subject area of

• A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1  Academic Article
• Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism  Academic Article
• Antagonism of IAPs enhances CAR T-cell efficacy  Academic Article
• Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells  Academic Article
• Asymmetric Recruitment of cIAPs by TRAF2  Academic Article
• Bioenergetic differences selectively sensitize tumorigenic liver progenitor cells to a new gold(I) compound  Academic Article
• CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.  Academic Article
• Caspase inhibitors  Academic Article
• Caspase inhibitors: viral, cellular and chemical  Academic Article
• Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7  Academic Article
• Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment  Academic Article
• Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Can Regulate E2F1 Transcription Factor-mediated Control of Cyclin Transcription  Academic Article
• Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus  Academic Article
• Characterization of the DrosophilaCaspase, DAMM  Academic Article
• Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.  Academic Article
• Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways  Academic Article
• DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues  Academic Article
• Debcl, a Proapoptotic Bcl-2 Homologue, Is a Component of the Drosophila melanogaster Cell Death Machinery  Academic Article
• Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response  Academic Article
• Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance  Academic Article
• Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP  Academic Article
• E2F1 Binds to the Peptide-Binding Groove within the BIR3 Domain of cIAP1 and Requires cIAP1 for Chromatin Binding  Academic Article
• Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis  Academic Article
• HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins  Academic Article
• HtrA2/Omi, a Sheep in Wolf's Clothing  Academic Article
• IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis  Academic Article
• IAP Family of Cell Death and Signaling Regulators  Chapter
• IAP antagonists sensitize murine osteosarcoma cells to killing by TNF alpha  Academic Article
• IAP et Rho : enfin connectées  Academic Article
• IAP gene deletion and conditional knockout models  Academic Article
• IAPS and ubiquitylation  Academic Article
• IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans  Academic Article
• IAPs and cell death  Chapter
• IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis  Academic Article
• IAPs limit activation of RIP kinases by TNF receptor 1 during development  Academic Article
• IAPs – the ubiquitin connection  Academic Article
• IAPs, RINGs and ubiquitylation  Academic Article
• IAPs, TNF, inflammation and Jürg TSCHOPP; A personal perspective  Academic Article
• Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach  Academic Article
• Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins  Academic Article
• Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs  Academic Article
• In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8*  Academic Article
• Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells  Academic Article
• Inhibition of interleukin 1 -converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP  Conference Paper
• Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation  Academic Article
• Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation  Academic Article
• Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation  Academic Article
• Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy  Academic Article
• Inhibitor of apoptosis protein-1 regulates tumor necrosis factor-mediated destruction of intestinal epithelial cells  Academic Article
• Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs  Academic Article
• Killing Lymphoma with Smac-Mimetics: As Easy as ABC?  Academic Article
• Les IAP au cœur de la signalisation NF-κB  Academic Article
• Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms  Academic Article
• MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication  Academic Article
• Mammalian mitochondrial IAP binding proteins  Academic Article
• Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2  Academic Article
• More Than Cell Death  Academic Article
• NF-κB Inhibition Reveals Differential Mechanisms of TNF Versus TRAIL-Induced Apoptosis Upstream or at the Level of Caspase-8 Activation Independent of cIAP2  Academic Article
• New Perspectives in TNF-R1-Induced NF-kappa B Signaling  Conference Paper
• PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF  Academic Article
• RIP-in CD95-induced cell death: The control of alternative death receptors pathways by cIAPs  Academic Article
• RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL  Academic Article
• Recent advances in understanding inhibitor of apoptosis proteins  Academic Article
• Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction  Academic Article
• Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs  Academic Article
• Response to Heard et al  Academic Article
• STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2  Academic Article
• Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization  Academic Article
• Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat  Academic Article
• Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment  Academic Article
• Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype  Academic Article
• Systematic In Vivo RNAi Analysis Identifies IAPs as NEDD8-E3 Ligases  Academic Article
• TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis  Academic Article
• TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα  Academic Article
• The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID  Academic Article
• The Drosophila caspase DRONC is a glutamate/aspartate protease whose activity is regulated by DIAP1, HID and GRIM  Academic Article
• The Drosophila caspase DRONC is regulated by DIAP1  Academic Article
• The Survivin-like C. elegans BIR-1 Protein Acts with the Aurora-like Kinase AIR-2 to Affect Chromosomes and the Spindle Midzone  Academic Article
• Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding  Academic Article
• Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2  Academic Article
• Workshop Summary: Novel Aspects of the Functions of the TRAFs and cIAPs  Conference Paper
• XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation  Academic Article
• XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland  Academic Article
• cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation  Academic Article
• cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner  Academic Article