STAT3 Transcription Factor
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ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling Academic Article
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Acquiring signalling specificity from the cytokine receptor gp130 Academic Article
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Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity Academic Article
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Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis Academic Article
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Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy Academic Article
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Colorectal cancer mouse models: integrating inflammation and the stroma Academic Article
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Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction Academic Article
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Control of glioblastoma tumorigenesis by feed-forward cytokine signaling Academic Article
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Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis Academic Article
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Defective Gp130-Mediated Signal Transducer and Activator of Transcription (Stat) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation Academic Article
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Differential Regulation of Gastric Tumor Growth by Cytokines That Signal Exclusively Through the Coreceptor gp130 Academic Article
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Disruption of Mammalian Target of Rapamycin Complex 1 in Macrophages Decreases Chemokine Gene Expression and Atherosclerosis Academic Article
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Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer Academic Article
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EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma Academic Article
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Epithelial gp130/Stat3 functions: An intestinal signaling node in health and disease Academic Article
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Forced Dimerization of gp130 Leads to Constitutive STAT3 Activation, Cytokine-independent Growth, and Blockade of Differentiation of Embryonic Stem Cells Academic Article
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General Nature of the STAT3-Activated Anti-Inflammatory Response Academic Article
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Generation of an inducible mouse model to reversibly silence Stat3 Academic Article
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Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis Academic Article
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Growth restriction in the rat alters expression of cardiac JAK/STAT genes in a sex-specific manner Academic Article
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Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling Academic Article
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Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA Academic Article
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Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling Academic Article
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IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3 Academic Article
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IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3 Academic Article
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IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation Academic Article
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Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression Academic Article
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Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men Academic Article
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Increased tumor-infiltrating CD45RA−CCR7− regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress Academic Article
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Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors Academic Article
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Influence of Interleukin-6 (IL-6) Dimerization on Formation of the High Affinity Hexameric IL-6·Receptor Complex Academic Article
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Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression Academic Article
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Inhibition of the SRC kinase HCK impairs STAT3-dependent gastric tumor growth in mice Academic Article
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Interleukin-11 links oxidative stress and compensatory proliferation Academic Article
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Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 Academic Article
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Involvement of gp130-associated cytokine signaling in Müller cell activation following optic nerve lesion Academic Article
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LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling Academic Article
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Mammary Gland Remodeling Depends on gp130 Signaling through Stat3 and MAPK Academic Article
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MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2 Academic Article
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Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis Academic Article
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Molecular Dissection of gp130-dependent Pathways in Hepatocytes during Liver Regeneration Academic Article
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Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers Academic Article
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More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer Academic Article
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Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation Academic Article
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Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration Academic Article
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Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis Academic Article
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Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth Academic Article
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SOCS3 negatively regulates LIF signaling in neural precursor cells Academic Article
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STAT3 Activation Regulates Growth, Inflammation, and Vascularization in a Mouse Model of Gastric Tumorigenesis Academic Article
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STAT3 Forms Stable Homodimers in the Presence of Divalent Cations Prior to Activation Academic Article
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STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo Academic Article
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STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice Academic Article
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STAT3-activating cytokines: A therapeutic opportunity for inflammatory bowel disease? Academic Article
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Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus Academic Article
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Stat3: Linking inflammation to (gastrointestinal) tumourigenesis Academic Article
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Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model Academic Article
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Targeting JAK kinase in solid tumors: emerging opportunities and challenges Academic Article
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The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation Academic Article
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The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury Academic Article
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The Interleukin-6 Family Cytokine Interleukin-11 Regulates Homeostatic Epithelial Cell Turnover and Promotes Gastric Tumor Development Academic Article
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The JAK/STAT3 axis: A comprehensive drug target for solid malignancies Academic Article
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The Mycoplasma hyorhinis p37 Protein Rapidly Induces Genes in Fibroblasts Associated with Inflammation and Cancer Academic Article
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The Walrus and the Carpenter: Complex Regulation of Tumor Immunity in Colorectal Cancer Academic Article
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The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma Academic Article
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The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis Academic Article
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The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice Academic Article
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Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis Academic Article
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Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice Academic Article
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Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map Academic Article
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Upexpression of BHLHE40 in gastric epithelial cells increases CXCL12 production through interaction with p-STAT3 in Helicobacter pylori-associated gastritis Academic Article
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gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis Academic Article
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mTORC1 inhibition restricts infammation-associated gastrointestinal tumorigenesis in mice Academic Article