subject area of

• A pharmacological study of NLP-12 neuropeptide signaling in free-living and parasitic nematodes  Academic Article
• AKP-11 - A novel S1P1 agonist with favorable safety profile attenuates experimental autoimmune encephalomyelitis in rat model of multiple sclerosis  Academic Article
• Abciximab, Eptifibatide, and Tirofiban Exhibit Dose-dependent Potencies to Dissolve Platelet Aggregates  Academic Article
• Adhesion of Monocytes to Medical Steel as Used for Vascular Stents is Mediated by the Integrin Receptor Mac-1 (CD11b/CD18; α M β 2 ) and Can be Inhibited by Semiconductor Coating  Academic Article
• Analysis of heat shock protein 70 in human chromosome 21 containing hybrids  Academic Article
• Arginine-Specific Protease fromPorphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion  Academic Article
• Binding activity of glucocorticoid receptors after heat shock  Academic Article
• Binding of CD40L to Mac-1's I-Domain Involves the EQLKKSKTL Motif and Mediates Leukocyte Recruitment and Atherosclerosis—But Does Not Affect Immunity and Thrombosis in Mice  Academic Article
• CD40 Ligand Mediates Inflammation Independently of CD40 by Interaction With Mac-1  Academic Article
• Capadenoson, a clinically trialed partial adenosine A 1 receptor agonist, can stimulate adenosine A 2B receptor biased agonism  Academic Article
• Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity  Academic Article
• Differential modulation of Alzheimer's disease amyloid β-peptide accumulation by diverse classes of metal ligands  Academic Article
• Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues  Academic Article
• Distinct roles of ligand affinity and cytoskeletal anchorage in αIIbβ3(GP IIb/IIIa)-mediated cell aggregation and adhesion  Academic Article
• Disulfide Bond Structure andN-Glycosylation Sites of the Extracellular Domain of the Human Interleukin-6 Receptor  Academic Article
• Dual-modality NIRF-MRI cubosomes and hexosomes: High throughput formulation and in vivo biodistribution  Academic Article
• EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit.  Academic Article
• Effects of Mutations in the Cytoplasmic Domain of Integrin β1 to Talin Binding and Cell Spreading  Academic Article
• Elevation in Sphingomyelin Synthase Activity Is Associated with Increases in Amyloid-Beta Peptide Generation  Academic Article
• Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR  Academic Article
• Enzymatic Single-Chain Antibody Tagging  Academic Article
• Epitope Mapping of the Transforming Growth Factor-β Superfamily Protein, Macrophage Inhibitory Cytokine-1 (MIC-1):  Identification of at Least Five Distinct Epitope Specificities†  Academic Article
• Evidence for a differential functional regulation of the two β3-integrins αVβ3 and αIIbβ3  Academic Article
• Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes  Academic Article
• Expression of a TGF-β superfamily protein, macrophage inhibitory cytokine-1, in the yeast Pichia pastoris  Academic Article
• Expression of recombinant soluble FcεRI: Function and tissue distribution studies  Academic Article
• Generation of activation-specific human anti-αMβ2 single-chain antibodies as potential diagnostic tools and therapeutic agents  Academic Article
• Genetic transfer of fusion proteins effectively inhibits VCAM-1-mediated cell adhesion and transmigration via inhibition of cytoskeletal anchorage  Academic Article
• Glycosylation Defect in Lec1 Chinese Hamster Ovary Mutant Is Due to a Point Mutation inN-Acetylglucosaminyltransferase I Gene  Academic Article
• Heat-induced Alterations in the Localization of HSP72 and HSP73 as Measured by Indirect Immunohistochemistry and Immunogold Electron Microscopy  Academic Article
• Histidine-rich Glycoprotein Binds to Cell-surface Heparan Sulfate via Its N-terminal Domain following Zn2+ Chelation  Academic Article
• Histidine-rich Glycoprotein Specifically Binds to Necrotic Cells via Its Amino-terminal Domain and Facilitates Necrotic Cell Phagocytosis  Academic Article
• Human IgG Monoclonal Anti-αIIbβ3-Binding Fragments Derived from Immunized Donors Using Phage Display  Academic Article
• IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3  Academic Article
• Impact of 27-Hydroxycholesterol on Amyloid-β Peptide Production and ATP-Binding Cassette Transporter Expression in Primary Human Neurons  Academic Article
• Improving selection of αIIbβ3-binding phage antibodies with increased reactivity derived from immunized donors  Academic Article
• Induction of Fibrinogen Binding and Platelet Aggregation as a Potential Intrinsic Property of Various Glycoprotein IIb/IIIa (IIbβ3) Inhibitors  Academic Article
• Inhibition of interleukin 1 -converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP  Conference Paper
• Inhibition of γ‐secretase causes increased secretion of amyloid precursor protein C‐terminal fragments in association with exosomes  Academic Article
• Insulin and Oleate Promote Translocation of Inosine-5′ Monophosphate Dehydrogenase to Lipid Bodies  Academic Article
• Integrin cytoplasmic domains mediate inside-out signal transduction  Academic Article
• Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis  Academic Article
• Localization of the Gene Encoding the Human Heat Shock Cognate Protein, HSP73, to Chromosome 11  Academic Article
• Modulation of amyloid precursor protein processing by synthetic ceramide analogues  Academic Article
• Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction.  Academic Article
• Modulation of voltage-gated K+ channels by the sodium channel  1 subunit  Academic Article
• Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast  Academic Article
• Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis  Academic Article
• Non-lamellar lyotropic liquid crystalline nanoparticles enhance the antibacterial effects of rifampicin against Staphylococcus aureus  Academic Article
• PSGL-1-Mediated Adhesion of Human Hematopoietic Progenitors to P-Selectin Results in Suppression of Hematopoiesis  Academic Article
• Platelet-targeted delivery of peripheral blood mononuclear cells to the ischemic heart restores cardiac function after ischemia-reperfusion injury  Academic Article
• Promotion of Leukocyte Adhesion by a Novel Interaction Between Vitronectin and the β2Integrin Mac-1 (αMβ2, CD11b/CD18)  Academic Article
• Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease ?-amyloid protein precursor: Effect of C-terminal truncation on production of ?-amyloid protein  Academic Article
• Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells  Academic Article
• Recombinant CLIC1 (NCC27) Assembles in Lipid Bilayers via a pH-dependent Two-state Process to Form Chloride Ion Channels with Identical Characteristics to Those Observed in Chinese Hamster Ovary Cells Expressing CLIC1  Academic Article
• Recombinant human antibodies: linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture  Academic Article
• Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage  Academic Article
• Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid-β Peptide Generation  Academic Article
• Roles of Mac-1 and glycoprotein IIb/IIIa integrins in leukocyte–platelet aggregate formation: Stabilization by Mac-1 and inhibition by GpIIb/IIIa blockers  Academic Article
• Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-β Peptide  Academic Article
• Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34⁺ hemopoietic progenitor cells  Academic Article
• Single‐chain antibodies for the conformation‐specific blockade of activated platelet integrin α IIb β 3 designed by subtractive selection from naïve human phage libraries  Academic Article
• Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice  Academic Article
• Striking Immunodominance Hierarchy of Naturally Occurring CD8+ and CD4+ T Cell Responses to Tumor Antigen NY-ESO-1  Academic Article
• Structural Requirements for Assembly of Dimeric IgA Probed by Site-Directed Mutagenesis of J Chain and a Cysteine Residue of the α-Chain CH2 Domain  Academic Article
• Structural Requirements for the Interaction of Human IgA with the Human Polymeric Ig Receptor  Academic Article
• Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists  Academic Article
• Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): Implications on imaging of atherosclerotic plaques  Academic Article
• The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors  Academic Article
• The Propeptide of the Transforming Growth Factor-β Superfamily Member, Macrophage Inhibitory Cytokine-1 (MIC-1), Is a Multifunctional Domain That Can Facilitate Protein Folding and Secretion  Academic Article
• The extracellular surface of the GLP-1 receptor Is a molecular trigger for biased agonism  Academic Article
• The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-β superfamily member, acts as a quality control determinant for correctly folded MIC-1  Academic Article
• The self peptide annexin II (208–223) presented by dendritic cells sensitizes autologous CD4+ T lymphocytes to recognize melanoma cells  Academic Article
• Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis  Academic Article
• Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with α9β1 and α4β1 integrins  Academic Article
• Towards effective and safe thrombolysis and thromboprophylaxis  Academic Article
• Tumour-specific MHC-class-II-restricted responses after in vitro sensitization to synthetic peptides corresponding to gp100 and Annexin II eluted from melanoma cells  Academic Article
• Vacuolation Activity and Intracellular Trafficking of ArtB, the Binding Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi  Academic Article
• Wild type and tangier disease ABCA1 mutants modulate cellular amyloid-β production independent of cholesterol efflux activity  Academic Article