Enzyme Activation
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A Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation Academic Article
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A Serpentine Receptor-Dependent, Gβ- and Ca2+ Influx-Independent Pathway Regulates Mitogen-Activated Protein Kinase ERK2 in Dictyostelium Academic Article
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A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis Academic Article
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A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites Academic Article
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A novel Apaf-1–independent putative caspase-2 activation complex Academic Article
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A selective glutathione probe based on AIE Fluorogen and its application in enzymatic activity assay Academic Article
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A single amino acid change in the plant alternative oxidase alters the specificity of organic acid activation Academic Article
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A type III effector antagonizes death receptor signalling during bacterial gut infection Academic Article
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APOPTOSIS: A Cinderella Caspase Takes Center Stage Academic Article
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Activation of NAD-linked malic enzyme in intact plant mitochondria by exogenous coenzyme A Academic Article
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Activation of Pollen Tube Callose Synthase by Detergents (Evidence for Different Mechanisms of Action) Academic Article
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Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide Academic Article
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Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal Academic Article
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Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation Academic Article
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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death Academic Article
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Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits Academic Article
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Alternative oxidase isoforms are differentially activated by tricarboxylic acid cycle intermediate Academic Article
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Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity Academic Article
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An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling Academic Article
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Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells Academic Article
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Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate Academic Article
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Annexin Peptide Ac2-26 Suppresses TNFα-Induced Inflammatory Responses via Inhibition of Rac1-Dependent NADPH Oxidase in Human Endothelial Cells Academic Article
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Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2 Academic Article
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Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome Academic Article
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Are reactive oxygen species still the basis for diabetic complications? Academic Article
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Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity Academic Article
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Broad yet high substrate specificity: the challenge of AAA+ proteins Academic Article
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CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK Academic Article
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CR1/CR2 Interactions Modulate the Functions of the Cell Surface Epidermal Growth Factor Receptor Academic Article
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CSF-1 receptor signalling from endosomes mediates the sustained activation of Erk1/2 and Akt in macrophages Academic Article
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CaMKIIδ and cardiomyocyte Ca2+ signalling new perspectives on splice variant targeting Conference Paper
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Calpains in muscle: selective and protective? Editorial Article
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Cardioprotection from ischaemia–reperfusion injury by a novel flavonol that reduces activation of p38 MAPK Academic Article
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Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF (cyclin F) complex Academic Article
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Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7 Academic Article
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Caspase-2: controversial killer or checkpoint controller? Academic Article
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Catabolism of Aggrecan by Explant Cultures of Human Articular Cartilage in the Presence of Retinoic Acid Academic Article
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Cell Death in Development Academic Article
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Cell signalling and the hormonal stimulation of the hepatic glycine cleavage enzyme system by glucagon Academic Article
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Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival Academic Article
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Changes in the levels of enzymes which modulate the antioxidant balance occur during aging and correlate with cellular damage Academic Article
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Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R fromPorphyromonas gingivalis Academic Article
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Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response Academic Article
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Controlling TRAIL-mediated caspase-3 activation Academic Article
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Conversion of Trypsin into a Na+-Activated Enzyme†,‡ Academic Article
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Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense Academic Article
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Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259 Academic Article
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Death in the snow: report on Keystone Conference on ‘Apoptosis and Programmed Cell Death’ at Breckenridge, CO, April 6–11th 1999 Conference Paper
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Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9 Academic Article
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Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2 Academic Article
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Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP Academic Article
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Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: Initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (Δψ(m)) Academic Article
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Distinct requirements for the Sprouty domain for functional activity of Spred proteins Academic Article
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Distribution and activation of matrix metalloproteinase-2 in skeletal muscle fibers Academic Article
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Dynamic modelling reveals 'hotspots' on the pathway to enzyme-substrate complex formation Academic Article
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Enzymatic Properties of an Ecto-nucleoside Triphosphate Diphosphohydrolase fromLegionella pneumophila Academic Article
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Evidence That Estrogen Suppresses Rho-Kinase Function in the Cerebral Circulation In Vivo Academic Article
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Evolution of Quaternary Structure in a Homotetrameric Enzyme Academic Article
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Examination of the role of the proteolytically-activated form of protein kinase C in the differentiation of human haemopoietic cells Academic Article
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Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine Academic Article
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Flow-Induced Cerebral Vasodilatation in Vivo Involves Activation of Phosphatidylinositol-3 Kinase, NADPH-Oxidase, and Nitric Oxide Synthase Academic Article
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Functional Relevance of Golgi- and Plasma Membrane-Localized Endothelial NO Synthase in Reconstituted Endothelial Cells Academic Article
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GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop Academic Article
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Granzyme M Mediates a Novel Form of Perforin-dependent Cell Death Academic Article
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Heat Shock Protein 72 Modulates Pathways of Stress-induced Apoptosis Academic Article
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Helicobacter pyloriInduces MAPK Phosphorylation and AP-1 Activation via a NOD1-Dependent Mechanism Academic Article
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Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B Academic Article
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Hsp72 Inhibits Apoptosis Upstream of the Mitochondria and Not through Interactions with Apaf-1 Academic Article
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In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling Academic Article
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In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8 Academic Article
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Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury Academic Article
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Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation Academic Article
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Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation Conference Paper
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Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors Academic Article
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Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin b and an inhibitor of matrix metalloproteinases. evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation Academic Article
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Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells Academic Article
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Inhibitory Effects of Protein Kinase C on Inwardly Rectifying K
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Channel-Mediated Responses of the Basilar Artery Academic Article
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Intact Mitochondrial Electron Transport Function is Essential for Signalling by Hydrogen Peroxide in Cardiac Myocytes Academic Article
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Ischemia‐induced phosphorylation of phospholemman directly activates rat cardiac Na/K ATPase Academic Article
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JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity Academic Article
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Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling Academic Article
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MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial-mesenchymal transition traits Academic Article
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Mammalian initiator apoptotic caspases Academic Article
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Mechanisms of Inactivation of the Receptor Tyrosine Kinase EPHB2 in Colorectal Tumors Academic Article
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Microfluorometric analyses of glycogen in freshly dissected, single skeletal muscle fibres of the cane toad using a mechanically skinned fibre preparation Academic Article
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Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid Academic Article
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Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1 Academic Article
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Molecular Determinants of the Substrate Specificity of the Complement-initiating Protease, C1r Academic Article
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Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells Academic Article
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Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop Academic Article
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Novel Mechanism of Activation of NADPH Oxidase 5 Academic Article
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Old and Novel Functions of Caspase-2 Chapter
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Organic acid activation of the alterNatlve oxidase of plant mitochondria Academic Article
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P2Y receptor signaling regulates phenotype and IFN-α secretion of human plasmacytoid dendritic cells Academic Article
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POPS: A COMPUTATIONAL TOOL FOR MODELING AND PREDICTING PROTEASE SPECIFICITY Academic Article
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Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits Academic Article
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Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite Academic Article
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Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC Academic Article
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Progranulin does not inhibit TNF and lymphotoxin-signalling through TNF receptor 1 Academic Article
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Protein kinase C and downstream signaling pathways in a three-dimensional model of phorbol ester-induced angiogenesis Academic Article
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Proton pump inhibitors, genetic polymorphisms and response to clopidogrel therapy Academic Article
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RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL Academic Article
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ROLE OF p38-MITOGEN-ACTIVATED PROTEIN KINASE IN ISCHAEMIC PRECONDITIONING IN RAT HEART Academic Article
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Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation Academic Article
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Regulation of Enterocyte Apoptosis by Acyl-CoA Synthetase 5 Splicing Academic Article
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Regulation of Raf-1 activation and signalling by dephosphorylation Academic Article
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Regulation of alternative oxidase activity in higher plants Academic Article
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Requirements for proteolysis during apoptosis. Academic Article
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Scabies Mite Inactivated Serine Protease Paralogs Inhibit the Human Complement System Academic Article
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Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo Academic Article
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Short-chain fatty acids reduce expression of specific protein kinase C isoforms in human colonic epithelial cells Academic Article
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Signalling pathways activated by hydrogen peroxide in vascular smooth muscle Academic Article
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Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization Academic Article
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Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI Academic Article
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Structural Mechanisms of Inactivation in Scabies Mite Serine Protease Paralogues Academic Article
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Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates Academic Article
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TRAIL Induces Receptor-Interacting Protein 1–Dependent and Caspase-Dependent Necrosis-Like Cell Death under Acidic Extracellular Conditions Academic Article
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The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast Academic Article
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The Elusive Role of the Potential Factor X Cation-binding Exosite-1 in Substrate and Inhibitor Interactions Academic Article
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The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury Academic Article
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The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation Academic Article
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The Phytocalpain Defective Kernel 1 Is a Novel Arabidopsis Growth Regulator Whose Activity Is Regulated by Proteolytic Processing Academic Article
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The Plasticity of Oncogene Addiction: Implications for Targeted Therapies Directed to Receptor Tyrosine Kinases Academic Article
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The Soluble Guanylyl Cyclase Activator Bay 58-2667 Selectively Limits Cardiomyocyte Hypertrophy Academic Article
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The UBA domain of SnRK1 promotes activation and maintains catalytic activity Academic Article
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The X-ray Crystal Structure of Full-Length Human Plasminogen Academic Article
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The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome Academic Article
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The molecular biology of apoptosis. Academic Article
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Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins Academic Article
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Ultramarine, a Chromoprotein Acceptor for Förster Resonance Energy Transfer Academic Article
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Unraveling the Redox Properties of the Global Regulator FurA from Anabaena sp PCC 7120: Disulfide Reductase Activity Based on Its CXXC Motifs Academic Article
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Untying the regulation of the Raf-1 kinase Academic Article
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X-ray Induced Activity of N-Ethylmaleimide-Sensitive DNA Polymerase in Chinese Hamster Cells Academic Article
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XIAP discriminates between type I and type II FAS-induced apoptosis Academic Article
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cdc25 M-phase Inducer Academic Article
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gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways Academic Article