotuzumab) in patients with glioblastoma.
Cancer Research.
2019
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McDonald AGoh YWWhite JMScott AAckermann U. Investigation of automated radiofluorination methods for oxidatively sensitive aryl systems.
European Journal of Nuclear Medicine and Molecular Imaging.
S725-S726.
2019
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Wichmann CParslow AAckermann URigopoulos AScott AMWhite J. Abstracts.
Internal Medicine Journal.
7-19.
2018
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McDonald AParslow AGoh YWWhite JScott AMAckermann U. HARNESSING ANALOGUES OF THE ONCRASIN-1 FOR RADIOTRACER IMAGING OF TARGETED THERAPY RESISTANCE.
Internal Medicine Journal.
12-13.
2018
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Parslow AWichmann CRigopoulos AAckermann UWhite JMScott A. Development of small-molecule mTORC1 radiotracers for evaluation of targeted therapy resistance using PET.
Cancer Research.
2018
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Wichmann CParslow ARigopoulos AAckermann UWhite JMScott A. Preclinical evaluation of a mTOR specific PET ligand in a RAD001 sensitive/resistant breast cancer model system.
European Journal of Nuclear Medicine and Molecular Imaging.
S190-S191.
2018
-
Gan HCher LInglis PLwin ZLau EWichmann CAckermann UCoombs NRemen KGuo NLee STGong SPalmer JBPathmaraj KO'Keefe GScott FDay BWBoyd AWThomas PDurrant CScott AM. Abstract CT063: Preliminary findings of a Phase I safety and bioimaging trial of KB004 (ifabotuzumab) in patients with glioblastoma.
Cancer Research.
2019