bcl-X Protein
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(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xLRecognition: Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions Academic Article
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A model for studying the hemostatic consumption or destruction of platelets Academic Article
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ATF3 Repression of BCL-X L Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types Academic Article
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Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells Academic Article
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Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma Academic Article
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Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak Academic Article
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BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines Academic Article
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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes Academic Article
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Bcl-2, Bcl-x L, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells Academic Article
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Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax Academic Article
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Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment Academic Article
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Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin Academic Article
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Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands Academic Article
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Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family Academic Article
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De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization Academic Article
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Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function Academic Article
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Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL Academic Article
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Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition Academic Article
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EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency Academic Article
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Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain Academic Article
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Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor Academic Article
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Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM Academic Article
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High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL Academic Article
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Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins Academic Article
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Physiological restraint of Bak by Bcl-x(L) is essential for cell survival Academic Article
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Platelet senescence is regulated by an internal timer, not damage inflicted by hits Academic Article
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Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation Academic Article
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Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells Academic Article
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Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity Academic Article
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Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics Academic Article
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Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design Academic Article
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Structure-guided design of a selective BCL-XL inhibitor Academic Article
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Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer Academic Article
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The BECN1 N-terminal domain is intrinsically disordered Academic Article
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The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia Academic Article
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The Structural Biology of Bcl-xL Academic Article
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The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains Academic Article
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The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system Academic Article
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Yeast techniques for modeling drugs targeting Bcl-2 and caspase family members Academic Article