subject area of

• (α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xLRecognition:  Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions  Academic Article
• 2-Methoxyestradiol – a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents  Academic Article
• 8 Apoptosis, haemopoiesis and leukaemogenesis  Academic Article
• A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs  Academic Article
• A Functional Yeast Survival Screen of Tumor-Derived cDNA Libraries Designed to Identify Anti-Apoptotic Mammalian Oncogenes  Academic Article
• A QCM-D and SAXS Study of the Interaction of Functionalised Lyotropic Liquid Crystalline Lipid Nanoparticles with siRNA  Academic Article
• A Structural Investigation of NRZ Mediated Apoptosis Regulation in Zebrafish  Academic Article
• A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak  Academic Article
• A T cell-specific knockout reveals an important role for protease-activated receptor 2 in lymphocyte development  Academic Article
• A comparison of novel organoiridium(III) complexes and their ligands as a potential treatment for prostate cancer  Academic Article
• A conformational change of C-reactive protein in burn wounds unmasks its proinflammatory properties  Academic Article
• A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy  Academic Article
• A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma  Academic Article
• A novel Apaf-1–independent putative caspase-2 activation complex  Academic Article
• A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation  Academic Article
• A novel influenza A virus mitochondrial protein that induces cell death  Academic Article
• A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure  Academic Article
• A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis  Academic Article
• ABT-737, proving to be a great tool even before it is proven in the clinic  Academic Article
• AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC  Academic Article
• APOPTOSIS: A Cinderella Caspase Takes Center Stage  Academic Article
• ATF3 Repression of BCL-X L Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types  Academic Article
• Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells  Academic Article
• Absence of caveolin-1 alters heat shock protein expression in spontaneous mammary tumors driven by Her-2/neu expression  Academic Article
• Activation of clinically used anthracyclines by the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate  Academic Article
• Activation of physiological cell death mechanisms by a necrosis-causing agent  Academic Article
• Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death  Academic Article
• Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner  Academic Article
• Alterations in the apoptotic machinery and their potential role in anticancer drug resistance  Academic Article
• Alternative oxidase: a target and regulator of stress responses  Academic Article
• Alternative splicing of Bim and Erk-mediated Bim EL phosphorylation are dispensable for hematopoietic homeostasis in vivo  Academic Article
• An Essential Role for the Caspase Dronc in Developmentally Programmed Cell Death inDrosophila  Academic Article
• An appointment with death,: 2013 Cold Spring Harbor Asia meeting 'Mechanisms and Functions of Non-Apoptotic Cell Death'  Conference Paper
• An evolutionary perspective on apoptosis  Academic Article
• An optimized method for establishing high purity murine CD8+ T cell cultures  Academic Article
• Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells  Academic Article
• Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism  Academic Article
• Analysis of the Role of bcl-2 in Apoptosis  Academic Article
• Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma  Academic Article
• Angiotensin II Type 2 Receptor Stimulation Initiated After Stroke Causes Neuroprotection in Conscious Rats  Academic Article
• Another twist in the on and off affair between cell suicide and inflammation  Editorial Article
• Antagonism of IAPs enhances CAR T-cell efficacy  Academic Article
• Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells  Academic Article
• Anti‐TIM‐1 Monoclonal Antibody (RMT1‐10) Attenuates Atherosclerosis By Expanding IgM‐producing B1a Cells  Academic Article
• Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die  Academic Article
• Apoptogenic factors released from mitochondria  Academic Article
• Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak  Academic Article
• Apoptosis Timeline  Academic Article
• Apoptosis and the immune system  Academic Article
• Apoptosis and toxicology—what relevance?  Academic Article
• Apoptosis genes and autoimmunity  Academic Article
• Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis  Academic Article
• Apoptosis in the development and treatment of cancer  Academic Article
• Apoptosis induced in synchronized human immunodeficiency virus type 1-infected primary peripheral blood mononuclear cells is detected after the peak of CD4+ T-lymphocyte loss and is dependent on the tropism of the gp120 envelope glycoprotein  Academic Article
• Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2  Academic Article
• Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome  Academic Article
• Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax  Academic Article
• Apoptosis: A sticky business  Academic Article
• Apoptotic Mechanisms After Cerebral Ischemia  Academic Article
• Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction  Academic Article
• Apoptotic cell clearance: basic biology and therapeutic potential  Academic Article
• Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane  Academic Article
• Apoptotic, necrotic, or fused tumor cells: An equivalent source of antigen for dendritic cell loading  Academic Article
• Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death.  Academic Article
• Arsenic Trioxide Induces Apoptosis of Human Monocytes during Macrophagic Differentiation through Nuclear Factor-κB-Related Survival Pathway Down-Regulation  Academic Article
• Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells  Academic Article
• Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis  Academic Article
• Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: HYPOTHESIS: APOPTOSIS CAUSED BY CYTOTOXINS REPRESENTS A DEFENSIVE RESPONSE THAT EVOLVED TO COMBAT INTRACELLULAR PATHOGENS  Conference Paper
• Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion  Academic Article
• BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis  Academic Article
• BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux  Academic Article
• BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals  Academic Article
• BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival  Academic Article
• BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy  Academic Article
• BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines  Academic Article
• BH3-Only proteins in health and disease  Chapter
• BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes  Academic Article
• BH3-only proteins: a 20-year stock-take  Academic Article
• BMPs regulate differentiation of a putative visceral endoderm layer within human embryonic stem-cell-derived embryoid bodies  Academic Article
• Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains  Academic Article
• Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis  Academic Article
• Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function  Academic Article
• Bcl-2 Prevents Apoptosis Induced by Perforin and Granzyme B, but Not That Mediated by Whole Cytotoxic Lymphocytes  Academic Article
• Bcl-2 and thermotolerance cooperate in cell survival  Academic Article
• Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor  Academic Article
• Bcl-2 family proteins: The sentinels of the mitochondrial apoptosis pathway  Academic Article
• Bcl-2 in Cell Cycle Regulation  Academic Article
• Bcl-2–regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9  Academic Article
• Bcl-x(L) inhibition enhances Dinaciclib-induced cell death in soft-tissue sarcomas  Academic Article
• Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax  Academic Article
• Bim Links ER Stress and Apoptosis in Cells Expressing Mutant SOD1 Associated with Amyotrophic Lateral Sclerosis  Academic Article
• Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic  Academic Article
• Bioenergetic differences selectively sensitize tumorigenic liver progenitor cells to a new gold(I) compound  Academic Article
• Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity  Academic Article
• Bone Morphogenetic Protein-7 Inhibits Telomerase Activity, Telomere Maintenance, and Cervical Tumor Growth  Academic Article
• Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199  Academic Article
• Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions  Academic Article
• Butyrate-induced apoptotic cascade in colonic carcinoma cells: Modulation of the β-catenin-Tcf pathway and concordance with effects of sulindac and trichostatin A but not curcumin  Academic Article
• C-reactive protein: How conformational changes influence inflammatory properties  Academic Article
• CD4 ⁺ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4 ⁺ T cells  Academic Article
• CED-4—The Third Horseman of Apoptosis  Academic Article
• CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)−mediated apoptosis  Academic Article
• Calsenilin contributes to neuronal cell death in ischemic stroke  Academic Article
• Cancer and programmed cell death  Conference Paper
• Cardioprotection Induced by Adenosine A1 Receptor Agonists in a Cardiac Cell Ischemia Model Involves Cooperative Activation of Adenosine A2A and A2B Receptors by Endogenous Adenosine  Academic Article
• Cardioprotection from ischaemia–reperfusion injury by a novel flavonol that reduces activation of p38 MAPK  Academic Article
• Caspase-14: a new player in cytotrophoblast differentiation  Academic Article
• Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9  Academic Article
• Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7  Academic Article
• Caspase-2: controversial killer or checkpoint controller?  Academic Article
• Caspase-8 Cleaves Histone Deacetylase 7 and Abolishes Its Transcription Repressor Function  Academic Article
• Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis  Academic Article
• Caspases and apoptosis – biology and terminology  Academic Article
• Cell Death in Development  Academic Article
• Cell death in the origin and treatment of cancer  Academic Article
• Cell death regulation by the mammalian IAP antagonist Diablo/Smac  Academic Article
• Cell death: Shadow Baxing  Academic Article
• Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment  Academic Article
• Cellular Mechanisms of Risk and Transformation  Conference Paper
• Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin  Academic Article
• Characterization of ABBV-221, a Tumor-Selective EGFR-Targeting Antibody Drug Conjugate  Academic Article
• Characterization of the ectromelia virus serpin, SPI-2 The GenBank accession number for ectromelia virus SPI-2 is AF219903.  Academic Article
• Characterization of theDrosophilaCaspase, DAMM  Academic Article
• Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice  Academic Article
• Chemo-sensitisation of HeLa cells to Etoposide by a Benzoxazine in the absence of DNA-PK inhibition  Academic Article
• Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level  Academic Article
• Circulating HtrA2 after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: A potential novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury  Letter
• Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.  Academic Article
• Cloning of Mouse RP-8 cDNA and Its Expression During Apoptosis of Lymphoid and Myeloid Cells  Academic Article
• Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes  Academic Article
• Colonic Cell Proliferation, Differentiation, and Apoptosis  Conference Paper
• Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways  Academic Article
• Combined gene expression and proteomic analysis of EGF induced apoptosis in A431 cells suggests multiple pathways trigger apoptosis  Academic Article
• Computational Systems Biology Approach Predicts Regulators and Targets of microRNAs and Their Genomic Hotspots in Apoptosis Process  Academic Article
• Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer  Academic Article
• Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands  Academic Article
• Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts  Academic Article
• Control of Apoptosis in Hematopoietic Cells by the Bcl-2 Family of Proteins  Conference Paper
• Controlling TRAIL-mediated caspase-3 activation  Academic Article
• Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design  Academic Article
• Cre transgene results in global attenuation of the cAMP/PKA pathway  Academic Article
• CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.  Academic Article
• Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family  Academic Article
• Cyclic‐AMP‐dependent protein kinase A regulates apoptosis by stabilizing the BH3‐only protein Bim  Academic Article
• Cycloheximide can induce Bax/Bak dependent myeloid cell death independently of multiple BH3-only proteins  Academic Article
• Cytoplasmic p53 is not required for PUMA-induced apoptosis  Academic Article
• Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis  Academic Article
• DR5 and caspase-8 are dispensable in ER stress-induced apoptosis  Academic Article
• Death in the snow: report on Keystone Conference on ‘Apoptosis and Programmed Cell Death’ at Breckenridge, CO, April 6–11th 1999  Conference Paper
• Death to flies: Drosophila as a model system to study programmed cell death  Academic Article
• Debcl, a Proapoptotic Bcl-2 Homologue, Is a Component of the Drosophila melanogaster Cell Death Machinery  Academic Article
• Deerpox Virus Encodes an Inhibitor of Apoptosis That Regulates Bak and Bax  Academic Article
• Defining the morphologic features and products of cell disassembly during apoptosis  Letter
• Defining the role of cytoskeletal components in the formation of apoptopodia and apoptotic bodies during apoptosis  Academic Article
• Deglycosylated bleomycin induces apoptosis in lymphoma cell via c-jun NH2-terminal kinase but not reactive oxygen species  Academic Article
• Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression  Academic Article
• Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells  Academic Article
• Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance  Academic Article
• Determining the contents and cell origins of apoptotic bodies by flow cytometry  Academic Article
• Developmental and Neuropathological Consequences of Ductal Ligation in the Preterm Baboon  Academic Article
• Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways  Academic Article
• Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9  Academic Article
• Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2  Academic Article
• Differential Regulation of Gastric Tumor Growth by Cytokines That Signal Exclusively Through the Coreceptor gp130  Academic Article
• Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function  Academic Article
• Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke  Academic Article
• Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP  Academic Article
• Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays  Academic Article
• Disassembly of dying cells in diverse organisms  Academic Article
• Disassembly of the Dying: Mechanisms and Functions  Academic Article
• Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes  Academic Article
• Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes  Academic Article
• Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL  Academic Article
• Dissection of Protease-Activated Receptor-1-Dependent and -Independent Responses to Thrombin in Skeletal Myoblasts  Academic Article
• Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques  Academic Article
• Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: Initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (Δψ(m))  Academic Article
• Disturbed oligodendrocyte development and recovery from hypomyelination in a c-myc transgenic mouse mutant  Academic Article
• Divergent phenotypic patterns and commitment to apoptosis of Caco-2 cells during spontaneous and butyrate-induced differentiation  Academic Article
• Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells  Academic Article
• Doxorubicin-DNA Adducts Induce a Non-Topoisomerase II–Mediated Form of Cell Death  Academic Article
• Drosophila SPARC Is a Self-Protective Signal Expressed by Loser Cells during Cell Competition  Academic Article
• Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition  Academic Article
• EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival  Academic Article
• ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim  Academic Article
• ER Stress and UPR in Familial Amyotrophic Lateral Sclerosis  Academic Article
• ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis  Academic Article
• Early origins of heart disease: Low birth weight and determinants of cardiomyocyte endowment  Academic Article
• Early work on the function of Bcl-2, an interview with David Vaux  Academic Article
• Effect of immunosuppressive agents on hepatocyte apoptosis post-liver transplantation  Academic Article
• Effect of oxysterols on hematopoietic progenitor cells  Academic Article
• Effects of viral inhibitors of apoptosis in models of mammalian cell death.  Academic Article
• Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux  Academic Article
• Enantioselective Synthesis of Ferrocenyl Nucleoside Analogues with Apoptosis-Inducing Activity  Academic Article
• Endogenous bcl-2 is not required for the development of Eμ-myc–induced B-cell lymphoma  Academic Article
• Endothelial cell apoptosis and the role of endothelial cell-derived extracellular vesicles in the progression of atherosclerosis  Academic Article
• Enhancement of anticancer activity by silibinin and paclitaxel combination on the ovarian cancer  Academic Article
• Entamoeba histolytica: Target Cells Killed by Trophozoites Undergo DNA Fragmentation Which Is Not Blocked by Bcl-2  Academic Article
• EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation  Academic Article
• Essential versus accessory aspects of cell death: recommendations of the NCCD 2015  Academic Article
• Establishment of primary cultures of rat olfactory bulb under serum-free conditions for studies of cellular injury  Academic Article
• Evidence for a detrimental role of TLR8 in ischemic stroke  Academic Article
• Evidence of the TNF-α system in the human achilles tendon: Expression of TNF-α and TNF receptor at both protein and mRNA levels in the tenocytes  Academic Article
• Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke  Academic Article
• Evolutionary divergence of the necroptosis effector MLKL  Academic Article
• Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction  Academic Article
• Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine  Academic Article
• Exosomes: Extracellular organelles important in intercellular communication  Academic Article
• Expanded Granulocyte/Monocyte Compartment in Myeloid-Specific Triple FoxO Knockout Increases Oxidative Stress and Accelerates Atherosclerosis in Mice  Academic Article
• Experimental in vivo sepsis models to monitor immune cell apoptosis and survival in laboratory mice  Chapter
• Expression of candidate cell death genes in cell lines during apoptosis  Academic Article
• Expression of secreted frizzled-related protein 4 in the primate placenta  Academic Article
• Extracellular HtrA2 induces apoptosis in human umbilical vein endothelial cells  Academic Article
• Extracellular wildtype and mutant SOD1 induces ER–Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells  Academic Article
• FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis.  Academic Article
• Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim  Academic Article
• Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death  Academic Article
• Focus on extracellular vesicles: introducing the next small big thing  Academic Article
• Fold up or perish: unfolded protein response and chemotherapy  Academic Article
• Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species  Academic Article
• Function of microRNA-143 in different signal pathways in cancer: New insights into cancer therapy  Academic Article
• Functional and biochemical characterization of the baculovirus caspase inhibitor MaviP35  Academic Article
• Functional regulation of the plasma protein histidine-rich glycoprotein by ZN2+ in settings of tissue injury  Academic Article
• Further Insights into the Effects of Pre-organizing the BimBH3 Helix [Addendum ]  Erratum
• Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke  Academic Article
• Gasdermin E Does Not Limit Apoptotic Cell Disassembly by Promoting Early Onset of Secondary Necrosis in Jurkat T Cells and THP-1 Monocytes  Academic Article
• Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis  Academic Article
• Gold and Silver Nanoparticles Biomimetically Synthesized Using Date Palm Pollen Extract-Induce Apoptosis and Regulate p53 and Bcl-2 Expression in Human Breast Adenocarcinoma Cells  Academic Article
• Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation  Academic Article
• Granzyme M Mediates a Novel Form of Perforin-dependent Cell Death  Academic Article
• Group A Streptococcus Modulates Host Inflammation by Manipulating Polymorphonuclear Leukocyte Cell Death Responses  Academic Article
• Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor  Academic Article
• Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes  Academic Article
• HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses  Academic Article
• HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21  Academic Article
• HDACs and HDAC inhibitors in colon cancer  Academic Article
• HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death  Academic Article
• HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death  Academic Article
• Heat Shock Protein 72 Modulates Pathways of Stress-induced Apoptosis  Academic Article
• Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis  Academic Article
• Hepatitis C-induced hepatocyte apoptosis following liver transplantation is enhanced by immunosuppressive agents  Academic Article
• Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM  Academic Article
• Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction  Academic Article
• High strain mechanical loading rapidly induces tendon apoptosis: an ex vivo rat tibialis anterior model  Academic Article
• High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer  Academic Article
• Histidine-rich Glycoprotein Specifically Binds to Necrotic Cells via Its Amino-terminal Domain and Facilitates Necrotic Cell Phagocytosis  Academic Article
• Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer  Academic Article
• Hoxb8 regulates expression of microRNAs to control cell death and differentiation  Academic Article
• Hsp70 Architecture: The Formation of Novel Polymeric Structures of Hsp70.1 and Hsc70 after Proteotoxic Stress  Academic Article
• Hsp72 Inhibits Apoptosis Upstream of the Mitochondria and Not through Interactions with Apaf-1  Academic Article
• Hsp72 Inhibits Fas-mediated Apoptosis Upstream of the Mitochondria in Type II Cells  Academic Article
• Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis  Academic Article
• HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins  Academic Article
• HtrA2/Omi, a Sheep in Wolf's Clothing  Academic Article
• Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1  Academic Article
• Human beta-defensin 3 contains an oncolytic motif that binds PI(4,5)P-2 to mediate tumour cell permeabilisation  Academic Article
• Human telomerase reverse transcriptase protects hematopoietic progenitor TF-1 cells from death and quiescence induced by cytokine withdrawal  Academic Article
• Human, insect and nematode caspases kill Saccharomyces cerevisiae independently of YCA1 and Aif1p  Academic Article
• Hurpin Is a Selective Inhibitor of Lysosomal Cathepsin L and Protects Keratinocytes from Ultraviolet-Induced Apoptosis†  Academic Article
• Hypoxia Enhances the Proliferative Response of Macrophages to CSF-1 and Their Pro-Survival Response to TNF  Academic Article
• IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis  Academic Article
• IAP Family of Cell Death and Signaling Regulators  Chapter
• IAPS and ubiquitylation  Academic Article
• IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis  Academic Article
• IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3  Academic Article
• IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos  Academic Article
• Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins  Academic Article
• Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies  Academic Article
• Immunopathology of apoptosis ?introduction and overview  Academic Article
• Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice  Academic Article
• In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling  Academic Article
• In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it  Academic Article
• In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose  Academic Article
• In vitro and in vivo evaluation of the influence of type III NaPi co-transporter activity during apoptosis on 99mTc-(V)DMSA uptake in the human leukaemic cell line U937  Academic Article
• Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury  Academic Article
• Induction of apoptosis by plant natriuretic peptides in rat cardiomyoblasts  Academic Article
• Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism  Academic Article
• Inflammation and depression: Why poststroke depression may be the norm and not the exception  Academic Article
• Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor  Academic Article
• Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells  Academic Article
• Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors  Academic Article
• Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin  Academic Article
• Inhibition of interleukin 1 -converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP  Conference Paper
• Inhibition of osteoblast apoptosis by thrombin  Academic Article
• Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation  Academic Article
• Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation  Academic Article
• Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy  Academic Article
• Inhibitor of apoptosis protein-1 regulates tumor necrosis factor-mediated destruction of intestinal epithelial cells  Academic Article
• Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs  Academic Article
• Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells  Academic Article
• Insights from Bcl-2 and Myc: Malignancy Involves Abrogation of Apoptosis as well as Sustained Proliferation  Conference Paper
• Integral membrane protease fibroblast activation protein sensitizes fibrosarcoma to chemotherapy and alters cell death mechanisms  Academic Article
• Integration of Biologic Agents With Cytotoxic Chemotherapy in Metastatic Colorectal Cancer  Academic Article
• Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1  Academic Article
• Interleukin-11 links oxidative stress and compensatory proliferation  Academic Article
• Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice  Academic Article
• Interplay between Notch and p53 promotes neuronal cell death in ischemic stroke  Academic Article
• Interruption of classic CD40L-CD40 signalling but not of the novel CD40L-Mac-1 interaction limits arterial neointima formation in mice  Academic Article
• Intravenous immunoglobulin (IVIg) dampens neuronal toll-like receptor-mediated responses in ischemia  Academic Article
• Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion  Academic Article
• Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis  Academic Article
• Isolation of cardiomyocytes and cardiofibroblasts for ex vivo analysis  Chapter
• Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting  Academic Article
• Jekyll and Hyde: The other life of the death ligand TRAIL  Comment
• Jekyll and Hyde; changing places, changing faces  Academic Article
• Kainate-induced apoptosis correlates with c-Jun activation in cultured cerebellar granule cells  Academic Article
• Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins  Academic Article
• L1cam acts as a modifier gene for members of the endothelin signalling pathway during enteric nervous system development  Academic Article
• LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice  Academic Article
• Lgl, the SWH pathway and tumorigenesis: It’s a matter of context and competition!  Academic Article
• Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands  Academic Article
• Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer  Academic Article
• Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice  Academic Article
• Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells  Academic Article
• Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor  Academic Article
• M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe  Academic Article
• MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication  Academic Article
• MK2 phosphorylates RIPK1 to prevent TNF-induced cell death  Academic Article
• MYB80 homologues in Arabidopsis, cotton and Brassica: regulation and functional conservation in tapetal and pollen development  Academic Article
• Making Sense of HDAC2 Mutations in Colon Cancer  Academic Article
• Mammalian initiator apoptotic caspases  Academic Article
• Mammalian mitochondrial IAP binding proteins  Academic Article
• Manipulating Eryptosis of Human Red Blood Cells: a Novel Antimalarial Strategy?  Academic Article
• Matrix metalloproteinase-2 is involved in the migration and network formation of enteric neural crest-derived cells  Academic Article
• Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells  Academic Article
• Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets  Academic Article
• Membrane-bound Fas ligand only is essential for Fas-induced apoptosis  Academic Article
• Menadione (Vitamin K3) Induces Apoptosis of Human Oral Cancer Cells and Reduces their Metastatic Potential by Modulating the Expression of Epithelial to Mesenchymal Transition Markers and Inhibiting Migration  Academic Article
• Methods for studying TNF-mediated necroptosis in cultured cells  Chapter
• Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways  Academic Article
• Mitochondria-Targeted Chemotherapeutics: The Rational Design of Gold(I)N-Heterocyclic Carbene Complexes That Are Selectively Toxic to Cancer Cells and Target Protein Selenols in Preference to Thiols  Academic Article
• Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming  Academic Article
• Mitochondrial morphology and distribution in mammalian cells  Academic Article
• Mitoxantrone Mediates Demethylation and Re-Expression of Cyclin D2, Estrogen Receptor 14.3.3 Sigma In Breast Cancer Cells  Academic Article
• Modeling Biological Activities of Nanoparticles  Academic Article
• Modeling metazoan apoptotic pathways in yeast  Chapter
• Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes  Academic Article
• Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis  Academic Article
• Modulation of Cellular Hsp72 Levels in Undifferentiated and Neuron-Like SH-SY5Y Cells Determines Resistance to Staurosporine-Induced Apoptosis  Academic Article
• Modulation of the Multidrug Resistance of Glioma by Glutathione Levels Depletion - Interaction with TC-99M-Sestamibi and TC-99M-Tetrofosmin  Academic Article
• Modulator of apoptosis-1 is a potential therapeutic target in acute ischemic injury  Academic Article
• Molecular Mechanisms of Apoptosis: An Overview  Academic Article
• Molecular and clinical aspects of apoptosis  Academic Article
• Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells  Academic Article
• Molecular mechanisms of late apoptotic/necrotic cell clearance  Academic Article
• Monitoring Activity of Caspases and Their Regulators in Yeast Saccharomyces cerevisiae  Book
• Motor neurone disease and the life of motor neurones  Academic Article
• Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis  Academic Article
• Multifaceted deaths orchestrated by mitochondria in neurones  Academic Article
• Multifaceted effects of ATP on cardiolipin-bound cytochrome c  Academic Article
• Multiple Autocrine Factors Including an Extracellular Matrix Protein are Required for the Proliferation and Spreading of Human Colon Carcinoma CellsIn Vitro  Academic Article
• Mutation to bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis  Academic Article
• NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival  Academic Article
• NF-κB Inhibition Reveals Differential Mechanisms of TNF Versus TRAIL-Induced Apoptosis Upstream or at the Level of Caspase-8 Activation Independent of cIAP2  Academic Article
• Necroptosis induced by RIPK3 requires MLKL but not Drp1  Academic Article
• Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted  Academic Article
• Nedd4-WW Domain-Binding Protein 5 (Ndfip1) Is Associated with Neuronal Survival after Acute Cortical Brain Injury  Academic Article
• Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2.  Academic Article
• NetPath: a public resource of curated signal transduction pathways  Academic Article
• Neuronal low-density lipoprotein receptor-related protein 1 (LRP1) enhances the anti-apoptotic effect of intravenous immunoglobulin (IVIg) in ischemic stroke  Academic Article
• Neuronal oxidative stress in acute ischemic stroke: sources and contribution to cell injury  Academic Article
• Normoxic regulation of HIF-1α in prostate cancer  Letter
• Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan  Academic Article
• Ontogenetic Changes in Retinal Ganglion Cell Distribution and Spatial Resolving Power in the Brown-Banded Bamboo Shark Chiloscyllium punctatum (Elasmobranchii)  Academic Article
• Over-Expression of DSCR1 Protects against Post-Ischemic Neuronal Injury  Academic Article
• Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis  Academic Article
• Overexpression of Endogenous Anti-Oxidants with Selenium Supplementation Protects Trophoblast Cells from Reactive Oxygen Species-Induced Apoptosis in a Bcl-2-Dependent Manner  Academic Article
• Overexpression of insulin-like growth factor binding protein-6 inhibits rhabdomyosarcoma growthin vivo  Academic Article
• PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF  Academic Article
• PSGL-1-Mediated Adhesion of Human Hematopoietic Progenitors to P-Selectin Results in Suppression of Hematopoiesis  Academic Article
• Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack  Academic Article
• Phosphoinositides: Multipurpose cellular lipids with emerging roles in cell death  Academic Article
• Physiological restraint of Bak by Bcl-x(L) is essential for cell survival  Academic Article
• Pin1 promotes neuronal death in stroke by stabilizing notch intracellular domain  Academic Article
• Plexin B2 is a regulator of monocyte apoptotic cell disassembly  Academic Article
• Plumbagin Downregulates Wnt Signaling Independent of p53 in Human Colorectal Cancer Cells  Academic Article
• Postchemotherapy and Tumor-Selective Targeting with the La-Specific DAB4 Monoclonal Antibody Relates to Apoptotic Cell Clearance  Academic Article
• Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2  Academic Article
• Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation  Academic Article
• Programmed Anuclear Cell Death Delimits Platelet Life Span  Academic Article
• Programmed cell death: Superman meets Dr Death  Conference Paper
• Progranulin does not inhibit TNF and lymphotoxin-signalling through TNF receptor 1  Academic Article
• Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak  Academic Article
• Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells  Academic Article
• Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts  Academic Article
• Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent  Academic Article
• Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes  Academic Article
• Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim  Academic Article
• Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity  Academic Article
• RIP-in CD95-induced cell death: The control of alternative death receptors pathways by cIAPs  Academic Article
• RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation  Academic Article
• RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development  Academic Article
• RIPK1-and RIPK3-induced cell death mode is determined by target availability  Academic Article
• RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL  Academic Article
• Radiation Response of Mouse Lymphoid and Myeloid Cell Lines. Part II. Apoptotic Death is Shown by all Lines Examined  Academic Article
• Radioimmunotherapy with  -Particle-Emitting 213Bi-C-Functionalized trans-Cyclohexyl-Diethylenetriaminepentaacetic Acid-Humanized 3S193 Is Enhanced by Combination with Paclitaxel Chemotherapy  Conference Paper
• Radiosensitizing activity of a novel Benzoxazine through the promotion of apoptosis and inhibition of DNA repair  Academic Article
• Reactive Oxygen Species and Their Contribution to Pathology in Down Syndrome  Academic Article
• Recent Advances in Understanding and Exploiting the Activation of Anthracyclines by Formaldehyde  Academic Article
• Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations  Academic Article
• Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction  Academic Article
• Regulation of Enterocyte Apoptosis by Acyl-CoA Synthetase 5 Splicing  Academic Article
• Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs  Academic Article
• Repurposing apoptosis-inducing cancer drugs to treat schistosomiasis  Academic Article
• Requirements for proteolysis during apoptosis.  Academic Article
• Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics  Academic Article
• Resistance to butyrate-induced cell differentiation and apoptosis during spontaneous Caco-2 cell differentiation  Academic Article
• Response of a primary human fibroblast cell line to H2O2: Senescence- like growth arrest or apoptosis?  Academic Article
• Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP  Academic Article
• Role of a novel benzoxazine derivative in the chemosensitization of colon cancer  Academic Article
• Role of p53 in cAMP/PKA pathway mediated apoptosis  Academic Article
• Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats  Academic Article
• SIRT2 inhibition confers neuroprotection by downregulation of FOXO3a and MAPK signaling pathways in ischemic stroke  Academic Article
• STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2  Academic Article
• Scribble acts as an oncogene in Em-myc-driven lymphoma  Academic Article
• Selective inhibition of endogenous antioxidants with Auranofin causes mitochondrial oxidative stress which can be countered by selenium supplementation  Academic Article
• Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?  Academic Article
• Sex-Dependent Effects of G Protein-Coupled Estrogen Receptor Activity on Outcome After Ischemic Stroke  Academic Article
• SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda  Academic Article
• Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins  Academic Article
• Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission  Academic Article
• Signalling by CD95 and TNF receptors: Not only life and death  Academic Article
• Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization  Academic Article
• Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice  Academic Article
• Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat  Academic Article
• Spectrum of Radiopharmaceuticals in Nuclear Oncology  Academic Article
• Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity  Academic Article
• Stress proteins and apoptosis in prenatal development, cancer and medicine  Academic Article
• Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1  Academic Article
• Structural and functional insight into canarypox virus CNP058 mediated regulation of apoptosis  Academic Article
• Structural basis of Deerpox virus-mediated inhibition of apoptosis  Academic Article
• Structural biology of the Bcl-2 family and its mimicry by viral proteins  Academic Article
• Structural insight into African swine fever virus A179L-mediated inhibition of apoptosis  Academic Article
• Structural insight into an evolutionarily ancient programmed cell death regulator – the crystal structure of marine sponge BHP2 bound to LB-Bak-2  Academic Article
• Structural insights into the degradation of Mcl-1 induced by BH3 domains  Academic Article
• Structure-guided design of a selective BCL-XL inhibitor  Academic Article
• Sublethal Concentrations of Prion Peptide PrP106–126 or the Amyloid Beta Peptide of Alzheimer's Disease Activates Expression of Proapoptotic Markers in Primary Cortical Neurons  Academic Article
• Subversion of the Bcl-2 Life/Death Switch in Cancer Development and Therapy  Conference Paper
• Sulindac activates NF-κB signaling in colon cancer cells  Academic Article
• Sulindac modulates secreted protein expression from LIM1215 colon carcinoma cells prior to apoptosis  Academic Article
• TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1  Academic Article
• TOLL-LIKE RECEPTORS IN ISCHEMIA-REPERFUSION INJURY  Academic Article
• TR3/Nur77 in colon cancer cell apoptosis  Academic Article
• TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis  Academic Article
• TRAF2 regulates TNF and NF-kappa B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1  Academic Article
• TRAIL and Malignant Glioma  Academic Article
• TRAIL in cancer therapy: present and future challenges  Academic Article
• TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT  Academic Article
• TRAIL-induced apoptosis is enhanced by heat shock protein 70 expression  Academic Article
• Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer  Academic Article
• Targeting EphA3 inhibits cancer growth by disrupting the tumor stromal microenvironment  Academic Article
• Targeting XIAP and PPARγ in granulosa cell tumors alters metabolic signaling  Academic Article
• Targeting neuropilin-1 in human leukemia and lymphoma  Academic Article
• Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice  Academic Article
• Tenocyte responses to mechanical loading in vivo - A role for local insulin-like growth factor 1 signaling in early tendinosis in rats  Academic Article
• Tenocyte responses to mechanical loading in vivo: A role for local insulin-like growth factor 1 signaling in early tendinosis in rats  Academic Article
• The BECN1 N-terminal domain is intrinsically disordered  Academic Article
• The Bcl-2 family in autoimmune and degenerative disorders  Academic Article
• The Bcl-2 family in host-virus interactions  Academic Article
• The Bcl-2 family: structures, interactions and targets for drug discovery  Academic Article
• The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast  Academic Article
• The Carboxyl-Terminal Domain of Inducible Hsp70 Protects from Ischemic Injuryin vivoandin vitro  Academic Article
• The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID  Academic Article
• The Drosophila caspase DRONC is a glutamate/aspartate protease whose activity is regulated by DIAP1, HID and GRIM  Academic Article
• The Drosophila caspase DRONC is regulated by DIAP1  Academic Article
• The FLIP side of life  Academic Article
• The Homocysteine-inducible Endoplasmic Reticulum Stress Protein Counteracts Calcium Store Depletion and Induction of CCAAT Enhancer-binding Protein Homologous Protein in a Neurotoxin Model of Parkinson Disease  Academic Article
• The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation  Academic Article
• The N Terminus of the Vaccinia Virus Protein F1L Is an Intrinsically Unstructured Region That Is Not Involved in Apoptosis Regulation  Academic Article
• The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex  Academic Article
• The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis  Academic Article
• The Receptor Tyrosine Kinase EPHB4 Has Tumor Suppressor Activities in Intestinal Tumorigenesis  Academic Article
• The Role of Bim, a Proapoptotic BH3-Only Member of the Bcl-2 Family, in Cell-Death Control  Conference Paper
• The Role of Protease-Activated Receptor-1 in Bone Healing  Academic Article
• The Role of the Pro-Apoptotic Bcl-2 Family Member Bim in Physiological Cell Death  Conference Paper
• The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster  Academic Article
• The Structural Biology of BH3-Only Proteins  Academic Article
• The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3– and caspase 9–interacting sites  Academic Article
• The apoptosis pathway and the genetic predisposition to Achilles tendinopathy  Academic Article
• The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis  Academic Article
• The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity  Academic Article
• The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia  Academic Article
• The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling  Academic Article
• The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains  Academic Article
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• The importance of being chaperoned: HSP90 and necroptosis  Editorial Article
• The induction and consequences of Influenza A virus-induced cell death.  Academic Article
• The intersection of cell death and inflammasome activation  Academic Article
• The medical significance of physiological cell death  Academic Article
• The mitochondria-targeting peptide elamipretide diminishes circulating HtrA2 in ST-segment elevation myocardial infarction  Academic Article
• The mitochondrial death squad: hardened killers or innocent bystanders?  Academic Article
• The molecular biology of apoptosis.  Academic Article
• The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis  Academic Article
• The polycomb repressive complex 2 governs life and death of peripheral T cells  Academic Article
• The proto-oncogene Ret is required for male foetal germ cell survival  Academic Article
• The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism  Academic Article
• The regulation of TNF signalling: What a tangled web we weave  Academic Article
• The regulation of mitochondrial morphology: Intricate mechanisms and dynamic machinery  Academic Article
• The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist  Academic Article
• The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins  Academic Article
• The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system  Academic Article
• The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy  Academic Article
• The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes  Academic Article
• Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant–dependent lung carcinomas  Academic Article
• Therapeutic efficacy of177Lu-CHX-A″-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy  Academic Article
• Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice  Academic Article
• Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies  Academic Article
• Till Death Do Us Part  Academic Article
• To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions  Academic Article
• Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal  Academic Article
• Toward an understanding of the molecular mechanisms of physiological cell death.  Academic Article
• Transduction of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand into Hematopoietic Cells Leads to Inhibition of Syngeneic Tumor Growth In vivo  Academic Article
• Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins  Academic Article
• Tumor Cell Response to Synchrotron Microbeam Radiation Therapy Differs Markedly From Cells in Normal Tissues  Academic Article
• Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding  Academic Article
• Tumor-specific nuclear targeting: Promises for anti-cancer therapy?  Academic Article
• Two kinds of BIR-containing protein - Inhibitors of apoptosis, or required for mitosis  Academic Article
• Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2  Academic Article
• Unexpected link between an antibiotic, pannexin channels and apoptosis  Academic Article
• Unlike Diablo/smac, Grim Promotes Global Ubiquitination and Specific Degradation of X Chromosome-linked Inhibitor of Apoptosis (XIAP) and Neither Cause Apoptosis  Academic Article
• Uteroplacental insufficiency in rats induces renal apoptosis and delays nephrogenesis completion  Academic Article
• Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands  Academic Article
• Vaccinia virus encodes a novel inhibitor of apoptosis that associates with the apoptosome  Academic Article
• Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim  Academic Article
• Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation  Academic Article
• Viewing BCL2 and cell death control from an evolutionary perspective  Academic Article
• Viral Infection and Apoptosis  Editorial Article
• Viral Inhibitors of Apoptosis  Academic Article
• Viral, worm and radical implications for apoptosis  Academic Article
• What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain  Academic Article
• What you eat is what you are - A role for polyunsaturated fatty acids in neuroinflammation induced depression?  Academic Article
• XIAP discriminates between type I and type II FAS-induced apoptosis  Academic Article
• XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland  Academic Article
• Yeast techniques for modeling drugs targeting Bcl-2 and caspase family members  Academic Article
• [6]-gingerol as a cancer chemopreventive agent: A review of its activity on different steps of the metastatic process  Academic Article
• c-Myb is critical for murine colon development  Academic Article
• c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis  Academic Article
• c-myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression  Academic Article
• cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner  Academic Article
• gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis  Academic Article
• scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila  Academic Article
• scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs  Academic Article
• β-Catenin/Tcf-4 Inhibition After Progastrin Targeting Reduces Growth and Drives Differentiation of Intestinal Tumors  Academic Article