Proto-Oncogene Proteins
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A Multicenter Blinded Study to Evaluate KRAS Mutation Testing Methodologies in the Clinical Setting Academic Article
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A Randomized Phase II/III Study of Dalotuzumab in Combination With Cetuximab and Irinotecan in Chemorefractory, KRAS Wild-Type, Metastatic Colorectal Cancer Academic Article
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A comparative study of the phenotype and proliferative capacity of peripheral blood (PB) CD34+ cells mobilized by four different protocols and those of steady-phase PB and bone marrow CD34+ cells Academic Article
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A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis Academic Article
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A frequent HindIII RFLP on chromosome 3p21–25 detected by a genomicerbAβ sequence Academic Article
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A niche-dependent myeloid transcriptome signature defines dormant myeloma cells Academic Article
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A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation Academic Article
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A novel myb
-related gene from Arabidopsis thaliana Academic Article
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A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo [letter] Academic Article
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APOPTOSIS: A Cinderella Caspase Takes Center Stage Academic Article
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Ablation of Tumor Progression Locus 2 Promotes a Type 2 Th Cell Response in Ovalbumin-Immunized Mice Academic Article
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Abnormalities of the Immune System Induced by Dysregulated bcl-2 Expression in Transgenic Mice Conference Paper
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Accommodating haploinsufficient tumour suppressor genes in Knudson's model Academic Article
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Activation of physiological cell death mechanisms by a necrosis-causing agent Academic Article
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Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation Academic Article
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Alternative splicing of Bim and Erk-mediated Bim EL phosphorylation are dispensable for hematopoietic homeostasis in vivo Academic Article
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Analysis of Grb7 Recruitment by Heregulin-activated erbB Receptors Reveals a Novel Target Selectivity for erbB3 Academic Article
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Analysis of the Role of bcl-2 in Apoptosis Academic Article
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Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma Academic Article
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Anti-apoptotic gene Bcl2 is required for stapes development and hearing Academic Article
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Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak Academic Article
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Apoptosis: A sticky business Academic Article
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Are we ready to restrict EGFR therapy to quadruple-negative colorectal cancer? Academic Article
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BH3-Only proteins in health and disease Chapter
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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes Academic Article
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BH3-only proteins: the thorny end of the ER stress response Academic Article
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BRAF inhibitor-driven tumor proliferation in akras-mutated colon carcinoma is not overcome by mek1/2 inhibition Academic Article
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Bcl-2 and thermotolerance cooperate in cell survival Academic Article
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Bcl-2, Bcl-x L, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells Academic Article
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Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax Academic Article
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Bim Links ER Stress and Apoptosis in Cells Expressing Mutant SOD1 Associated with Amyotrophic Lateral Sclerosis Academic Article
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Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic Academic Article
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Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression Comment
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Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis Academic Article
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Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199 Academic Article
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CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13 Academic Article
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CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)−mediated apoptosis Academic Article
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Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma Academic Article
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Cell death: Shadow Baxing Academic Article
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Cellular Mechanisms Underlying Complete Hematological Response of Chronic Myeloid Leukemia to BRAF and MEK1/2 Inhibition in a Patient with Concomitant Metastatic Melanoma Academic Article
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Cloning of Mouse RP-8 cDNA and Its Expression During Apoptosis of Lymphoid and Myeloid Cells Academic Article
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Colonic expression of c-myb is initiated in utero and continues throughout adult life Academic Article
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Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands Academic Article
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Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response Academic Article
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Control of Apoptosis in Hematopoietic Cells by the Bcl-2 Family of Proteins Conference Paper
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Controlling TRAIL-mediated caspase-3 activation Academic Article
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Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin Academic Article
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Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family Academic Article
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Crystallization and preliminary X-ray characterization of Epstein–Barr virus BHRF1 in complex with a benzoylurea peptidomimetic Academic Article
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Cyclic‐AMP‐dependent protein kinase A regulates apoptosis by stabilizing the BH3‐only protein Bim Academic Article
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Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death Academic Article
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Cytoplasmic p53 is not required for PUMA-induced apoptosis Academic Article
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DR5 and caspase-8 are dispensable in ER stress-induced apoptosis Academic Article
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Death in the snow: report on Keystone Conference on ‘Apoptosis and Programmed Cell Death’ at Breckenridge, CO, April 6–11th 1999 Conference Paper
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Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells Academic Article
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Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function Academic Article
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Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes Academic Article
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Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase Academic Article
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Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer Academic Article
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EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency Academic Article
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ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim Academic Article
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Early work on the function of Bcl-2, an interview with David Vaux Academic Article
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Effect of a Selective Mas Receptor Agonist in Cerebral Ischemia In Vitro and In Vivo Academic Article
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Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Academic Article
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Enhanced Acetaminophen Hepatotoxicity in Transgenic Mice Overexpressing BCL-2 Academic Article
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Entamoeba histolytica: Target Cells Killed by Trophozoites Undergo DNA Fragmentation Which Is Not Blocked by Bcl-2 Academic Article
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Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB Academic Article
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Essential role for a novel population of binucleated mammary epithelial cells in lactation Academic Article
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Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain Academic Article
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Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA Academic Article
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Expression of secreted frizzled-related protein 4 in the primate placenta Academic Article
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Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim Academic Article
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Fli-1 Is Required for Murine Vascular and Megakaryocytic Development and Is Hemizygously Deleted in Patients with Thrombocytopenia Academic Article
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Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL Academic Article
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Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells. Academic Article
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Further Insights into the Effects of Pre-organizing the BimBH3 Helix [Addendum ] Erratum
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Ganging up on Angiotensin II Type 1 Receptors in Vascular Remodeling Academic Article
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Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics Academic Article
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Genetic analysis of ETS genes in C. elegans Academic Article
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Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer Academic Article
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Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM Academic Article
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Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/PE40 ligand toxin in human breast cancer cells Academic Article
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High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies Academic Article
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High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer Academic Article
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Hoxb8 regulates expression of microRNAs to control cell death and differentiation Academic Article
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Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1 Academic Article
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Human ERG is a proto-oncogene with mitogenic and transforming activity Academic Article
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Immunologic competence of B cells subjected to constitutive c-myc oncogene expression in immunoglobulin heavy chain enhancer myc transgenic mice Academic Article
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Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice Academic Article
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Increased Recruitment of Hematopoietic Progenitor Cells Underlies the Ex Vivo Expansion Potential of FLT3 Ligand Academic Article
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Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca
2+
/Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway Academic Article
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Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia Academic Article
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Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1 Academic Article
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Investigating the Potential Role of Genetic and Epigenetic Variation of DNA Methyltransferase Genes in Hyperplastic Polyposis Syndrome Academic Article
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Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. Academic Article
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Isolation of two novel myb-like genes from Arabidopsis and studies on the DNA-binding properties of their products Academic Article
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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins Academic Article
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Limited copy number - high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies Academic Article
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Limiting reductive stress for treating in-stent stenosis: the heart of the matter? Academic Article
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Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands Academic Article
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Localization of four human chromosome 21 genes—SOD1, ETS2, IFNAR, and CBR—to two different chromosomes in the marsupial species Macropus eugenii Academic Article
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Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells Academic Article
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MDM4 is a rational target for treating breast cancers with mutant p53 Academic Article
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MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation Academic Article
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Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine Academic Article
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Mechanisms of Resistance to Crizotinib in Patients withALKGene Rearranged Non–Small Cell Lung Cancer Academic Article
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Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation Academic Article
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MicroRNAs and lymphocyte homeostasis: Dangerous eggs in a single basket Academic Article
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Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis Academic Article
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Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1 Academic Article
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Molecular Cloning Reveals that the p160 Myb-Binding Protein Is a Novel, Predominantly Nucleolar Protein Which May Play a Role in Transactivation by Myb Academic Article
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Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity Academic Article
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Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2. Academic Article
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Oncogene status predicts patterns of metastatic spread in treatment-naive nonsmall cell lung cancer Academic Article
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Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan Academic Article
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Optimisation of the RT-PCR detection of immunomagnetically enriched carcinoma cells Academic Article
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Overexpression of multiple oncogenes related to histological grade of astrocytic glioma Academic Article
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PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer Academic Article
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PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain Academic Article
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Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration Academic Article
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Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2 Academic Article
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Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2 Academic Article
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Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation Academic Article
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Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim Academic Article
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RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation Academic Article
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ROS1
and
ALK
Fusions in Colorectal Cancer, with Evidence of Intratumoral Heterogeneity for Molecular Drivers Academic Article
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Rapid Selection against Truncation Mutants in Yeast Reverse Two-Hybrid Screens Academic Article
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Relationship Between Colorectal Cancer Biomarkers and Response to Epidermal Growth Factor Receptor Monoclonal Antibodies Academic Article
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Relationship between M-BCR breakpoint position in blast crisis and length of chronic phase in chronic myeloid leukemia [letter; comment] Academic Article
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Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL Academic Article
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Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics Academic Article
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Role of p53 in the progression of gastric cancer Academic Article
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SCL gene in human tumors Academic Article
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SCL, the gene implicated in human T-cell leukaemia, is oncogenic in a murine T-lymphocyte cell line Academic Article
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Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo Academic Article
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Sensitive quantification of somatic mutations using molecular inversion probes Academic Article
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Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue Academic Article
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Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity Academic Article
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Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from type 2 diabetes patients: Rescue by α-ketoglutarate and TET-TDG functional reactivation Academic Article
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Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design Academic Article
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Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L Academic Article
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Structural insights into the degradation of Mcl-1 induced by BH3 domains Academic Article
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Studies on the promoter of the Arabidopsis thaliana cdc2a
gene Academic Article
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TR3/Nur77 in colon cancer cell apoptosis Academic Article
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Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer Academic Article
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The (4;11)(q21;p15) Translocation Fuses the NUP98 andRAP1GDS1 Genes and Is Recurrent in T-Cell Acute Lymphocytic Leukemia Academic Article
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The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast Academic Article
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The PKA paradox: is BIM the answer? Academic Article
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The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex Academic Article
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The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger Academic Article
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The Role of the Pro-Apoptotic Bcl-2 Family Member Bim in Physiological Cell Death Conference Paper
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The Wnt Receptor Ryk Is Required for Wnt5a-Mediated Axon Guidance on the Contralateral Side of the Corpus Callosum Academic Article
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The c-Myb Negative Regulatory Domain Conference Paper
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The clinical relevance of pathologic subtypes in metastatic lung adenocarcinoma Academic Article
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The mobilization of primitive hemopoietic progenitors into the peripheral blood Academic Article
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The mouse Plk gene: structural characterization, chromosomal localization and identification of a processed Plk pseudogene Academic Article
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The purification of a Rap1 GTPase-activating protein from bovine brain cytosol Academic Article
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The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist Academic Article
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The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins Academic Article
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The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system Academic Article
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The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy Academic Article
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The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation Academic Article
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The transgenic window on lymphoid malignancy. Academic Article
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Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer Academic Article
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To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions Academic Article
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Tpl2 kinase regulates T cell interferon-γ production and host resistance to Toxoplasma gondii Academic Article
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Transcription factor PU.1 promotes conventional dendritic cell identity and function via induction of transcriptional regulator DC-SCRIPT Academic Article
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Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins Academic Article
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Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1β Production Academic Article
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Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim Academic Article
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Vasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E–Deficient Mice Academic Article
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alpha/beta-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells Academic Article
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erba-related sequence coding for dna-binding hormone receptor localized to chromosome 3p21-3p25 and deleted in small cell lung carcinoma Academic Article