subject area of

• A class of highly selective inhibitors bind to an active state of PI3K gamma  Academic Article
• Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal  Academic Article
• Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity  Academic Article
• Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2  Academic Article
• Are we ready to restrict EGFR therapy to quadruple-negative colorectal cancer?  Academic Article
• CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers  Academic Article
• Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma  Academic Article
• Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase-Dependent Pathway That Is Impaired With Obesity  Academic Article
• Combined Blockade of ADP Receptors and PI3-Kinase p110β Fully Prevents Platelet and Leukocyte Activation during Hypothermic Extracorporeal Circulation  Academic Article
• Correlation of extended RAS and PIK3CA gene mutation status with outcomes from the phase III AGITG MAX STUDY involving capecitabine alone or in combination with bevacizumab plus or minus mitomycin C in advanced colorectal cancer  Academic Article
• Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity  Academic Article
• Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression  Academic Article
• Differential Protein Phosphorylation in 3T3-L1 Adipocytes in Response to InsulinVersusPlatelet-derived Growth Factor  Academic Article
• Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion  Academic Article
• Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3',4'-dihydroxyflavonol  Academic Article
• Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML  Academic Article
• Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?  Academic Article
• Flow-Induced Cerebral Vasodilatation in Vivo Involves Activation of Phosphatidylinositol-3 Kinase, NADPH-Oxidase, and Nitric Oxide Synthase  Academic Article
• Germline-activating mutations in PIK3CD compromise B cell development and function  Academic Article
• Growth restriction in the rat alters expression of cardiac JAK/STAT genes in a sex-specific manner  Academic Article
• HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer  Academic Article
• Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/PE40 ligand toxin in human breast cancer cells  Academic Article
• High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer  Academic Article
• Hypoxia Enhances the Proliferative Response of Macrophages to CSF-1 and Their Pro-Survival Response to TNF  Academic Article
• Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma  Academic Article
• Importance of phosphoinositide binding by human beta-defensin 3 for Akt-dependent cytokine induction  Academic Article
• Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells  Academic Article
• Insulin and Oleate Promote Translocation of Inosine-5′ Monophosphate Dehydrogenase to Lipid Bodies  Academic Article
• Insulin mediated activation of PI3K/Akt signalling pathway modifies the proteomic cargo of extracellular vesicles  Academic Article
• Interaction with PI3-kinase contributes to the cytotoxic activity of Apoptin  Academic Article
• Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1  Academic Article
• K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines  Academic Article
• Mammary Gland Remodeling Depends on gp130 Signaling through Stat3 and MAPK  Academic Article
• Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity  Academic Article
• Novel benzoxazines as inhibitors of angiogenesis  Academic Article
• OncogenicK-RASIs Required to Maintain Changes in Cytoskeletal Organization, Adhesion, and Motility in Colon Cancer Cells  Academic Article
• Opposing Roles of Endothelial and Smooth Muscle Phosphatidylinositol 3-Kinase in Vasoconstriction: Effects of Rho-Kinase and Hypertension  Academic Article
• Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase  Academic Article
• PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues  Academic Article
• PGRMC1 Phosphorylation Affects Cell Shape, Motility, Glycolysis, Mitochondrial Form and Function, and Tumor Growth  Academic Article
• PI 3-kinase p110β: a new target for antithrombotic therapy  Academic Article
• PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model  Academic Article
• PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab  Academic Article
• PIK3CA mutations are frequently observed in BRCAX but not BRCA2 -associated male breast cancer  Academic Article
• PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer  Academic Article
• Physiological Levels of Pik3ca(H1047R) Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ER alpha-Positive Tumors  Academic Article
• Physiological expression of the PI3K-activating mutation Pik3ca H1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice  Academic Article
• Potent Inhibitors of Phosphatidylinositol 3 (PI3) Kinase that have Antiproliferative Activity Only When Delivered as Prodrug Forms  Academic Article
• Relationship Between Colorectal Cancer Biomarkers and Response to Epidermal Growth Factor Receptor Monoclonal Antibodies  Academic Article
• Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents  Academic Article
• Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse  Academic Article
• Role of mitogen-activated protein kinase pathway in acetylcholine-mediated in vitro relaxation of rat pulmonary artery  Academic Article
• SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation  Academic Article
• Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation  Academic Article
• Selective inhibition of the platelet phosphoinositide 3-kinase p110β as promising new strategy for platelet protection during extracorporeal circulation  Academic Article
• Specific inhibition of PI3K p110δ inhibits CSF-1-induced macrophage spreading and invasive capacity  Conference Paper
• Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue  Academic Article
• Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin  Academic Article
• Strategies for Overcoming Inherent and Acquired Resistance to EGFR Inhibitors by Targeting Downstream Effectors in the RAS/PI3K Pathway  Academic Article
• Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[ e ][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation  Academic Article
• Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity  Academic Article
• Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines  Academic Article
• Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines  Academic Article
• Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8-and 6-aryl-substituted-1-3-benzoxazines  Academic Article
• Synthesis, structure elucidation, DNA-PK, PI3K, anti-platelet and anti-bacteria activity of linear 5, 6, and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3, 4, 6-substituted-8-morpholino-chromen-oxazine-2,10-dione  Academic Article
• TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT  Academic Article
• Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer  Academic Article
• Telomerase down-regulation does not mediate PC12 pheochromocytoma cell differentiation induced by NGF, but requires MAP kinase signalling  Academic Article
• The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function  Academic Article
• Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling  Academic Article
• β-Catenin/Tcf-4 Inhibition After Progastrin Targeting Reduces Growth and Drives Differentiation of Intestinal Tumors  Academic Article