subject area of

• (α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xLRecognition:  Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions  Academic Article
• A model for studying the hemostatic consumption or destruction of platelets  Academic Article
• ATF3 Repression of BCL-X L Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types  Academic Article
• Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells  Academic Article
• Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma  Academic Article
• Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak  Academic Article
• BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines  Academic Article
• BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes  Academic Article
• Bcl-2, Bcl-x L, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells  Academic Article
• Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax  Academic Article
• Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment  Academic Article
• Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin  Academic Article
• Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands  Academic Article
• Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family  Academic Article
• De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization  Academic Article
• Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function  Academic Article
• Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL  Academic Article
• Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition  Academic Article
• EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency  Academic Article
• Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain  Academic Article
• Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor  Academic Article
• Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM  Academic Article
• High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL  Academic Article
• Physiological restraint of Bak by Bcl-x(L) is essential for cell survival  Academic Article
• Platelet senescence is regulated by an internal timer, not damage inflicted by hits  Academic Article
• Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation  Academic Article
• Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells  Academic Article
• Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity  Academic Article
• Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics  Academic Article
• Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design  Academic Article
• Structure-guided design of a selective BCL-XL inhibitor  Academic Article
• Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer  Academic Article
• The BECN1 N-terminal domain is intrinsically disordered  Academic Article
• The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia  Academic Article
• The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains  Academic Article
• The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system  Academic Article
• Yeast techniques for modeling drugs targeting Bcl-2 and caspase family members  Academic Article