subject area of

• A Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation  Academic Article
• A Review: Biological and Clinical Aspects of Pyrimidine Metabolism  Academic Article
• A Tumor Cell-Specific Nuclear Targeting Signal within Chicken Anemia Virus VP3/Apoptin  Academic Article
• A hypermorphic epithelial beta-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations  Academic Article
• Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers  Academic Article
• Analysis of Ras-induced oncogenic transformation of NIH-3T3 cells using differential-display 2-DE proteomics  Academic Article
• Antiviral and Antiproliferative Activities of Interferon-α1: The Role of Cysteine Residues  Academic Article
• Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species  Academic Article
• Bcl-2 family proteins: The sentinels of the mitochondrial apoptosis pathway  Academic Article
• Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells  Academic Article
• Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic  Academic Article
• Cartilage proteoglycan degradation by a mouse transformed macrophage cell line is mediated by macrophage metalloelastase  Academic Article
• Cellular Mechanisms of Risk and Transformation  Conference Paper
• Colorectal cancer mouse models: integrating inflammation and the stroma  Academic Article
• Differential effects of DNA synthesis inhibitors on DNA methylation in normal and transformed cells  Academic Article
• Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis  Academic Article
• Drosophila models of cell polarity and cell competition in tumourigenesis  Chapter
• ELF3, ELF5, EHF and SPDEF transcription factors in tissue homeostasis and cancer  Academic Article
• Early work on the function of Bcl-2, an interview with David Vaux  Academic Article
• Effect of thymidine analogs on tyrosinase activity and mRNA accumulation in mouse melanoma cells  Academic Article
• Effects of Sodium Butyrate on the Synthesis and Methylation of DNA in Normal Cells and Their Transformed Counterparts  Academic Article
• Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression  Academic Article
• Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia  Academic Article
• Environment-gene interactions in intestinal cancer  Conference Paper
• Eph/Ephrin Signalling and Function in Oncogenesis: Lessons from Embryonic Development  Academic Article
• Epithelial gp130/Stat3 functions: An intestinal signaling node in health and disease  Academic Article
• Extracellular Remodelling During Oncogenic Ras-Induced Epithelial-Mesenchymal Transition Facilitates MDCK Cell Migration  Academic Article
• HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition  Academic Article
• High-Contrast PET of Melanoma Using 18F-MEL050, a Selective Probe for Melanin with Predominantly Renal Clearance  Academic Article
• Human ERG is a proto-oncogene with mitogenic and transforming activity  Academic Article
• Immuno-PET Quantitation of de2-7 Epidermal Growth Factor Receptor Expression in Glioma Using 124I-IMP-R4-Labeled Antibody ch806  Academic Article
• In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling  Academic Article
• Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism  Academic Article
• Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9  Academic Article
• Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-γ–Dependent Manner  Academic Article
• Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically  Academic Article
• Is CD1a involved in antitumour immune responses during carcinogenesis?  Academic Article
• Kaiso-Deficient Mice Show Resistance to Intestinal Cancer  Academic Article
• Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner  Academic Article
• Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice  Academic Article
• Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling  Academic Article
• Loss of the EPH receptor B6 contributes to colorectal cancer metastasis  Academic Article
• Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism  Academic Article
• Malignant transformation of oral submucous fibrosis: overview of histopathological aspects  Academic Article
• Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with Zr-89-DS-8895a  Academic Article
• Molecular Pathology of Malignant Transformation of Oral Submucous Fibrosis  Academic Article
• Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers  Academic Article
• Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability  Academic Article
• Oncogenic B-Raf mutations  Academic Article
• Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Exosomal Proteins Following Epithelial-Mesenchymal Transition  Academic Article
• Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells  Academic Article
• OncogenicK-RASIs Required to Maintain Changes in Cytoskeletal Organization, Adhesion, and Motility in Colon Cancer Cells  Academic Article
• Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer  Academic Article
• Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation  Academic Article
• Preclinical characterization of 18F-D-FPHCys, a new amino acid-based PET tracer  Academic Article
• Regulation of Nuclear Transport: Central Role in Development and Transformation?  Academic Article
• Role of Phosphatidylinositol 4,5-Bisphosphate in Ras/Rac-Induced Disruption of the Cortactin-Actomyosin II Complex and Malignant Transformation  Academic Article
• SCL, the gene implicated in human T-cell leukaemia, is oncogenic in a murine T-lymphocyte cell line  Academic Article
• Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo  Academic Article
• Secretome-Based Proteomic Profiling of Ras-Transformed MDCK Cells Reveals Extracellular Modulators of Epithelial-Mesenchymal Transition  Academic Article
• T-cell receptor and immunoglobulin genes are rearranged together in Abelson virus-transformed pre-B and pre-T cells.  Academic Article
• Targeting EphA3 inhibits cancer growth by disrupting the tumor stromal microenvironment  Academic Article
• Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis  Academic Article
• The EGFRvIII variant in glioblastoma multiforme  Academic Article
• The Phosphoprotein StarD10 Is Overexpressed in Breast Cancer and Cooperates with ErbB Receptors in Cellular Transformation  Academic Article
• The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis  Academic Article
• The Scribble-Dlg-Lgl polarity module in development and cancer: From flies to man  Academic Article
• The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy  Academic Article
• The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy  Academic Article
• Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map  Academic Article
• Towards understanding epithelial–mesenchymal transition: A proteomics perspective  Academic Article
• Transformation of Astrocytes in Transgenic Mice Expressing SV40 T Antigen under the Transcriptional Control of the Glial Fibrillary Acidic Protein Promoter  Academic Article
• Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis  Academic Article
• Transforming growth factor(s) production enables cells to grow in the absence of serum: an autocrine system.  Academic Article
• Tumour targeting of Auger emitters using DNA ligands conjugated to octreotate  Conference Paper
• scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs  Academic Article
• β-Catenin/Tcf-4 Inhibition After Progastrin Targeting Reduces Growth and Drives Differentiation of Intestinal Tumors  Academic Article