Phosphatidylinositol 3-Kinases
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A class of highly selective inhibitors bind to an active state of PI3K gamma Academic Article
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Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal Academic Article
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Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity Academic Article
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Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2 Academic Article
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Are we ready to restrict EGFR therapy to quadruple-negative colorectal cancer? Academic Article
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CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers Academic Article
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Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma Academic Article
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Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase-Dependent Pathway That Is Impaired With Obesity Academic Article
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Combined Blockade of ADP Receptors and PI3-Kinase p110β Fully Prevents Platelet and Leukocyte Activation during Hypothermic Extracorporeal Circulation Academic Article
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Correlation of extended RAS and PIK3CA gene mutation status with outcomes from the phase III AGITG MAX STUDY involving capecitabine alone or in combination with bevacizumab plus or minus mitomycin C in advanced colorectal cancer Academic Article
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Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity Academic Article
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Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression Academic Article
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Differential Protein Phosphorylation in 3T3-L1 Adipocytes in Response to InsulinVersusPlatelet-derived Growth Factor Academic Article
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Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion Academic Article
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Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3',4'-dihydroxyflavonol Academic Article
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Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML Academic Article
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Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic? Academic Article
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Flow-Induced Cerebral Vasodilatation in Vivo Involves Activation of Phosphatidylinositol-3 Kinase, NADPH-Oxidase, and Nitric Oxide Synthase Academic Article
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Germline-activating mutations in PIK3CD compromise B cell development and function Academic Article
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Growth restriction in the rat alters expression of cardiac JAK/STAT genes in a sex-specific manner Academic Article
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HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer Academic Article
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Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/PE40 ligand toxin in human breast cancer cells Academic Article
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High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer Academic Article
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Hypoxia Enhances the Proliferative Response of Macrophages to CSF-1 and Their Pro-Survival Response to TNF Academic Article
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Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma Academic Article
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Importance of phosphoinositide binding by human beta-defensin 3 for Akt-dependent cytokine induction Academic Article
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Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells Academic Article
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Insulin and Oleate Promote Translocation of Inosine-5′ Monophosphate Dehydrogenase to Lipid Bodies Academic Article
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Insulin mediated activation of PI3K/Akt signalling pathway modifies the proteomic cargo of extracellular vesicles Academic Article
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Interaction with PI3-kinase contributes to the cytotoxic activity of Apoptin Academic Article
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Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1 Academic Article
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K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines Academic Article
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Mammary Gland Remodeling Depends on gp130 Signaling through Stat3 and MAPK Academic Article
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Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity Academic Article
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Novel benzoxazines as inhibitors of angiogenesis Academic Article
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OncogenicK-RASIs Required to Maintain Changes in Cytoskeletal Organization, Adhesion, and Motility in Colon Cancer Cells Academic Article
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Opposing Roles of Endothelial and Smooth Muscle Phosphatidylinositol 3-Kinase in Vasoconstriction: Effects of Rho-Kinase and Hypertension Academic Article
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Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase Academic Article
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PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues Academic Article
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PGRMC1 Phosphorylation Affects Cell Shape, Motility, Glycolysis, Mitochondrial Form and Function, and Tumor Growth Academic Article
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PI 3-kinase p110β: a new target for antithrombotic therapy Academic Article
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PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model Academic Article
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PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab Academic Article
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PIK3CA mutations are frequently observed in BRCAX but not BRCA2 -associated male breast cancer Academic Article
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PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer Academic Article
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Physiological Levels of Pik3ca(H1047R) Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ER alpha-Positive Tumors Academic Article
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Physiological expression of the PI3K-activating mutation Pik3ca H1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice Academic Article
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Potent Inhibitors of Phosphatidylinositol 3 (PI3) Kinase that have Antiproliferative Activity Only When Delivered as Prodrug Forms Academic Article
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Relationship Between Colorectal Cancer Biomarkers and Response to Epidermal Growth Factor Receptor Monoclonal Antibodies Academic Article
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Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents Academic Article
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Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse Academic Article
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Role of mitogen-activated protein kinase pathway in acetylcholine-mediated in vitro relaxation of rat pulmonary artery Academic Article
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SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation Academic Article
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Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation Academic Article
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Selective inhibition of the platelet phosphoinositide 3-kinase p110β as promising new strategy for platelet protection during extracorporeal circulation Academic Article
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Specific inhibition of PI3K p110δ inhibits CSF-1-induced macrophage spreading and invasive capacity Conference Paper
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Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue Academic Article
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Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin Academic Article
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Strategies for Overcoming Inherent and Acquired Resistance to EGFR Inhibitors by Targeting Downstream Effectors in the RAS/PI3K Pathway Academic Article
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Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[ e ][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation Academic Article
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Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity Academic Article
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Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines Academic Article
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Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines Academic Article
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Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8-and 6-aryl-substituted-1-3-benzoxazines Academic Article
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Synthesis, structure elucidation, DNA-PK, PI3K, anti-platelet and anti-bacteria activity of linear 5, 6, and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3, 4, 6-substituted-8-morpholino-chromen-oxazine-2,10-dione Academic Article
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TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT Academic Article
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Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer Academic Article
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Telomerase down-regulation does not mediate PC12 pheochromocytoma cell differentiation induced by NGF, but requires MAP kinase signalling Academic Article
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The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function Academic Article
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Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling Academic Article
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β-Catenin/Tcf-4 Inhibition After Progastrin Targeting Reduces Growth and Drives Differentiation of Intestinal Tumors Academic Article