subject area of

• A Multicenter Blinded Study to Evaluate KRAS Mutation Testing Methodologies in the Clinical Setting  Academic Article
• A comparative study of the phenotype and proliferative capacity of peripheral blood (PB) CD34⁺cells mobilized by four different protocols and those of steady-phase PB and bone marrow CD34⁺cells  Academic Article
• A frequent HindIII RFLP on chromosome 3p21–25 detected by a genomicerbAβ sequence  Academic Article
• A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation  Academic Article
• A novel myb -related gene from Arabidopsis thaliana  Academic Article
• A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo [letter]  Academic Article
• ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer  Academic Article
• APOPTOSIS: A Cinderella Caspase Takes Center Stage  Academic Article
• Ablation of Tumor Progression Locus 2 Promotes a Type 2 Th Cell Response in Ovalbumin-Immunized Mice  Academic Article
• Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice  Conference Paper
• Accommodating haploinsufficient tumour suppressor genes in Knudson's model  Academic Article
• Activation of physiological cell death mechanisms by a necrosis-causing agent  Academic Article
• Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation  Academic Article
• Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice  Academic Article
• Alternative splicing of Bim and Erk-mediated Bim EL phosphorylation are dispensable for hematopoietic homeostasis in vivo  Academic Article
• Analysis of Grb7 Recruitment by Heregulin-activated erbB Receptors Reveals a Novel Target Selectivity for erbB3  Academic Article
• Analysis of the Role of bcl-2 in Apoptosis  Academic Article
• Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma  Academic Article
• Anti-apoptotic gene Bcl2 is required for stapes development and hearing  Academic Article
• Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak  Academic Article
• Apoptosis: A sticky business  Academic Article
• Association of hypomagnesemia with inferior survival in a phase III, randomized study of cetuximab plus best supportive care versus best supportive care alone: NCIC CTG/AGITG CO.17  Academic Article
• BH3-Only proteins in health and disease  Chapter
• BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes  Academic Article
• BH3-only proteins: the thorny end of the ER stress response  Academic Article
• BRAF inhibitor-driven tumor proliferation in akras-mutated colon carcinoma is not overcome by mek1/2 inhibition  Academic Article
• Bcl-2 and thermotolerance cooperate in cell survival  Academic Article
• Bcl-2, Bcl-x L, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells  Academic Article
• Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax  Academic Article
• Bim Links ER Stress and Apoptosis in Cells Expressing Mutant SOD1 Associated with Amyotrophic Lateral Sclerosis  Academic Article
• Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic  Academic Article
• Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression  Comment
• Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis  Academic Article
• Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199  Academic Article
• CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13  Academic Article
• CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)−mediated apoptosis  Academic Article
• Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma  Academic Article
• Cell death: Shadow Baxing  Academic Article
• Cellular Mechanisms Underlying Complete Hematological Response of Chronic Myeloid Leukemia to BRAF and MEK1/2 Inhibition in a Patient with Concomitant Metastatic Melanoma  Academic Article
• Cloning of Mouse RP-8 cDNA and Its Expression During Apoptosis of Lymphoid and Myeloid Cells  Academic Article
• Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands  Academic Article
• Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response  Academic Article
• Control of Apoptosis in Hematopoietic Cells by the Bcl-2 Family of Proteins  Conference Paper
• Controlling TRAIL-mediated caspase-3 activation  Academic Article
• Correlation of mutation status and survival with predominant histologic subtype according to the new IASLC/ATS/ERS lung adenocarcinoma classification in stage III (N2) patients  Academic Article
• Cost-Minimization Analysis of the Treatment of Patients With Metastatic Colorectal Cancer in Greece  Academic Article
• Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family  Academic Article
• Crystallization and preliminary X-ray characterization of Epstein–Barr virus BHRF1 in complex with a benzoylurea peptidomimetic  Academic Article
• Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim  Academic Article
• Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death  Academic Article
• Cytoplasmic p53 is not required for PUMA-induced apoptosis  Academic Article
• DR5 and caspase-8 are dispensable in ER stress-induced apoptosis  Academic Article
• Death in the snow: report on Keystone Conference on ‘Apoptosis and Programmed Cell Death’ at Breckenridge, CO, April 6–11th 1999  Conference Paper
• Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells  Academic Article
• Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function  Academic Article
• Differential requirement for OBF-1 during antibody-secreting cell differentiation  Academic Article
• Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes  Academic Article
• Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase  Academic Article
• Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer  Academic Article
• EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency  Academic Article
• ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim  Academic Article
• Early work on the function of Bcl-2, an interview with David Vaux  Academic Article
• Effect of a Selective Mas Receptor Agonist in Cerebral Ischemia In Vitro and In Vivo  Academic Article
• Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.  Academic Article
• Entamoeba histolytica: Target Cells Killed by Trophozoites Undergo DNA Fragmentation Which Is Not Blocked by Bcl-2  Academic Article
• Essential role for a novel population of binucleated mammary epithelial cells in lactation  Academic Article
• Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain  Academic Article
• Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA  Academic Article
• Expression of secreted frizzled-related protein 4 in the primate placenta  Academic Article
• Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim  Academic Article
• Fli-1 Is Required for Murine Vascular and Megakaryocytic Development and Is Hemizygously Deleted in Patients with Thrombocytopenia  Academic Article
• Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL  Academic Article
• Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells.  Academic Article
• Further Insights into the Effects of Pre-organizing the BimBH3 Helix [Addendum ]  Erratum
• Ganging up on Angiotensin II Type 1 Receptors in Vascular Remodeling  Academic Article
• Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics  Academic Article
• Genetic analysis of ETS genes in C. elegans  Academic Article
• Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer  Academic Article
• Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM  Academic Article
• Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/PE40 ligand toxin in human breast cancer cells  Academic Article
• High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies  Academic Article
• High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer  Academic Article
• Hoxb8 regulates expression of microRNAs to control cell death and differentiation  Academic Article
• Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1  Academic Article
• Human ERG is a proto-oncogene with mitogenic and transforming activity  Academic Article
• Immunologic competence of B cells subjected to constitutive c-myc oncogene expression in immunoglobulin heavy chain enhancer myc transgenic mice  Academic Article
• Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice  Academic Article
• Increased recruitment of hematopoietic progenitor cells underlies the ex vivo expansion potential of FLT3 ligand  Academic Article
• Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca 2+ /Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway  Academic Article
• Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1  Academic Article
• Investigating the Potential Role of Genetic and Epigenetic Variation of DNA Methyltransferase Genes in Hyperplastic Polyposis Syndrome  Academic Article
• Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells.  Academic Article
• Isolation of two novel myb-like genes from Arabidopsis and studies on the DNA-binding properties of their products  Academic Article
• Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins  Academic Article
• Limited copy number - high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies  Academic Article
• Limiting reductive stress for treating in-stent stenosis: the heart of the matter?  Academic Article
• Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands  Academic Article
• Localization of four human chromosome 21 genes—SOD1, ETS2, IFNAR, and CBR—to two different chromosomes in the marsupial species Macropus eugenii  Academic Article
• Loss of phosphatase and tensin homolog protein expression is an independent poor prognostic marker in lung adenocarcinoma  Academic Article
• Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells  Academic Article
• MDM4 is a rational target for treating breast cancers with mutant p53  Academic Article
• MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation  Academic Article
• Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine  Academic Article
• Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation  Academic Article
• MicroRNAs and lymphocyte homeostasis: Dangerous eggs in a single basket  Academic Article
• Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis  Academic Article
• Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1  Academic Article
• Molecular Cloning Reveals that the p160 Myb-Binding Protein Is a Novel, Predominantly Nucleolar Protein Which May Play a Role in Transactivation by Myb  Academic Article
• Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity  Academic Article
• Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2.  Academic Article
• Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan  Academic Article
• Optimisation of the RT-PCR detection of immunomagnetically enriched carcinoma cells  Academic Article
• Overexpression of multiple oncogenes related to histological grade of astrocytic glioma  Academic Article
• PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer  Academic Article
• PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain  Academic Article
• Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration  Academic Article
• Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2  Academic Article
• Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2  Academic Article
• Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation  Academic Article
• Prospective Cost-Effectiveness Analysis of Cetuximab in Metastatic Colorectal Cancer: Evaluation of National Cancer Institute of Canada Clinical Trials Group CO.17 Trial  Academic Article
• Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim  Academic Article
• RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas  Academic Article
• RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation  Academic Article
• ROS1 and ALK Fusions in Colorectal Cancer, with Evidence of Intratumoral Heterogeneity for Molecular Drivers  Academic Article
• ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study  Academic Article
• Randomized phase Ib/II trial of rilotumumab or ganitumab with panitumumab versus panitumumab alone in patients with wild-type KRAS metastatic colorectal cancer  Academic Article
• Rapid Selection against Truncation Mutants in Yeast Reverse Two-Hybrid Screens  Academic Article
• Relationship between M-BCR breakpoint position in blast crisis and length of chronic phase in chronic myeloid leukemia [5]  Academic Article
• Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics  Academic Article
• Role of p53 in the progression of gastric cancer  Academic Article
• SCL gene in human tumors  Academic Article
• SCL, the gene implicated in human T-cell leukaemia, is oncogenic in a murine T-lymphocyte cell line  Academic Article
• Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo  Academic Article
• Sensitive quantification of somatic mutations using molecular inversion probes  Academic Article
• Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue  Academic Article
• Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity  Academic Article
• Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from type 2 diabetes patients: Rescue by α-ketoglutarate and TET-TDG functional reactivation  Academic Article
• Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design  Academic Article
• Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L  Academic Article
• Structural insights into the degradation of Mcl-1 induced by BH3 domains  Academic Article
• Studies on the promoter of the Arabidopsis thaliana cdc2a gene  Academic Article
• TR3/Nur77 in colon cancer cell apoptosis  Academic Article
• Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer  Academic Article
• The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia  Academic Article
• The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast  Academic Article
• The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling  Academic Article
• The PKA paradox: Is Bim the answer?  Academic Article
• The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex  Academic Article
• The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger  Academic Article
• The Role of the Pro-Apoptotic Bcl-2 Family Member Bim in Physiological Cell Death  Conference Paper
• The Wnt Receptor Ryk Is Required for Wnt5a-Mediated Axon Guidance on the Contralateral Side of the Corpus Callosum  Academic Article
• The ability to form primary tumor xenografts is predictive of increased risk of disease recurrence in early-stage non-small cell lung cancer  Academic Article
• The c-myb negative regulatory domain  Conference Paper
• The clinical relevance of pathologic subtypes in metastatic lung adenocarcinoma  Academic Article
• The mobilization of primitive hemopoietic progenitors into the peripheral blood  Academic Article
• The mouse Plk gene: structural characterization, chromosomal localization and identification of a processed Plk pseudogene  Academic Article
• The purification of a Rap1 GTPase-activating protein from bovine brain cytosol  Academic Article
• The relationship between rash, tumour KRAS mutation status and clinical and quality of life outcomes in patients with advanced colorectal cancer treated with cetuximab in the NCIC CTG/AGITG CO.17  Academic Article
• The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist  Academic Article
• The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins  Academic Article
• The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system  Academic Article
• The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy  Academic Article
• The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation  Academic Article
• The transgenic window on lymphoid malignancy.  Academic Article
• Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer  Academic Article
• To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions  Academic Article
• Tpl2 kinase regulates T cell interferon-γ production and host resistance toToxoplasma gondii  Academic Article
• Transcription factor PU.1 promotes conventional dendritic cell identity and function via induction of transcriptional regulator DC-SCRIPT  Academic Article
• Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins  Academic Article
• Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1β Production  Academic Article
• Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim  Academic Article
• Vasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E–Deficient Mice  Academic Article
• alpha/beta-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells  Academic Article
• erba-related sequence coding for dna-binding hormone receptor localized to chromosome 3p21-3p25 and deleted in small cell lung carcinoma  Academic Article