subject area of
- A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak Academic Article
- A model for studying the hemostatic consumption or destruction of platelets Academic Article
- Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak Academic Article
- Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane Academic Article
- BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis Academic Article
- BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux Academic Article
- BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy Academic Article
- BH3-only proteins: a 20-year stock-take Academic Article
- Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains Academic Article
- Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function Academic Article
- Bcl-2 family proteins: The sentinels of the mitochondrial apoptosis pathway Academic Article
-
Bcl-2, Bcl-x
L , and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells Academic Article - Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax Academic Article
- Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199 Academic Article
- Controlling TRAIL-mediated caspase-3 activation Academic Article
- Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design Academic Article
- Cycloheximide can induce Bax/Bak dependent myeloid cell death independently of multiple BH3-only proteins Academic Article
- Deerpox Virus Encodes an Inhibitor of Apoptosis That Regulates Bak and Bax Academic Article
- Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL Academic Article
- Hoxb8 regulates expression of microRNAs to control cell death and differentiation Academic Article
- Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies Academic Article
- Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor Academic Article
- Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins Academic Article
- MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication Academic Article
- Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins Academic Article
- Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis Academic Article
- Physiological restraint of Bak by Bcl-x(L) is essential for cell survival Academic Article
- Platelet senescence is regulated by an internal timer, not damage inflicted by hits Academic Article
- Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak Academic Article
- Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins Academic Article
- Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L Academic Article
- Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer Academic Article
- TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1 Academic Article
- To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions Academic Article
- Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins Academic Article
- Vaccinia Virus F1L Interacts with Bak Using Highly Divergent Bcl-2 Homology Domains and Replaces the Function of Mcl-1 Academic Article