subject area of

• A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak  Academic Article
• A model for studying the hemostatic consumption or destruction of platelets  Academic Article
• Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak  Academic Article
• Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane  Academic Article
• BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis  Academic Article
• BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux  Academic Article
• BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy  Academic Article
• BH3-only proteins: a 20-year stock-take  Academic Article
• Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains  Academic Article
• Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function  Academic Article
• Bcl-2 family proteins: The sentinels of the mitochondrial apoptosis pathway  Academic Article
• Bcl-2, Bcl-x L, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells  Academic Article
• Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax  Academic Article
• Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199  Academic Article
• Controlling TRAIL-mediated caspase-3 activation  Academic Article
• Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design  Academic Article
• Cycloheximide can induce Bax/Bak dependent myeloid cell death independently of multiple BH3-only proteins  Academic Article
• Deerpox Virus Encodes an Inhibitor of Apoptosis That Regulates Bak and Bax  Academic Article
• Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL  Academic Article
• Hoxb8 regulates expression of microRNAs to control cell death and differentiation  Academic Article
• Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies  Academic Article
• Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor  Academic Article
• Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins  Academic Article
• MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication  Academic Article
• Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins  Academic Article
• Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis  Academic Article
• Physiological restraint of Bak by Bcl-x(L) is essential for cell survival  Academic Article
• Platelet senescence is regulated by an internal timer, not damage inflicted by hits  Academic Article
• Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak  Academic Article
• Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins  Academic Article
• Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L  Academic Article
• Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer  Academic Article
• TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1  Academic Article
• To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions  Academic Article
• Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins  Academic Article
• Vaccinia Virus F1L Interacts with Bak Using Highly Divergent Bcl-2 Homology Domains and Replaces the Function of Mcl-1  Academic Article