subject area of

• 3-Phosphonopropionic acids inhibit carboxypeptidase A as multisubstrate analogues or transition-state analogues  Academic Article
• A Biophysical Analysis of the Tetratricopeptide Repeat-rich Mitochondrial Import Receptor, Tom70, Reveals an Elongated Monomer That Is Inherently Flexible, Unstable, and Unfolds via a Multistate Pathway  Academic Article
• A Family of Leukemia Inhibitory Factor-Binding Peptides that Can Act as Antagonists When Conjugated to Poly(ethylene glycol)†  Academic Article
• A Membrane-Bound NAC Transcription Factor, ANAC017, Mediates Mitochondrial Retrograde Signaling in Arabidopsis  Academic Article
• A Molecular Understanding of Mitoxantrone-DNA Adduct Formation  Academic Article
• A Possible Role for Metallic Ions in the Carbohydrate Cluster Recognition Displayed by a Lewis Y Specific Antibody  Academic Article
• A Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation  Academic Article
• A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor  Academic Article
• A comparative study between the adsorption and covalent binding of human immunoglobulin and lysozyme on surface-modified poly(tert-butyl methacrylate)  Academic Article
• A conserved energetic footprint underpins recognition of Human Leukocyte Antigen-E by two distinct αβ T cell receptors  Academic Article
• A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI  Academic Article
• A labile repressor acts through the NFkB-like binding sites of the human urokinase gene  Academic Article
• A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense  Academic Article
• A molecular approach in drug development for Alzheimer’s disease  Academic Article
• A molecular intravascular ultrasound contrast agent allows detection of activated platelets on the surface of symptomatic human plaques  Academic Article
• A naturally occurring NAR variable domain binds the Kgp protease fromPorphyromonas gingivalis  Academic Article
• A novel role for the pol I transcription factor ubtf in maintaining genome stability through the regulation of highly transcribed pol II genes  Academic Article
• A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein  Academic Article
• A serine/arginine-rich nuclear matrix cyclophilin interacts with the C- terminal domain of RNA polymerase II  Academic Article
• A steered molecular dynamics mediated hit discovery for histone deacetylases  Academic Article
• AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP  Academic Article
• AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells  Academic Article
• Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice  Academic Article
• Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death  Academic Article
• Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme  Academic Article
• Activity and DNA binding of new organoamidoplatinum (II) complexes  Academic Article
• Adriamycin-induced DNA Adducts Inhibit the DNA Interactions of Transcription Factors and RNA Polymerase  Academic Article
• Affinity Maturation of Leukemia Inhibitory Factor and Conversion to Potent Antagonists of Signaling  Academic Article
• An Immune Response Directed to Proteinase and Adhesin Functional Epitopes Protects against Porphyromonas gingivalis-Induced Periodontal Bone Loss  Academic Article
• An In Vitro Transcription Assay for Probing Drug-DNA Interactions During Active Transcription of DNA  Academic Article
• An Oligonucleotide Crosslinking Assay for the Analysis of Individual Drug-Binding Sites  Chapter
• An alternative oxidase monoclonal antibody recognises a highly conserved sequence among alternative oxidase subunits  Academic Article
• An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke  Academic Article
• An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals  Academic Article
• An approach towards molecular imaging of activated platelets allows imaging of symptomatic human carotid plaques in a new model of a tissue flow chamber  Academic Article
• An orthorhombic form ofEscherichia coliaminopeptidase P at 2.4 Å resolution  Academic Article
• Analysis of Agaricus meleagris pyranose dehydrogenase N-glycosylation sites and performance of partially non-glycosylated enzymes  Academic Article
• Analysis of Grb7 Recruitment by Heregulin-activated erbB Receptors Reveals a Novel Target Selectivity for erbB3  Academic Article
• Analysis of inhibitor binding in influenza virus neuraminidase  Academic Article
• Analysis of structure and function of the giant protein Pf332 inPlasmodium falciparum  Academic Article
• Analysis of the Regulation of the A33 Antigen Gene Reveals Intestine-specific Mechanisms of Gene Expression  Academic Article
• Analysis of the minimal specificity of CED-3 using a yeast transcriptional reporter system  Academic Article
• Apical Membrane Antigen 1 as an Anti-Malarial Drug Target  Academic Article
• Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction  Academic Article
• Architecture of Eph receptor clusters  Academic Article
• Artificial Neural Network (ANN) Based Modelling for D1 Like and D2 Like Dopamine Receptor Affinity and Selectivity  Academic Article
• Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS  Academic Article
• Auxin-binding-protein antibodies and peptides influence stomatal opening and alter cytoplasmic pH  Academic Article
• BLOCKING OF DELIVERY OF THE ANTIGEN-MEDIATED SIGNAL TO THE NUCLEUS OF T CELLS BY CYCLOSPORINS  Academic Article
• Binding Inhibitors of the Bacterial Sliding Clamp by Design  Academic Article
• Binding energetics of phosphorus-containing inhibitors of thermolysin  Academic Article
• Binding of pixantrone to DNA at CpA dinucleotide sequences and bulge structures  Academic Article
• Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1  Academic Article
• Biochemical, autoradiographic and functional studies on a unique glutamate binding site in adrenal gland  Academic Article
• Biochemistry and molecular biology of exocellular fungal β-(1,3)- and β-(1,6)-glucanases  Academic Article
• C4bp binding to porin mediates stable serum resistance of Neisseria gonorrhoeae  Conference Paper
• CD1d-lipid antigen recognition by the γδ TCR.  Academic Article
• CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence  Academic Article
• Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function  Academic Article
• Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling  Academic Article
• Can metal ions be used as gas-phase disulfide bond cleavage reagents? A survey of coinage metal complexes of model peptides containing an intermolecular disulfide bond  Academic Article
• Can thioglycosides imitate the oxonium intermediate in glycosyl hydrolases?  Academic Article
• Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions  Academic Article
• Carbene footprinting reveals binding interfaces of a multimeric membrane-spanning protein  Academic Article
• Caspase Proteolysis of the Cohesin Component RAD21 Promotes Apoptosis  Academic Article
• Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH  Academic Article
• Characteristics of the core protein of the aggregating proteoglycan from the Swarm rat chondrosarcoma  Academic Article
• Characterization of FcR Ig-Binding Sites and Epitope Mapping  Academic Article
• Characterization of Two Protein Disulfide Isomerases from the Endocytic Pathway of Bloodstream Forms of Trypanosoma brucei  Academic Article
• Characterization of rat brain stathmin isoforms by two-dimensional gel electrophoresis-matrix assisted laser desorption/ionization and electrospray ionizationion trap mass spectrometry  Academic Article
• Characterization of the Specificity of Arginine-Specific Gingipains fromPorphyromonas gingivalisReveals Active Site Differences between Different Forms of the Enzymes†  Academic Article
• Chimeric Fc receptors identify immunoglobulin-binding regions in human FcγRII and FcεRI  Academic Article
• ClpS is an essential component of the N-end rule pathway in Escherichia coli  Academic Article
• Comparative analysis of ATRX, a chromatin remodeling protein  Academic Article
• Comparative aspects of the calcium-sensitive photoproteins aequorin and obelin  Academic Article
• Competitive Inhibition Mechanism of Acetylcholinesterase without Catalytic Active Site Interaction: Study on Functionalized C60 Nanoparticles via in Vitro and in Silico Assays  Academic Article
• Complete amino acid analysis of proteins from a single hydrolysate  Academic Article
• Complex demethylation patterns at Sp1 binding sites in F9 embryonal carcinoma cells  Academic Article
• Conformational Change in the Chromatin Remodelling Protein MENT  Academic Article
• Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands  Academic Article
• Conformational changes in serpins: II. the mechanism of activation of antithrombin by heparin  Academic Article
• Contribution of Specific Disulphide Bonds to Two Epitopes of Thyrotropin beta-Subunit Associated with Receptor Recognition  Academic Article
• Controls and constrains of the membrane disrupting action of Aurein 1.2  Academic Article
• Cooperative effects in the substrate specificity of the complement protease C1s  Academic Article
• Copper and Zinc Binding Modulates the Aggregation and Neurotoxic Properties of the Prion Peptide PrP106−126†  Academic Article
• Cre-loxP-mediated recombination: General principles and experimental considerations  Academic Article
• Crystal Structure and Comparative Functional Analyses of a Mycobacterium Aldo-Keto Reductase  Academic Article
• Crystal Structure of LipL32, the Most Abundant Surface Protein of Pathogenic Leptospira spp.  Academic Article
• Crystal Structure of a Legionella pneumophila Ecto -Triphosphate Diphosphohydrolase, A Structural and Functional Homolog of the Eukaryotic NTPDases  Academic Article
• Crystal Structure of a Soluble Form of the Intracellular Chloride Ion Channel CLIC1 (NCC27) at 1.4-Å Resolution  Academic Article
• Crystal structure and immunological properties of the first annexin fromSchistosoma mansoni: insights into the structural integrity of the schistosomal tegument  Academic Article
• Crystal structure and kinetic study of dihydrodipicolinate synthase fromMycobacterium tuberculosis  Academic Article
• Crystal structure of auracyanin, a “blue” copper protein from the green thermophilic photosynthetic bacterium Chloroflexus aurantiacus11Edited by R Huber  Academic Article
• Crystal structure of fuculose aldolase from the Antarctic psychrophilic yeast Glaciozyma antarctica PI12  Academic Article
• Crystal structure of human L-xylulose reductase holoenzyme: Probing the role of Asn107 with site-directed mutagenesis  Academic Article
• Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser  Academic Article
• Crystal structure of the human leukocyte Fc receptor, FcγRIIa  Academic Article
• Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide  Academic Article
• Crystallization of a ZRANB2–RNA complex  Academic Article
• Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase 1 1Edited by R. Huber  Academic Article
• Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target  Academic Article
• Cytosine Arabinoside Influx and Nucleoside Transport Sites in Acute Leukemia  Academic Article
• Cytosine Methylation Enhances Mitoxantrone-DNA Adduct Formation at CpG Dinucleotides  Academic Article
• DNA damage by nitrogen mustard in a gene containing multiple Sp1-binding sites  Academic Article
• DNA sequence specificity of mitoxantrone  Academic Article
• Daunomycin-DNA dissociation kinetics  Academic Article
• Design of potential anti-HIV agents. 1. Mannosidase inhibitors  Academic Article
• Design, synthesis and binding properties of a fluorescent α₉β₁/α₄β₁ integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells  Academic Article
• Detection of conformational changes in rat kidney gamma-glutamyl transpeptidase by an antibody against a synthetic peptide belonging to part of the reactive centre of the enzyme  Academic Article
• Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data  Academic Article
• Differential sensitivity of transcription factors to mustard-damaged DNA  Academic Article
• Dihydroorotase from Escherichia coli: Loop Movement and Cooperativity between Subunits  Academic Article
• Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction  Academic Article
• Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine  Academic Article
• Does Adriamycin Induce Interstrand Cross-Links in DNA?  Academic Article
• Domain One of the High Affinity IgE Receptor, FcεRI, Regulates Binding to IgE through Its Interface with Domain Two  Academic Article
• Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels  Academic Article
• Drug-resistant mutants of chinese hamster ovary cells possess an altered cell surface carbohydrate component  Academic Article
• Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus  Academic Article
• Dynamic modelling reveals 'hotspots' on the pathway to enzyme-substrate complex formation  Academic Article
• E2F1 Binds to the Peptide-Binding Groove within the BIR3 Domain of cIAP1 and Requires cIAP1 for Chromatin Binding  Academic Article
• EKLF/KLF1 Controls Cell Cycle Entry via Direct Regulation of E2f2  Academic Article
• Early Growth Response Gene 1 (EGR1) Regulates Heparanase Gene Transcription in Tumor Cells  Academic Article
• EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit.  Academic Article
• Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin  Academic Article
• Effects of Mutations in the Cytoplasmic Domain of Integrin β1 to Talin Binding and Cell Spreading  Academic Article
• Electronic Structure Description of thecis-MoOS Unit in Models for Molybdenum Hydroxylases  Academic Article
• Elucidation of the Substrate Specificity of the C1s Protease of the Classical Complement Pathway  Academic Article
• Energy based pharmacophore mapping of HDAC inhibitors against class I HDAC enzymes  Academic Article
• Enzymic, Phylogenetic, and Structural Characterization of the Unusual Papain-like Protease Domain ofPlasmodium falciparumSERA5  Academic Article
• Evaluation of Different Oligonucleotide Base Substitutions at CpG Binding sites in Multiplex Bisulfite-PCR sequencing  Academic Article
• Evaluation of quantitative probes for weaker Cu(i) binding sites completes a set of four capable of detecting Cu(i) affinities from nanomolar to attomolar  Academic Article
• Evolution of Quaternary Structure in a Homotetrameric Enzyme  Academic Article
• Evolution of Serpin Specificity: Cooperative Interactions in the Reactive-Site Loop Sequence of Antithrombin Specifically Restrict the Inhibition of Activated Protein C  Academic Article
• Expansin-Like Molecules: Novel Functions Derived from Common Domains  Academic Article
• Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release  Academic Article
• Expression of stress response protein glucose regulated protein-78 mediated by c-Myb  Academic Article
• Expression of the MAGE-1 gene in human hepatocellular carcinomas  Academic Article
• Filamin repeat segments required for photosensory signalling in Dictyostelium discoideum  Academic Article
• Fine Specificity of Plasmodium vivax Duffy Binding Protein Binding Engagement of the Duffy Antigen on Human Erythrocytes  Academic Article
• Fine Structure Analysis of Interaction of FcεRI with IgE  Academic Article
• Fluorescent Bioprobes: Structural Matching in the Docking Processes of Aggregation-Induced Emission Fluorogens on DNA Surfaces  Academic Article
• For the record: A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica  Academic Article
• Functional implications of modifying RyR-activating peptides for membrane permeability  Academic Article
• GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop  Academic Article
• Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130  Academic Article
• Gel chromatographic procedure that corrects for Donnan effects in studies of ligand binding. Its application to the interaction of copper ions with bovine serum albumin and deoxyribonucleic acid  Academic Article
• Geminin regulates neuronal differentiation by antagonizing Brg1 activity  Academic Article
• Genome-wide identification of conserved intronic non-coding sequences using a Bayesian segmentation approach.  Academic Article
• Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions  Academic Article
• Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry  Academic Article
• Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets  Academic Article
• Grainyhead-like 3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton  Academic Article
• Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling  Academic Article
• High Affinity Antibodies to Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Malaria  Academic Article
• High-Resolution Crystal Structure of Plant Carboxylesterase AeCXE1, fromActinidia eriantha, and Its Complex with a High-Affinity Inhibitor Paraoxon†,‡  Academic Article
• High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat:  Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor  Academic Article
• High-resolution transcription assay for probing drug-DNA interactions at individual drug sites  Chapter
• Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain  Academic Article
• Highly Flexible Ligand Binding Pocket of Ecdysone Receptor  Academic Article
• Hijacking of a Substrate-binding Protein Scaffold for use in Mycobacterial Cell Wall Biosynthesis  Academic Article
• How insulin engages its primary binding site on the insulin receptor  Academic Article
• HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins  Academic Article
• Human Granulocyte-Macrophage Colony-Stimulating Factor (hGM-CSF): Identification of a Binding Site for a Neutralizing Antibody  Academic Article
• IAPs – the ubiquitin connection  Academic Article
• Identification of Active-Site Histidine Residues of a Self-Incompatibility Ribonuclease from a Wild Tomato  Academic Article
• Identification of Active-Site Residues of the Pro-Metastatic Endoglycosidase Heparanase†  Academic Article
• Identification of Binding Sites with Differing Affinity and Potency for Relaxin Analogues on LGR7 and LGR8 Receptors  Academic Article
• Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening  Academic Article
• Identification of a novel four-domain member of the proteinase inhibitor II family from the stigmas of Nicotiana alata  Academic Article
• Identification of intra- and intermolecular disulphide bonding in the plant mitochondrial proteome by diagonal gel electrophoresis  Academic Article
• Identification of the IgG binding site of the human low affinity receptor for IgG FcγRII. Enhancement and ablation of binding by site-directed mutagenesis  Academic Article
• Identification of the Immunoglobulin Binding Regions (IBR) of FcgammaRII and FceRI  Academic Article
• Importance of the Prime Subsites of the C1s Protease of the Classical Complement Pathway for Recognition of Substrates†  Academic Article
• In Vivo Detection of Activated Platelets Allows Characterizing Rupture of Atherosclerotic Plaques with Molecular Magnetic Resonance Imaging in Mice  Academic Article
• In silico investigation into the interactions between murine 5-HT3 receptor and the principle active compounds of ginger (Zingiber officinale)  Academic Article
• In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins  Academic Article
• Induction of stable transcriptional blockage sites by Adriamycin: GpC specificity of apparent Adriamycin-DNA adducts and dependence on iron(III) ions  Academic Article
• Inhibition of carboxypeptidase A by ketones and alcohols that are isosteric with peptide substrates  Academic Article
• Inhibition of the collagenase from Clostridium histolyticum by phosphoric and phosphonic amides  Academic Article
• Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation  Academic Article
• Insight into Schmid Metaphyseal Chondrodysplasia from the Crystal Structure of the Collagen X NC1 Domain Trimer  Academic Article
• Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL  Academic Article
• Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor  Academic Article
• Intense interval training in healthy older adults increases skeletal muscle [ 3 H]ouabain‐binding site content and elevates Na + ,K + ‐ATPase α 2 isoform abundance in Type II fibers  Academic Article
• Interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX, a solid state spectroscopy study  Academic Article
• Intron retention enhances gene regulatory complexity in vertebrates  Academic Article
• Investigations into the Binding Affinities of Different Human 5-HT4 Receptor Splice Variants  Academic Article
• Ionization states of the complex formed between 2-benzyl-3-phosphonopropionic acid and carboxypeptidase A  Academic Article
• Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues  Academic Article
• Isolation of a native osteoblast matrix with a specific affinity for BMP2  Academic Article
• Isolation of two novel myb-like genes from Arabidopsis and studies on the DNA-binding properties of their products  Academic Article
• Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B  Academic Article
• Kinetic and Crystallographic Analysis of MutantEscherichia coliAminopeptidase P:  Insights into Substrate Recognition and the Mechanism of Catalysis†  Academic Article
• Kinetic and Structural Analysis of MutantEscherichia coliDihydroorotases:  A Flexible Loop Stabilizes the Transition State†,‡  Academic Article
• Kinetics of inhibition and hysteresis of sheep liver cytoplasmic aldehyde dehydrogenase with glyoxylic acid: Further evidence relating to the two-site model for aldehyde oxidation  Academic Article
• Kinetics of reaction in calcium-activated skinned muscle fibres  Academic Article
• Length dependence of changes in sarcoplasmic calcium concentration and myofibrillar calcium sensitivity in striated muscle fibres  Academic Article
• Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences  Academic Article
• Localization of an Immunoinhibitory Epitope of the Cysteine Proteinase, Cathepsin L  Academic Article
• Loss of a histidine residue at the active site of S-locus ribonuclease is associated with self-compatibility in Lycopersicon peruvianum.  Academic Article
• Magnetic Resonance Imaging Contrast Agent Targeted Toward Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis  Academic Article
• Metal-substituted derivatives of the rubredoxin fromClostridium pasteurianum  Academic Article
• Methods to Measure the Kinetics of Protease Inhibition by Serpins  Academic Article
• Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1  Academic Article
• Mitochondrial import of rat pre-ornithine transcarbamylase: accurate processing of the precursor form is not required for uptake into mitochondria, nor assembly into catalyticaUy active enzyme  Academic Article
• Model for the Action of Calcium in Muscle  Academic Article
• Modeling the molecular basis for alpha 4 beta 1 integrin antagonism  Academic Article
• Modelling studies of the active site of human sorbitol dehydrogenase: an approach to structure-based inhibitor design of the enzyme  Academic Article
• Modelling studies on the binding of substrate and inhibitor to the active site of human sorbitol dehydrogenase  Academic Article
• Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences  Academic Article
• Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine  Academic Article
• Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1  Academic Article
• Molecular Magnetic Resonance Imaging Allows the Detection of Activated Platelets in a New Mouse Model of Coronary Artery Thrombosis  Academic Article
• Molecular basis for the folding of β-helical autotransporter passenger domains  Academic Article
• Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitor  Academic Article
• Molecular basis of the cooperative binding of Cu(I) and Cu(II) to the CopK protein from Cupriavidus metallidurans CH34  Academic Article
• Molecular characterization of the human EAA5 (GluR7) receptor: A high-affinity kainate receptor with novel potential RNA editing sites  Academic Article
• Monoclonal antibodies and synthetic peptides define the active site of FcεRI and a potential receptor antagonist  Academic Article
• Monte-Carlo simulation of multisite echinomycin-DNA interactions detected by in vitro transcription analysis  Academic Article
• Multiple Binding Sites Revealed by Interaction of Relaxin Family Peptides with Native and Chimeric Relaxin Family Peptide Receptors 1 and 2 (LGR7 and LGR8)  Academic Article
• Multiple Regions of Human FcγRII (CD32) Contribute to the Binding of IgG  Academic Article
• Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4.  Academic Article
• Murine cytomegalovirus binds reversibly to mouse embryo fibroblasts: implications for quantitation and explanation of centrifugal enhancement  Academic Article
• N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3  Academic Article
• Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition  Academic Article
• Ndufaf5 deficiency in the Dictyostelium model: new roles in autophagy and development  Academic Article
• New alleles of the wheat domestication gene Q reveal multiple roles in growth and reproductive development  Academic Article
• New insight into drug-DNA interactions at individual drug binding sites probed by RNA polymerase during active transcription of the DNA  Conference Paper
• New insights into the mechanism of dihydrodipicolinate synthase using isothermal titration calorimetry  Academic Article
• Nuclear phosphoinositides could bring FYVE alive  Academic Article
• Oestrogen modulation of the effect of 8-OH-DPAT on prepulse inhibition: effects of aromatase deficiency and castration in mice  Academic Article
• PARF‐1: an Arabidopsis thaliana FYVE‐domain protein displaying a novel eukaryotic domain structure and phosphoinositide affinity  Academic Article
• PLANT BIOLOGY: Prime Time for Cellulose  Academic Article
• POPS: A COMPUTATIONAL TOOL FOR MODELING AND PREDICTING PROTEASE SPECIFICITY  Academic Article
• PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain  Academic Article
• Paramagnetic Active Site Models for the Molybdenum−Copper Carbon Monoxide Dehydrogenase  Academic Article
• Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: Identification of key binding residues  Academic Article
• Phage display for epitope determination: A paradigm for identifying receptor–ligand interactions  Academic Article
• Photobiotin as a sensitive probe for protein labelling  Academic Article
• Physical characterization of serpin conformations  Academic Article
• PoPS: A computational tool for modeling and predicting protease specificity  Conference Paper
• PoPS: a computational tool for modeling and predicting protease specificity.  Academic Article
• Poly(ADP-ribose) polymerase at active centromeres and neocentromeres at metaphase  Academic Article
• Polymorphisms in Erythrocyte Binding Antigens 140 and 181 Affect Function and Binding but Not Receptor Specificity in Plasmodium falciparum  Academic Article
• Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor  Academic Article
• Potent Agonists of a Hematopoietic Stem Cell Cytokine Receptor, c-Mpl  Academic Article
• Potent agonists of a hematopoietic stem cell cytokine receptor, c-Mpl.  Academic Article
• Predicting miRNA-mediated gene silencing mode based on miRNA-target duplex features  Academic Article
• Predicting serpin/protease interactions  Academic Article
• Preprotein Translocase of the Outer Mitochondrial Membrane: Reconstituted Tom40 Forms a Characteristic TOM Pore  Academic Article
• Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite  Academic Article
• Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC  Academic Article
• Proteolytically active complexes of cathepsin L and a cysteine proteinase inhibitor; purification and demonstration of their formation in vitro  Academic Article
• Rapid Selection against Truncation Mutants in Yeast Reverse Two-Hybrid Screens  Academic Article
• Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors  Academic Article
• Reduced inhibitory effect of Mg2+ on ryanodine receptor-Ca2+ release channels in malignant hyperthermia  Academic Article
• Regulation of Inducible Heparanase Gene Transcription in Activated T Cells by Early Growth Response 1  Academic Article
• Regulation of Raf-1 activation and signalling by dephosphorylation  Academic Article
• Residues Surrounding the Glycosylphosphatidylinositol Anchor Attachment Site of PrP Modulate Prion Infection: Insight from the Resistance of Rabbits to Prion Disease  Academic Article
• Reversibility versus Persistence of GPIIb/IIIa Blocker-Induced Conformational Change of GPIIb/IIIa ( IIb 3, CD41/CD61)  Academic Article
• Role of Phosphatidylinositol 4,5-Bisphosphate in Ras/Rac-Induced Disruption of the Cortactin-Actomyosin II Complex and Malignant Transformation  Academic Article
• S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca²⁺ sensitivity in rat fast-twitch muscle fibers  Academic Article
• SCFCdc4-mediated Degradation of the Hac1p Transcription Factor Regulates the Unfolded Protein Response in Saccharomyces cerevisiae  Academic Article
• SFV Topoisomerase: Sequence Specificity in a Genetically Mapped Interval  Academic Article
• SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation  Academic Article
• SOMEA: self-organizing map based extraction algorithm for DNA motif identification with heterogeneous model  Academic Article
• Selective Removal of Individual Disulfide Bonds within a Potato Type II Serine Proteinase Inhibitor from Nicotiana alata Reveals Differential Stabilization of the Reactive-Site Loop  Academic Article
• Sequence Specificity of (Cyanomorpholino)adriamycin Adducts in Human Cells  Academic Article
• Sequence analysis of the nonsteroid binding component of the calf uterine estrogen receptor  Academic Article
• Sequence specificity and reactivity of the binding of phenazine-tethered platinum complexes to DNA  Academic Article
• Sequence-dependent termination of bacteriophage T7 transcription in vitro by DNA-binding drugs  Academic Article
• Shark IgNAR antibody mimotopes target a murine immunoglobulin through extended CDR3 loop structures  Academic Article
• Site-directed mutagenesis of Arg60 and Cys271 in ornithine transcarbamylase from rat liver  Academic Article
• Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1  Academic Article
• Solution structures by 1 H NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant 1 1Edited by M. F. Summers  Academic Article
• Strain-specific prion-protein conformation determined by metal ions  Academic Article
• Structural Basis for Broad Substrate Specificity in Higher Plant β-d-Glucan Glucohydrolases  Academic Article
• Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target  Academic Article
• Structural Determinants of the Interaction between the erbB2 Receptor and the Src Homology 2 Domain of Grb7  Academic Article
• Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L  Academic Article
• Structural Refinement of Insecticidal Plant Proteinase Inhibitors from Nicotiana alata  Academic Article
• Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA  Academic Article
• Structural basis for bifunctional peptide recognition at human δ-opioid receptor  Academic Article
• Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX  Academic Article
• Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan  Academic Article
• Structural basis of GDP release and gating in G protein coupled Fe2+ transport  Academic Article
• Structural determinants of cortisol resistance in the guinea pig glucocorticoid receptor  Academic Article
• Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists  Academic Article
• Structure and mechanism of a sub-family of enzymes related to N -acetylneuraminate lyase 1 1Edited by F. E. Cohen  Academic Article
• Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket  Academic Article
• Structure of Aldehyde Reductase Holoenzyme in Complex with the Potent Aldose Reductase Inhibitor Fidarestat:  Implications for Inhibitor Binding and Selectivity  Academic Article
• Structure of a calcium-deficient form of influenza virus neuraminidase: implications for substrate binding  Academic Article
• Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats  Academic Article
• Structure of an IgNAR-AMA1 Complex: Targeting a Conserved Hydrophobic Cleft Broadens Malarial Strain Recognition  Academic Article
• Structure of human aldose reductase holoenzyme in complex with Statil: An approach to structure-based inhibitor design of the enzyme  Academic Article
• Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1  Academic Article
• Structure of the Prolidase fromPyrococcus furiosus†  Academic Article
• Structure of the extracellular domains of the human interleukin-6 receptor  -chain  Academic Article
• Structure of the tetrameric form of human L-Xylulose reductase: Probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis  Academic Article
• Structure ofEscherichia coliaminopeptidase P in complex with the inhibitor apstatin  Academic Article
• Structure-based design of inhibitors of human l-xylulose reductase modelled into the active site of the enzyme  Academic Article
• Structure-guided design of a novel class of benzyl-sulfonate inhibitors for influenza virus neuraminidase  Academic Article
• Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design  Academic Article
• Studies on 3-Deoxy-d-arabinoheptulosonate-7-phosphate Synthetase(phe) from Escherichia coli K12. 3. Structural Studies  Academic Article
• Studies on the cell surface of zoospores and cysts of the fungus Phytophthora cinnamomi: nature of the surface saccharides as determined by quantitative lectin binding studies.  Academic Article
• Synthesis and Structure Determination by NMR of a Putative Vacuolar Targeting Peptide and Model of a Proteinase Inhibitor fromNicotiana alata†,‖  Academic Article
• Synthesis and effects of conjugated tocopherol analogues on peptide nucleic acid hybridisation  Academic Article
• Synthesis, Testing and Structure-Activity Studies on a Library of 5-HT4 Ligands  Academic Article
• Synthesis, binding and bioactivity of γ-methylene γ-lactam ecdysone receptor ligands: Advantages of QSAR models for flexible receptors  Academic Article
• Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines  Academic Article
• Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex  Academic Article
• Targeted Antithrombotic Protein Micelles  Academic Article
• Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands  Academic Article
• Targeting the Role of a Key Conserved Motif for Substrate Selection and Catalysis by 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthase  Academic Article
• Tension changes in isolated muscle fibres as predicted by the free calcium concentration.  Academic Article
• Ternary structure reveals mechanism of a membrane diacylglycerol kinase  Academic Article
• The Assessment and Characterisation of Drug Plasma Protein Binding in the Body Using QSAR  Academic Article
• The Biomolecular Interaction Network Database and related tools 2005 update  Academic Article
• The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages  Academic Article
• The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch  Academic Article
• The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis  Academic Article
• The High Resolution Crystal Structure of the Human Tumor Suppressor Maspin Reveals a Novel Conformational Switch in the G-helix  Academic Article
• The Initiation of GTP Hydrolysis by the G-Domain of FeoB: Insights from a Transition-State Complex Structure  Academic Article
• The Intestinal Epithelial Cell Differentiation Marker Intestinal Alkaline Phosphatase (ALPi) Is Selectively Induced by Histone Deacetylase Inhibitors (HDACi) in Colon Cancer Cells in a Kruppel-like Factor 5 (KLF5)-dependent Manner  Academic Article
• The Junction-associated Protein AF-6 Interacts and Clusters with Specific Eph Receptor Tyrosine Kinases at Specialized Sites of Cell–Cell Contact in the Brain  Academic Article
• The Membrane-Bound NAC Transcription Factor ANAC013 Functions in Mitochondrial Retrograde Regulation of the Oxidative Stress Response in Arabidopsis  Academic Article
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• The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors  Academic Article
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• The crystal structures of a copper-bound metallochaperone from Saccharomyces Cerevisiae  Academic Article
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• The isolation of plasma membranes from the cellular slime moldDictyostelium discoideumusing concanavalin A and triton X-100  Academic Article
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• The mouse Plk gene: structural characterization, chromosomal localization and identification of a processed Plk pseudogene  Academic Article
• The prion protein gene: Identifying regulatory signals using marsupial sequence  Academic Article
• The self-association of l-α-hydroxyacid oxidase  Academic Article
• The solution structure of C1-T1, a two-domain proteinase inhibitor derived from a circular precursor protein from Nicotiana alata11Edited by P. E. Wright  Academic Article
• The structure and activity of the glutathione reductase from Streptococcus pneumoniae  Academic Article
• The structure of an N11A mutant of the G-protein domain of FeoB  Academic Article
• The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates  Academic Article
• The upstream limit of nuclease-sensitive chromatin in Dictyostelium rRNA genes neighbors a topoisomerase I-like cluster  Academic Article
• Therapeutic integrin inhibition: Allosteric and activation-specific inhibition strategies may surpass the initial ligand-mimetic strategies  Academic Article
• Thermodynamics of the interaction of daunomycin with DNA  Academic Article
• Thioredoxin A Active-Site Mutants Form Mixed Disulfide Dimers That Resemble Enzyme–Substrate Reaction Intermediates  Academic Article
• Three-dimensional localization of CENP-A suggests a complex higher order structure of centromeric chromatin  Academic Article
• Transcriptional analysis of multisite drug-DNA dissociation kinetics: delayed termination of transcription by actinomycin D  Academic Article
• Transforming a Fructan:Fructan 6G-Fructosyltransferase from Perennial Ryegrass into a Sucrose:Sucrose 1-Fructosyltransferase  Academic Article
• Transition-State Analogue γ-Secretase Inhibitors Stabilize a 900 kDa Presenilin/Nicastrin Complex†  Academic Article
• Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites  Academic Article
• Translocation of Proteins into Mitochondria  Academic Article
• Turnover of proteoglycans in articular-cartilage cultures. Characterization of proteoglycans released into the medium  Academic Article
• Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with fidarestat and minalrestat: Implications for the binding of cyclic imide inhibitors  Academic Article
• Unchanged [3H]ouabain binding site content but reduced Na +-K+ pump α2-protein abundance in skeletal muscle in older adults  Academic Article
• Unlike Diablo/smac, Grim Promotes Global Ubiquitination and Specific Degradation of X Chromosome-linked Inhibitor of Apoptosis (XIAP) and Neither Cause Apoptosis  Academic Article
• Use of a Biosensor with Surface Plasmon Resonance Detection for the Determination of Binding Constants: Measurement of Interleukin-6 Binding to the Soluble Interleukin-6 Receptor  Academic Article
• Use of oligonucletides to define the site of interstand cross-links induced by Adriamycin  Academic Article
• Useful Vectors for the Two-Hybrid System in Mammalian Cells  Academic Article
• Visualization of Activated Platelets by Targeted Magnetic Resonance Imaging Utilizing Conformation-Specific Antibodies against Glycoprotein IIb/IIIa  Academic Article
• Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells  Academic Article
• Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse  Academic Article
• X-ray Absorption Spectroscopy of Selenate Reductase  Academic Article
• X-ray crystal structure of MENT: evidence for functional loop–sheet polymers in chromatin condensation  Academic Article
• i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4  Academic Article