subject area of

• A Division-Linked Mechanism for the Rapid Generation of Ig-Secreting Cells from Human Memory B Cells  Academic Article
• A comparative study of the phenotype and proliferative capacity of peripheral blood (PB) CD34⁺ cells mobilized by four different protocols and those of steady-phase PB and bone marrow CD34⁺ cells  Academic Article
• A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin  Academic Article
• A novel receptor involved in T-cell activation  Academic Article
• A phase 1B trial of humanized monoclonal antibody M195 (anti-CD33) in myeloid leukemia: Specific targeting without immunogenicity  Academic Article
• A robust human T-cell culture method suitable for monitoring CD8+ and CD4+ T-cell responses from cancer clinical trial samples  Academic Article
• Acquiring signalling specificity from the cytokine receptor gp130  Academic Article
• Activated-platelet targeting of CD39 as a potential way forward: The quest for efficient antithrombotic therapy without associated bleeding complications  Academic Article
• Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice  Academic Article
• Affinity Maturation of Leukemia Inhibitory Factor and Conversion to Potent Antagonists of Signaling  Academic Article
• An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-Activated Macrophage Profile  Academic Article
• An FcγRIIa-binding peptide that mimics the interaction between FcγRIIa and IgG  Academic Article
• An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors.  Academic Article
• Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions.  Academic Article
• Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death  Academic Article
• B-Cell Activation by Helper T-Cell Membranes  Academic Article
• BAFF selectively enhances the survival of plasmablasts generated from human memory B cells  Academic Article
• Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.  Academic Article
• C-reactive protein and FcγRIIa functional polymorphisms are not associated with clinical presentation of stable and unstable angina  Academic Article
• CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages  Academic Article
• CD4+ CD25+ Regulatory T Cells Modulate the T-Cell and Antibody Responses in Helicobacter-Infected BALB/c Mice  Academic Article
• CD40 ligand-CD40 interaction in Ig isotype switching in mature and immature human B cells  Academic Article
• CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2  Academic Article
• CEACAM1: An adhesion molecule that limits blood-brain barrier damage by neutrophils after stroke  Academic Article
• Characterization of a Distinct Population of Circulating Human Non-Adherent Endothelial Forming Cells and Their Recruitment via Intercellular Adhesion Molecule-3  Academic Article
• Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse  Academic Article
• Cleavage of the Human C5A Receptor by Protienases Derived from Porphyromonas Gingivalis  Academic Article
• Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo  Academic Article
• Contact-mediated signals and cytokines involved in B-cell activation and isotype switching in pre-B and mature B cells  Academic Article
• Cross-Talk between Activated Human NK Cells and CD4+ T Cells via OX40-OX40 Ligand Interactions  Academic Article
• Crystal structure of the human leukocyte Fc receptor, FcγRIIa  Academic Article
• Cutaneous presentation on the eyelid of primary, systemic, CD30+, anaplastic lymphoma kinase (ALK)-negative, anaplastic large-cell lymphoma (ALCL)  Academic Article
• Cysticercosis: cellular immune responses during primary and secondary infection  Academic Article
• DNA vaccines in sheep: CTLA-4 mediated targeting and CpG motifs enhance immunogenicity in a DNA prime/protein boost strategy  Academic Article
• Defective Gp130-Mediated Signal Transducer and Activator of Transcription (Stat) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation  Academic Article
• Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?  Academic Article
• Determination of the Disulfide Structure andN-Glycosylation Sites of the Extracellular Domain of the Human Signal Transducer gp130  Academic Article
• Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia–reperfusion injury  Academic Article
• Differential Regulation of Gastric Tumor Growth by Cytokines That Signal Exclusively Through the Coreceptor gp130  Academic Article
• Direct analysis of FACS-sorted hemopoietic cell fractions using FISH  Academic Article
• Distinct Roles for Leukemia Inhibitory Factor Receptor α-Chain and gp130 in Cell Type-specific Signal Transduction  Academic Article
• Disulfide Bond Structure andN-Glycosylation Sites of the Extracellular Domain of the Human Interleukin-6 Receptor  Academic Article
• Effects of Mutations in the Cytoplasmic Domain of Integrin β1 to Talin Binding and Cell Spreading  Academic Article
• Effects of ovariectomy and estrogen on ischemia-reperfusion injury in hindlimbs of female rats  Academic Article
• Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells  Academic Article
• Engagement of the Signaling Lymphocytic Activation Molecule (SLAM) on Activated T Cells Results in IL-2-Independent, Cyclosporin A-Sensitive T Cell Proliferation and IFN-γ Production  Academic Article
• Evaluation of a monoclonal IgM antibody for purging of bone marrow for autologous transplantation  Academic Article
• Evidence of Platelet Activation at Medically Used Hypothermia and Mechanistic Data Indicating ADP as a Key Mediator and Therapeutic Target  Academic Article
• Ex Vivo Hematopoietic Progenitor Cell Expansion  Academic Article
• Ex vivo expansion and maturation of peripheral blood CD34⁺ cells into the myeloid lineage  Academic Article
• FX-06, a fibrin-derived Bβ15-42 peptide for the potential treatment of reperfusion injury following myocardial infarction  Academic Article
• Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice  Academic Article
• Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130  Academic Article
• Granulocyte colony stimulating factor expands hematopoietic stem cells within the central but not endosteal bone marrow region  Academic Article
• Helper T cells: delivery of cell contact and lymphokine-dependent signals to B cells  Academic Article
• Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling  Academic Article
• High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130  Academic Article
• Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain  Academic Article
• Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct  Academic Article
• IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand  Academic Article
• IL-4 induces germ-line IgE heavy chain gene transcription in human fetal pre-B cells: Evidence for differential expression of functional IL-4 and IL- 13 receptors during B cell ontogeny  Academic Article
• Identification and Characterization of Two Distinct Truncated Forms of gp130 and a Soluble Form of Leukemia Inhibitory Factor Receptor α-Chain in Normal Human Urine and Plasma  Academic Article
• Identification of homeobox genes expressed in human haemopoietic progenitor cells  Academic Article
• Identification of residues in the first domain of human Fcα receptor essential for interaction with IgA  Academic Article
• Identification, Purification, and Characterization of a Soluble Interleukin (IL)-13-binding Protein  Academic Article
• Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression  Academic Article
• Immunophenotypic changes induced on human HL60 leukaemia cells by 1α,25-dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol-13-acetate  Academic Article
• Impaired microglia process dynamics post-stroke are specific to sites of secondary neurodegeneration  Academic Article
• In vitro Study of a Novel Stent Coating Using Modified CD39 Messenger RNA to Potentially Reduce Stent Angioplasty-Associated Complications  Academic Article
• Increased Expression of CD27 on Activated Human Memory B Cells Correlates with Their Commitment to the Plasma Cell Lineage  Academic Article
• Increased expression of signaling lymphocytic activation molecule in patients with rheumatoid arthritis and its role in the regulation of cytokine production in rheumatoid synovium  Academic Article
• Increased recruitment of hematopoietic progenitor cells underlies the ex vivo expansion potential of FLT3 ligand  Academic Article
• Induction of Specific T-Cell Responses, Opsonizing Antibodies, and Protection against Plasmodium chabaudi adami Infection in Mice Vaccinated with Genomic Expression Libraries Expressed in Targeted and Secretory DNA Vectors  Academic Article
• Influence of Interleukin-6 (IL-6) Dimerization on Formation of the High Affinity Hexameric IL-6·Receptor Complex  Academic Article
• Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.  Academic Article
• Interleukin-6: Structure-function relationships  Academic Article
• Intrinsic Differences in the Proliferation of Naive and Memory Human B Cells as a Mechanism for Enhanced Secondary Immune Responses  Academic Article
• Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors  Academic Article
• Local immunity in the mammary gland  Academic Article
• Lymphocyte subpopulations in pyogranulomas of caseous lymphadenitis  Academic Article
• Lymphocyte surface marker and cytokine expression in peripheral and mucosal lymph nodes  Academic Article
• M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss, and elevated blood pressure  Academic Article
• Mac-1 directly binds to the endothelial protein C-receptor: a link between the protein C anticoagulant pathway and inflammation?  Academic Article
• Mammary Gland Remodeling Depends on gp130 Signaling through Stat3 and MAPK  Academic Article
• Melanoma vaccines: developments over the past 10 years  Academic Article
• Meta-Analysis of Microarray Studies Reveals a Novel Hematopoietic Progenitor Cell Signature and Demonstrates Feasibility of Inter-Platform Data Integration  Academic Article
• Microglia in human retina: A heterogeneous population with distinct ontogenies  Academic Article
• Modulation of the resistance of a human endothelial cell line by human retinal glia  Academic Article
• Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): Differential expression and responsiveness in Th1 and Th2 cells  Academic Article
• Molecular characterisation of aromatase inhibitor-resistant advanced breast cancer: the phenotypic effect of ESR1 mutations  Academic Article
• Monoclonal antibodies and synthetic peptides define the active site of FcεRI and a potential receptor antagonist  Academic Article
• Monoclonal antibody BB9 raised against bone marrow stromal cells identifies a cell-surface glycoprotein expressed by primitive human hemopoietic progenitors  Academic Article
• Mucin-like Molecules as Modulators of the Survival and Proliferation of Primitive Hematopoietic Cells  Academic Article
• Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of Legionella pneumophila  Academic Article
• Native LDL promotes differentiation of human monocytes to macrophages with an inflammatory phenotype  Academic Article
• Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2  Academic Article
• PSGL-1-Mediated Adhesion of Human Hematopoietic Progenitors to P-Selectin Results in Suppression of Hematopoiesis  Academic Article
• Parathyroid Hormone-Related Protein Protects against Mammary Tumor Emergence and Is Associated with Monocyte Infiltration in Ductal Carcinoma In situ  Academic Article
• Peripheral blood is a source of BCR-ABL-negative pre-progenitors in early chronic phase chronic myeloid leukemia  Academic Article
• Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential  Academic Article
• Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis  Academic Article
• Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice  Academic Article
• Resident CD8+ and Migratory CD103+ Dendritic Cells Control CD8 T Cell Immunity during Acute Influenza Infection  Academic Article
• Reversal of Human Allergic T Helper 2 Responses by Engagement of Signaling Lymphocytic Activation Molecule  Academic Article
• Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells  Academic Article
• SLAM and its role in T cell activation and Th cell responses  Conference Paper
• Serum sTWEAK concentrations and risk of developing type 2 diabetes in a high cardiovascular risk population: A nested case-control study  Academic Article
• Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34⁺ hemopoietic progenitor cells  Academic Article
• Soluble and Membrane-bound Forms of Signaling Lymphocytic Activation Molecule (SLAM) Induce Proliferation and Ig Synthesis by Activated Human B Lymphocytes  Academic Article
• Solution Structure of Ectodomains of the Insulin Receptor Family: The Ectodomain of the Type 1 Insulin-Like Growth Factor Receptor Displays Asymmetry of Ligand Binding Accompanied by Limited Conformational Change  Academic Article
• Stoichiometry of the Interleukin-6 High Affinity Receptor Complex  Conference Paper
• Surface profiling of extracellular vesicles from plasma or ascites fluid using DotScan antibody microarrays  Chapter
• Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease  Academic Article
• The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation  Academic Article
• The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury  Academic Article
• The Immunoglobulin-like Module of gp130 Is Required for Signaling by Interleukin-6, but Not by Leukemia Inhibitory Factor  Academic Article
• The Interleukin-6 (IL-6) Partial Antagonist (Q159E,T162P)IL-6 Interacts with the IL-6 Receptor and gp130 but Fails to Induce a Stable Hexameric Receptor Complex  Academic Article
• The N-Terminus of gp130 is Critical for the Formation of the High-Affinity Interleukin-6 Receptor Complex  Academic Article
• The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin  Academic Article
• The role of T/B cell interactions and cytokines in the regulation of human IgE synthesis  Academic Article
• The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression?  Academic Article
• The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover  Academic Article
• The self peptide annexin II (208-223) presented by dendritic cells sensitizes autologous CD4+ T lymphocytes to recognize melanoma cells  Academic Article
• The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis  Academic Article
• The use of the APAAP technique as a rapid indicator of peripheral blood progenitor cell levels  Academic Article
• Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax  Academic Article
• gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways  Academic Article