subject area of

• A 22-mer Segment in the Structurally Pliable Regulatory Domain of Metazoan CTP: Phosphocholine Cytidylyltransferase Facilitates Both Silencing and Activating Functions  Academic Article
• A Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation  Academic Article
• A Serpentine Receptor-Dependent, Gβ- and Ca2+ Influx-Independent Pathway Regulates Mitogen-Activated Protein Kinase ERK2 in Dictyostelium  Academic Article
• A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis  Academic Article
• A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites  Academic Article
• A novel Apaf-1–independent putative caspase-2 activation complex  Academic Article
• A selective glutathione probe based on AIE Fluorogen and its application in enzymatic activity assay  Academic Article
• A single amino acid change in the plant alternative oxidase alters the specificity of organic acid activation  Academic Article
• A type III effector antagonizes death receptor signalling during bacterial gut infection  Academic Article
• APOPTOSIS: A Cinderella Caspase Takes Center Stage  Academic Article
• Activation of NAD-linked malic enzyme in intact plant mitochondria by exogenous coenzyme A  Academic Article
• Activation of Pollen Tube Callose Synthase by Detergents (Evidence for Different Mechanisms of Action)  Academic Article
• Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide  Academic Article
• Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal  Academic Article
• Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation  Academic Article
• Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death  Academic Article
• Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits  Academic Article
• Alternative oxidase isoforms are differentially activated by tricarboxylic acid cycle intermediate  Academic Article
• Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity  Academic Article
• Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells  Academic Article
• Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate  Academic Article
• Annexin Peptide Ac2-26 Suppresses TNFα-Induced Inflammatory Responses via Inhibition of Rac1-Dependent NADPH Oxidase in Human Endothelial Cells  Academic Article
• Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2  Academic Article
• Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome  Academic Article
• Are reactive oxygen species still the basis for diabetic complications?  Academic Article
• Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity  Academic Article
• Broad yet high substrate specificity: the challenge of AAA+ proteins  Academic Article
• CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK  Academic Article
• CR1/CR2 Interactions Modulate the Functions of the Cell Surface Epidermal Growth Factor Receptor  Academic Article
• CSF-1 receptor signalling from endosomes mediates the sustained activation of Erk1/2 and Akt in macrophages  Academic Article
• CaMKIIδ and cardiomyocyte Ca²⁺ signalling new perspectives on splice variant targeting  Conference Paper
• Calpains in muscle: selective and protective?  Editorial Article
• Cardioprotection from ischaemia–reperfusion injury by a novel flavonol that reduces activation of p38 MAPK  Academic Article
• Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF (cyclin F) complex  Academic Article
• Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7  Academic Article
• Caspase-2: controversial killer or checkpoint controller?  Academic Article
• Catabolism of Aggrecan by Explant Cultures of Human Articular Cartilage in the Presence of Retinoic Acid  Academic Article
• Cell Death in Development  Academic Article
• Cell signalling and the hormonal stimulation of the hepatic glycine cleavage enzyme system by glucagon  Academic Article
• Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival  Academic Article
• Changes in the levels of enzymes which modulate the antioxidant balance occur during aging and correlate with cellular damage  Academic Article
• Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R fromPorphyromonas gingivalis  Academic Article
• Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response  Academic Article
• Controlling TRAIL-mediated caspase-3 activation  Academic Article
• Conversion of Trypsin into a Na+-Activated Enzyme†,‡  Academic Article
• Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense  Academic Article
• Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259  Academic Article
• Death in the snow: report on Keystone Conference on ‘Apoptosis and Programmed Cell Death’ at Breckenridge, CO, April 6–11th 1999  Conference Paper
• Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9  Academic Article
• Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2  Academic Article
• Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP  Academic Article
• Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: Initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (Δψ(m))  Academic Article
• Distinct requirements for the Sprouty domain for functional activity of Spred proteins  Academic Article
• Distribution and activation of matrix metalloproteinase-2 in skeletal muscle fibers  Academic Article
• Dynamic modelling reveals 'hotspots' on the pathway to enzyme-substrate complex formation  Academic Article
• Enzymatic Properties of an Ecto-nucleoside Triphosphate Diphosphohydrolase fromLegionella pneumophila  Academic Article
• Evidence That Estrogen Suppresses Rho-Kinase Function in the Cerebral Circulation In Vivo  Academic Article
• Evolution of Quaternary Structure in a Homotetrameric Enzyme  Academic Article
• Examination of the role of the proteolytically-activated form of protein kinase C in the differentiation of human haemopoietic cells  Academic Article
• Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine  Academic Article
• Flow-Induced Cerebral Vasodilatation in Vivo Involves Activation of Phosphatidylinositol-3 Kinase, NADPH-Oxidase, and Nitric Oxide Synthase  Academic Article
• Functional Relevance of Golgi- and Plasma Membrane-Localized Endothelial NO Synthase in Reconstituted Endothelial Cells  Academic Article
• GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop  Academic Article
• Granzyme M Mediates a Novel Form of Perforin-dependent Cell Death  Academic Article
• Heat Shock Protein 72 Modulates Pathways of Stress-induced Apoptosis  Academic Article
• Helicobacter pyloriInduces MAPK Phosphorylation and AP-1 Activation via a NOD1-Dependent Mechanism  Academic Article
• Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B  Academic Article
• Hsp72 Inhibits Apoptosis Upstream of the Mitochondria and Not through Interactions with Apaf-1  Academic Article
• In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling  Academic Article
• In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8  Academic Article
• Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury  Academic Article
• Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation  Academic Article
• Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation  Conference Paper
• Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors  Academic Article
• Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin b and an inhibitor of matrix metalloproteinases. evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation  Academic Article
• Inhibition of heat shock protein 70 blocks the development of cardiac hypertrophy by modulating the phosphorylation of histone deacetylase 2  Academic Article
• Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells  Academic Article
• Inhibitory Effects of Protein Kinase C on Inwardly Rectifying K + - and ATP-Sensitive K + Channel-Mediated Responses of the Basilar Artery  Academic Article
• Intact Mitochondrial Electron Transport Function is Essential for Signalling by Hydrogen Peroxide in Cardiac Myocytes  Academic Article
• Ischemia‐induced phosphorylation of phospholemman directly activates rat cardiac Na/K ATPase  Academic Article
• JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity  Academic Article
• Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling  Academic Article
• MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial-mesenchymal transition traits  Academic Article
• Mammalian initiator apoptotic caspases  Academic Article
• Mechanisms of Inactivation of the Receptor Tyrosine Kinase EPHB2 in Colorectal Tumors  Academic Article
• Microfluorometric analyses of glycogen in freshly dissected, single skeletal muscle fibres of the cane toad using a mechanically skinned fibre preparation  Academic Article
• Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid  Academic Article
• Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1  Academic Article
• Molecular Determinants of the Substrate Specificity of the Complement-initiating Protease, C1r  Academic Article
• Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells  Academic Article
• Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop  Academic Article
• Novel Mechanism of Activation of NADPH Oxidase 5  Academic Article
• Old and Novel Functions of Caspase-2  Chapter
• Organic acid activation of the alterNatlve oxidase of plant mitochondria  Academic Article
• P2Y receptor signaling regulates phenotype and IFN-α secretion of human plasmacytoid dendritic cells  Academic Article
• POPS: A COMPUTATIONAL TOOL FOR MODELING AND PREDICTING PROTEASE SPECIFICITY  Academic Article
• Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits  Academic Article
• Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite  Academic Article
• Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC  Academic Article
• Progranulin does not inhibit TNF and lymphotoxin-signalling through TNF receptor 1  Academic Article
• Protein kinase C and downstream signaling pathways in a three-dimensional model of phorbol ester-induced angiogenesis  Academic Article
• Proton pump inhibitors, genetic polymorphisms and response to clopidogrel therapy  Academic Article
• RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL  Academic Article
• ROLE OF p38-MITOGEN-ACTIVATED PROTEIN KINASE IN ISCHAEMIC PRECONDITIONING IN RAT HEART  Academic Article
• Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation  Academic Article
• Reduced Phosphoinositide 3-Kinase (p110α) Activation Increases the Susceptibility to Atrial Fibrillation  Academic Article
• Regulation of Enterocyte Apoptosis by Acyl-CoA Synthetase 5 Splicing  Academic Article
• Regulation of Raf-1 activation and signalling by dephosphorylation  Academic Article
• Regulation of alternative oxidase activity in higher plants  Academic Article
• Requirements for proteolysis during apoptosis.  Academic Article
• Scabies Mite Inactivated Serine Protease Paralogs Inhibit the Human Complement System  Academic Article
• Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo  Academic Article
• Short-chain fatty acids reduce expression of specific protein kinase C isoforms in human colonic epithelial cells  Academic Article
• Signalling pathways activated by hydrogen peroxide in vascular smooth muscle  Academic Article
• Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization  Academic Article
• Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI  Academic Article
• Structural Mechanisms of Inactivation in Scabies Mite Serine Protease Paralogues  Academic Article
• Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates  Academic Article
• SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase  Academic Article
• TRAIL Induces Receptor-Interacting Protein 1–Dependent and Caspase-Dependent Necrosis-Like Cell Death under Acidic Extracellular Conditions  Academic Article
• The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast  Academic Article
• The Elusive Role of the Potential Factor X Cation-binding Exosite-1 in Substrate and Inhibitor Interactions  Academic Article
• The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury  Academic Article
• The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation  Academic Article
• The Phytocalpain Defective Kernel 1 Is a Novel Arabidopsis Growth Regulator Whose Activity Is Regulated by Proteolytic Processing  Academic Article
• The Plasticity of Oncogene Addiction: Implications for Targeted Therapies Directed to Receptor Tyrosine Kinases  Academic Article
• The Soluble Guanylyl Cyclase Activator Bay 58-2667 Selectively Limits Cardiomyocyte Hypertrophy  Academic Article
• The UBA domain of SnRK1 promotes activation and maintains catalytic activity  Academic Article
• The X-ray Crystal Structure of Full-Length Human Plasminogen  Academic Article
• The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome  Academic Article
• The molecular biology of apoptosis.  Academic Article
• The protective effects of exercise and phosphoinositide 3-kinase (p110α) in the failing heart  Academic Article
• Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins  Academic Article
• Ultramarine, a Chromoprotein Acceptor for Förster Resonance Energy Transfer  Academic Article
• Unraveling the Redox Properties of the Global Regulator FurA from Anabaena sp PCC 7120: Disulfide Reductase Activity Based on Its CXXC Motifs  Academic Article
• Untying the regulation of the Raf-1 kinase  Academic Article
• X-ray Induced Activity of N-Ethylmaleimide-Sensitive DNA Polymerase in Chinese Hamster Cells  Academic Article
• XIAP discriminates between type I and type II FAS-induced apoptosis  Academic Article
• cdc25 M-phase Inducer  Academic Article
• gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways  Academic Article