subject area of

• (α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xLRecognition:  Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions  Academic Article
• A 22-mer Segment in the Structurally Pliable Regulatory Domain of Metazoan CTP: Phosphocholine Cytidylyltransferase Facilitates Both Silencing and Activating Functions  Academic Article
• A Common Fold Mediates Vertebrate Defense and Bacterial Attack  Academic Article
• A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4  Academic Article
• A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor  Academic Article
• A Structural Investigation of NRZ Mediated Apoptosis Regulation in Zebrafish  Academic Article
• A Structural Model for Apolipoprotein C-II Amyloid Fibrils: Experimental Characterization and Molecular Dynamics Simulations  Academic Article
• A Toxic Conformer of Aβ42 with a Turn at 22–23 is a Novel Therapeutic Target for Alzheimer’s Disease  Academic Article
• A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR  Academic Article
• A mortise-tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes.  Academic Article
• A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein  Academic Article
• A partially structured region of a largely unstructured protein,Plasmodium falciparummerozoite surface protein 2 (MSP2), forms amyloid-like fibrils  Academic Article
• A radish seed antifungal peptide with a high amyloid fibril-forming propensity  Academic Article
• A structural characterization of the isoniazid Mycobacterium tuberculosis drug target, Rv2971, in its unliganded form.  Academic Article
• A suite of Switch i and Switch II mutant structures from the G-protein domain of FeoB  Academic Article
• Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death  Academic Article
• Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans  Academic Article
• An FcγRIIa-binding peptide that mimics the interaction between FcγRIIa and IgG  Academic Article
• Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1–P4 specificity reveals an unusual preference  Academic Article
• Analysis of PrP conformation using circular dichroism.  Academic Article
• Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus  Academic Article
• Anionic Phospholipid Interactions of the Prion Protein N Terminus Are Minimally Perturbing and Not Driven Solely by the Octapeptide Repeat Domain  Academic Article
• Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane  Academic Article
• Architecture of Eph receptor clusters  Academic Article
• Aromatic Anchor at an Invariant Hormone-Receptor Interface FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN  Academic Article
• Aromatic residues in the C-terminal helix of human apoC-I mediate phospholipid interactions and particle morphology  Academic Article
• Assignment of ¹H, ¹³C and ¹⁵N resonances of domain III of the ectodomain of apical membrane antigen 1 from Plasmodium falciparum [5]  Academic Article
• Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser  Academic Article
• Bicarbonate-Mediated Stimulation of RegA, the Global Virulence Regulator from Citrobacter rodentium  Academic Article
• Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization  Academic Article
• Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1  Academic Article
• Bioinformatic approaches for predicting substrates of proteases  Academic Article
• Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions  Academic Article
• CR1/CR2 Interactions Modulate the Functions of the Cell Surface Epidermal Growth Factor Receptor  Academic Article
• Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function  Academic Article
• Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling  Academic Article
• Can cyclic HIV protease inhibitors bind in a non-preferred form? An ab initio, DFT and MM-PB(GB)SA study  Academic Article
• Changes in snoRNA and snRNA Abundance in the Human, Chimpanzee, Macaque, and Mouse Brain  Academic Article
• Chaperonin 60 and mitochondrial disease in Dictyostelium  Academic Article
• Characterization of TCTP, the Translationally Controlled Tumor Protein, from Arabidopsis thaliana  Academic Article
• Characterization of bovine heparin-binding neurotrophic factor (HBNF): Assignment of disulfide bonds  Academic Article
• Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization  Academic Article
• Cleaved antitrypsin polymers at atomic resolution  Academic Article
• Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes  Academic Article
• Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer  Academic Article
• Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence  Academic Article
• Conservation of structural motifs and antigenic diversity in the Plasmodium falciparum merozoite surface protein-3 (MSP-3)1Note: Nucleotide sequence data reported in this manuscript are available in the EMBL, GenBank™ and DDJB data bases under the accession numbers L07944, L28825, U08851 and U08852.1  Academic Article
• Conserved Disruptions in the Predicted Coiled-Coil Domains of Eukaryotic SMC Complexes: Implications for Structure and Function  Academic Article
• CopC Protein fromPseudomonassyringae:  Intermolecular Transfer of Copper from Both the Copper(I) and Copper(II) Sites  Academic Article
• Copper and Zinc Binding Modulates the Aggregation and Neurotoxic Properties of the Prion Peptide PrP106−126†  Academic Article
• Crystal Structure and Comparative Functional Analyses of a Mycobacterium Aldo-Keto Reductase  Academic Article
• Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins  Academic Article
• Crystal structure and immunological properties of the first annexin fromSchistosoma mansoni: insights into the structural integrity of the schistosomal tegument  Academic Article
• Crystal structure of auracyanin, a “blue” copper protein from the green thermophilic photosynthetic bacterium Chloroflexus aurantiacus11Edited by R Huber  Academic Article
• Crystal structure of theLeishmania majorMIX protein: A scaffold protein that mediates protein-protein interactions  Academic Article
• Delineating common molecular mechanisms in Alzheimer's and prion diseases  Academic Article
• Design principles of peptide based self-assembled nanomaterials  Chapter
• Dimerization of Bacterial Diaminopimelate Epimerase Is Essential for Catalysis  Academic Article
• Diverse functions of mitochondrial AAA+ proteins: protein activation, disaggregation, and degradationThis paper is one of a selection of papers published in this special issue entitled 8th International Conference on AAA Proteins and has undergone the Journal's usual peer review process.  Academic Article
• Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of α-Synuclein in a pH-Dependent Manner  Academic Article
• Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway  Academic Article
• EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2  Academic Article
• EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit.  Academic Article
• Effect of Oxidation and Mutation on the Conformational Dynamics and Fibril Assembly of Amyloidogenic Peptides Derived from Apolipoprotein C-II  Academic Article
• Effect of pH and denaturants on the folding and stability of murine interleukin-6  Academic Article
• Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain  Academic Article
• Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 from Arabidopsis thaliana  Academic Article
• Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein†  Academic Article
• Functional implications of modifying RyR-activating peptides for membrane permeability  Academic Article
• GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop  Academic Article
• Generating recombinant C-terminal prion protein fragments of exact native sequence  Academic Article
• Geometrically Precise Building Blocks: the Self-Assembly of beta-Peptides  Academic Article
• Glycosaminoglycan sulfation determines the biochemical properties of prion protein aggregates  Academic Article
• High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL  Academic Article
• Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain  Academic Article
• How insulin engages its primary binding site on the insulin receptor  Academic Article
• Human Erythrocyte Band 7.2b Is Preferentially Labeled by a Photoreactive Phospholipid  Academic Article
• ILQINS Hexapeptide, Identified in Lysozyme Left-Handed Helical Ribbons and Nanotubes, Forms Right-Handed Helical Ribbons and Crystals  Academic Article
• Identification of Active-Site Residues of the Pro-Metastatic Endoglycosidase Heparanase†  Academic Article
• Identification of an amyloid fibril forming peptide comprising residues 46-59 of apolipoprotein A-I  Academic Article
• Identification of the bona fide DHDPS from a common plant pathogen  Academic Article
• Import-Associated Translational Inhibition: Novel In Vivo Evidence for Cotranslational Protein Import intoDictyostelium discoideumMitochondria  Academic Article
• Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 fromPlasmodium falciparum  Academic Article
• Interleukin-6: Structure-function relationships  Academic Article
• Intracellular Trafficking of the KV1.3 Potassium Channel Is Regulated by the Prodomain of a Matrix Metalloprotease  Academic Article
• Introduction of a Mutation in the Shutter Region of Antithrombin (Phe77 → Leu) Increases Affinity for Heparin and Decreases Thermal Stability†  Academic Article
• Kinetic and Structural Analysis of MutantEscherichia coliDihydroorotases:  A Flexible Loop Stabilizes the Transition State†,‡  Academic Article
• Lactam-Stabilized Helical Analogues of the Analgesic μ-Conotoxin KIIIA  Academic Article
• Ligand Recognition by the TPR Domain of the Import Factor Toc64 from Arabidopsis thaliana  Academic Article
• Mapping a conserved conformational epitope from the M protein of group a streptococci  Academic Article
• Mechanism of Membrane Interaction and Disruption by α-Synuclein  Academic Article
• Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases  Academic Article
• Membrane core-specific antimicrobial action of Cathelicidin LL-37 peptide switches between pore and nanofibre formation  Academic Article
• Methods to Measure the Kinetics of Protease Inhibition by Serpins  Academic Article
• Microsatellites grant more stable flanking genes  Academic Article
• Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1  Academic Article
• Modelling the structure of the fusion protein from human respiratory syncytial virus  Academic Article
• Molecular cloning of a gene encoding an arabinogalactan-protein from pear (Pyrus communis) cell suspension culture.  Academic Article
• Mutation to bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis  Academic Article
• Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop  Academic Article
• New method for purifying histidine-rich glycoprotein from human plasma redefines its functional properties  Academic Article
• Novel insights on the mechanism of action of α-amylase inhibitors from the plant defensin family  Academic Article
• O-Glycosylated Cell Wall Proteins Are Essential in Root Hair Growth  Academic Article
• Phospholipid Interaction Induces Molecular-level Polymorphism in Apolipoprotein C-II Amyloid Fibrils via Alternative Assembly Pathways  Academic Article
• Physical characterization of serpin conformations  Academic Article
• Physicochemical Characterization of an Antagonistic Human Interleukin-6 Dimer†  Academic Article
• PinA from Aspergillus nidulans binds to pS/pT-P motifs using the same Loop I and XP groove as mammalian Pin1  Academic Article
• Pollen Tubes of Nicotiana alata Express Two Genes from Different β-Glucan Synthase Families  Academic Article
• Polyalanine expansions drive a shift into alpha-helical clusters without amyloid-fibril formation  Academic Article
• Predicting serpin/protease interactions  Academic Article
• Preprotein Translocase of the Outer Mitochondrial Membrane: Reconstituted Tom40 Forms a Characteristic TOM Pore  Academic Article
• Probing the structure of Leishmania major DHFR TS and structure based virtual screening of peptide library for the identification of anti-leishmanial leads  Academic Article
• Properties of the Thioredoxin Fold Superfamily Are Modulated by a Single Amino Acid Residue  Academic Article
• Protein unfolding is essential for cleavage within the alpha-helix of a model protein substrate by the serine protease, thrombin  Academic Article
• Relaxin-like bioactivity of ovine Insulin 3 (INSL3) analogues  Academic Article
• Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5  Academic Article
• Research on the Tomato Metacaspase Protein Interactions with Ca~2＋ by Spectroscopy and Molecular Probe  Academic Article
• Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics  Academic Article
• Reversible Conversion of Monomeric Human Prion Protein Between Native and Fibrilogenic Conformations  Academic Article
• Rv2969c, essential for optimal growth inMycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases  Academic Article
• Selective Removal of Individual Disulfide Bonds within a Potato Type II Serine Proteinase Inhibitor from Nicotiana alata Reveals Differential Stabilization of the Reactive-Site Loop  Academic Article
• Sent packing: Protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility  Academic Article
• Serpins 2005 - fun between the β-sheets  Academic Article
• Serpins in theCaenorhabditis elegans genome  Academic Article
• Serpins: Finely Balanced Conformational Traps  Academic Article
• Signals Required for the Import and Processing of the Alternative Oxidase into Mitochondria  Academic Article
• Solution Conformation, Backbone Dynamics and Lipid Interactions of the Intrinsically Unstructured Malaria Surface Protein MSP2  Academic Article
• Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat  Academic Article
• Solution structure of synthetic peptides corresponding to the C-terminal helix of interleukin-6  Academic Article
• Solution structures by 1 H NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant 1 1Edited by M. F. Summers  Academic Article
• Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity  Academic Article
• Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design  Academic Article
• Structural Refinement of Insecticidal Plant Proteinase Inhibitors from Nicotiana alata  Academic Article
• Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 fromNeisseria meningitidis  Academic Article
• Structural and Biological Characterization of Murine-Human Interleukin-6 Chimeras  Conference Paper
• Structural and Functional Characterization of Three DsbA Paralogues fromSalmonella entericaSerovar Typhimurium  Academic Article
• Structural biology of the Bcl-2 family and its mimicry by viral proteins  Academic Article
• Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria  Academic Article
• Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists  Academic Article
• Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition  Academic Article
• Structure and Function of DsbA, a Key Bacterial Oxidative Folding Catalyst  Academic Article
• Structure and Inter-domain Interactions of Domain II from the Blood-stage Malarial Protein, Apical Membrane Antigen 1  Academic Article
• Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis  Academic Article
• Structure of the Analgesic μ-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion†‡  Academic Article
• Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1  Academic Article
• Structure ofEscherichia coliaminopeptidase P in complex with the inhibitor apstatin  Academic Article
• Structure ofPetunia hybridaDefensin 1, a Novel Plant Defensin with Five Disulfide Bonds†  Academic Article
• Synthesis and Structure Determination by NMR of a Putative Vacuolar Targeting Peptide and Model of a Proteinase Inhibitor fromNicotiana alata†,‖  Academic Article
• Synthesis of Stapled β3-Peptides through Ring-Closing Metathesis  Academic Article
• Targeted Delivery of an ssrA-Tagged Substrate by the Adaptor Protein SspB to Its Cognate AAA+ Protein ClpX  Academic Article
• The BECN1 N-terminal domain is intrinsically disordered  Academic Article
• The Disulfide Bond Arrangement of Leukemia Inhibitory Factor: Homology to Oncostatin M and Structural Implications  Academic Article
• The High Resolution Crystal Structure of the Human Tumor Suppressor Maspin Reveals a Novel Conformational Switch in the G-helix  Academic Article
• The Interaction of Bioactive Peptides with an Immobilized Phosphatidylcholine Monolayer  Academic Article
• The Murine Orthologue of Human Antichymotrypsin  Academic Article
• The Propeptide of the Transforming Growth Factor-β Superfamily Member, Macrophage Inhibitory Cytokine-1 (MIC-1), Is a Multifunctional Domain That Can Facilitate Protein Folding and Secretion  Academic Article
• The Single Mutation Phe173 → Ala Induces a Molten Globule-like State in Murine Interleukin-6†  Academic Article
• The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability  Academic Article
• The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4  Academic Article
• The Three-dimensional Solution Structure by 1H NMR of a 6-Kda Proteinase Inhibitor Isolated from the Stigma of Nicotiana alata  Academic Article
• The WD40 Protein BamB Mediates Coupling of BAM Complexes into Assembly Precincts in the Bacterial Outer Membrane  Academic Article
• The X-ray Crystal Structure of Full-Length Human Plasminogen  Academic Article
• The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping  Academic Article
• The defensins consist of two independent, convergent protein superfamilies  Academic Article
• The role of strand 1 of the C β-sheet in the structure and function of α1-antitrypsin  Academic Article
• The solution structure of C1-T1, a two-domain proteinase inhibitor derived from a circular precursor protein from Nicotiana alata11Edited by P. E. Wright  Academic Article
• The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha-helical dihydropyridine receptor segment  Academic Article
• The trans-Golgi network GRIP-domain proteins form α-helical homodimers  Academic Article
• Trifluoroethanol induces the self-association of specific amphipathic peptides  Academic Article
• Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules  Academic Article
• Unzipping the role of chirality in nanoscale self-assembly of tripeptide hydrogels  Academic Article