subject area of

• ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling  Academic Article
• Acquiring signalling specificity from the cytokine receptor gp130  Academic Article
• Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity  Academic Article
• Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis  Academic Article
• Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy  Academic Article
• Colorectal cancer mouse models: integrating inflammation and the stroma  Academic Article
• Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction  Academic Article
• Control of glioblastoma tumorigenesis by feed-forward cytokine signaling  Academic Article
• Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis  Academic Article
• Defective Gp130-Mediated Signal Transducer and Activator of Transcription (Stat) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation  Academic Article
• Differential Regulation of Gastric Tumor Growth by Cytokines That Signal Exclusively Through the Coreceptor gp130  Academic Article
• Disruption of Mammalian Target of Rapamycin Complex 1 in Macrophages Decreases Chemokine Gene Expression and Atherosclerosis  Academic Article
• Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer  Academic Article
• EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma  Academic Article
• Epithelial gp130/Stat3 functions: An intestinal signaling node in health and disease  Academic Article
• Forced Dimerization of gp130 Leads to Constitutive STAT3 Activation, Cytokine-independent Growth, and Blockade of Differentiation of Embryonic Stem Cells  Academic Article
• General Nature of the STAT3-Activated Anti-Inflammatory Response  Academic Article
• Generation of an inducible mouse model to reversibly silence Stat3  Academic Article
• Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis  Academic Article
• Growth restriction in the rat alters expression of cardiac JAK/STAT genes in a sex-specific manner  Academic Article
• Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling  Academic Article
• Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA  Academic Article
• Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling  Academic Article
• IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3  Academic Article
• IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3  Academic Article
• IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation  Academic Article
• Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression  Academic Article
• Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men  Academic Article
• Increased tumor-infiltrating CD45RA−CCR7− regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress  Academic Article
• Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors  Academic Article
• Influence of Interleukin-6 (IL-6) Dimerization on Formation of the High Affinity Hexameric IL-6·Receptor Complex  Academic Article
• Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression  Academic Article
• Interleukin-11 links oxidative stress and compensatory proliferation  Academic Article
• Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10  Academic Article
• Involvement of gp130-associated cytokine signaling in Müller cell activation following optic nerve lesion  Academic Article
• LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling  Academic Article
• Mammary Gland Remodeling Depends on gp130 Signaling through Stat3 and MAPK  Academic Article
• Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis  Academic Article
• Molecular Dissection of gp130-dependent Pathways in Hepatocytes during Liver Regeneration  Academic Article
• Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers  Academic Article
• More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer  Academic Article
• Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial  Academic Article
• Opposing Actions of Extracellular Signal-regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy  Academic Article
• Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation  Academic Article
• Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration  Academic Article
• Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis  Academic Article
• SOCS3 negatively regulates LIF signaling in neural precursor cells  Academic Article
• STAT3 Activation Regulates Growth, Inflammation, and Vascularization in a Mouse Model of Gastric Tumorigenesis  Academic Article
• STAT3 Forms Stable Homodimers in the Presence of Divalent Cations Prior to Activation  Academic Article
• STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo  Academic Article
• STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice  Academic Article
• STAT3-activating cytokines: A therapeutic opportunity for inflammatory bowel disease?  Academic Article
• STAT3α Is Oncogenic for Endometrial Carcinoma Cells and Mediates the Oncogenic Effects of Autocrine Human Growth Hormone  Academic Article
• Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus  Academic Article
• Stat3: Linking inflammation to (gastrointestinal) tumourigenesis  Academic Article
• Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model  Academic Article
• Targeting JAK kinase in solid tumors: emerging opportunities and challenges  Academic Article
• The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation  Academic Article
• The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury  Academic Article
• The Interleukin-6 Family Cytokine Interleukin-11 Regulates Homeostatic Epithelial Cell Turnover and Promotes Gastric Tumor Development  Academic Article
• The JAK/STAT3 axis: A comprehensive drug target for solid malignancies  Academic Article
• The Mycoplasma hyorhinis p37 Protein Rapidly Induces Genes in Fibroblasts Associated with Inflammation and Cancer  Academic Article
• The Walrus and the Carpenter: Complex Regulation of Tumor Immunity in Colorectal Cancer  Academic Article
• The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma  Academic Article
• The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis  Academic Article
• The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice  Academic Article
• Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis  Academic Article
• Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice  Academic Article
• Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map  Academic Article
• gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis  Academic Article
• mTORC1 inhibition restricts infammation-associated gastrointestinal tumorigenesis in mice  Academic Article