subject area of

• 'Click' assembly of glycoclusters and discovery of a trehalose analogue that retards Aβ40 aggregation and inhibits Aβ40-induced neurotoxicity  Academic Article
• (α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xLRecognition:  Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions  Academic Article
• 19F nuclear magnetic resonance spectroscopy study of the complex of 2-benzyl-4-oxo-5,5,5-trifluoropentanoic acid and carboxypeptidase A  Academic Article
• 3-Phosphonopropionic acids inhibit carboxypeptidase A as multisubstrate analogues or transition-state analogues  Academic Article
• A Helical Conotoxin fromConus imperialisHas a Novel Cysteine Framework and Defines a New Superfamily  Academic Article
• A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4  Academic Article
• A New Class of Blockers of the Voltage-Gated Potassium Channel Kv1.3 via Modification of the 4- or 7-Position of Khellinone  Academic Article
• A Quantitative Structure−Activity Relationships Model for the Acute Toxicity of Substituted Benzenes toTetrahymena pyriformisUsing Bayesian-Regularized Neural Networks  Academic Article
• A high-performance liquid chromatography procedure for recovering subnanomole amounts of protein from SDS-gel electroeluates for gas-phase sequence analysis  Academic Article
• A microbore high-performance liquid chromatography strategy for the purification of polypeptides for gas-phase sequence analysis. Structural studies on the murine transferrin receptor  Academic Article
• A molecular approach in drug development for Alzheimer’s disease  Academic Article
• A pharmacological study of NLP-12 neuropeptide signaling in free-living and parasitic nematodes  Academic Article
• A renaissance of neural networks in drug discovery  Academic Article
• A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling  Academic Article
• A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition  Academic Article
• A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin  Academic Article
• Accurate and interpretable nanoSAR models from genetic programming-based decision tree construction approaches  Academic Article
• Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme  Academic Article
• Affinity Purification, Overexpression, and Characterization of Chaperonin 10 Homologues Synthesized with and without N-terminal Acetylation  Academic Article
• Aldehyde and ketone substrate analogs inhibit the collagenase of Clostridium histolyticum  Academic Article
• An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors.  Academic Article
• Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity  Academic Article
• Analysis of structure and function of the giant protein Pf332 inPlasmodium falciparum  Academic Article
• Antithrombins Wibble and Wobble (T85M/K): Archetypal Conformational Diseases With In Vivo Latent-Transition, Thrombosis, and Heparin Activation  Academic Article
• Antiviral and Antiproliferative Activities of Interferon-α1: The Role of Cysteine Residues  Academic Article
• Application of analytical and semi-preparative high-performance liquid chromatography to anthracyclines and bis-anthracycline derivatives  Academic Article
• Application of the artificial neural network in quantitative structure–gradient elution retention relationship of phenylthiocarbamyl amino acids derivatives  Academic Article
• Barminomycin forms GC-specific adducts and virtual interstrand crosslinks with DNA  Academic Article
• Binding Inhibitors of the Bacterial Sliding Clamp by Design  Academic Article
• Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization  Academic Article
• Bioinformatics tools and resources for analyzing protein structures  Chapter
• Biomimetic Topography and Chemistry Control Cell Attachment to Amyloid Fibrils  Academic Article
• CLE peptide tri-arabinosylation and peptide domain sequence composition are essential for SUNN-dependent autoregulation of nodulation in Medicago truncatula  Academic Article
• CTL Recognition of an Altered Peptide Associated with Asparagine Bond Rearrangement: Implications for Immunity and Vaccine Design  Academic Article
• Can cyclic HIV protease inhibitors bind in a non-preferred form? An ab initio, DFT and MM-PB(GB)SA study  Academic Article
• Changing the solvent accessibility of the prion protein disulfide bond markedly influences its trafficking and effect on cell function  Academic Article
• Chemiluminescence detection of piperazine designer drugs and related compounds using tris(2,2′-bipyridine)ruthenium(III)  Academic Article
• Chimeric Fc receptors identify functional domains of the murine high affinity receptor for IgG  Academic Article
• Comparison of Native and Mutant Proteins Provides a Sequence-Specific Assignment of the Cysteinyl Ligand Proton NMR Resonances in the 2[Fe4S4] Ferredoxin from Clostridium pasteurianum  Academic Article
• Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands  Academic Article
• Conserved extracellular cysteine residues and cytoplasmic loop–loop interplay are required for functionality of the heptahelical MLO protein  Academic Article
• Conserved main‐chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase  Academic Article
• Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design  Academic Article
• Copper Complexes in Cancer Therapy  Chapter
• Cortisol resistance and the guinea pig glucocorticoid receptor  Academic Article
• Cross-presentation of a human malaria CTL epitope is conformation dependent  Academic Article
• Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins  Academic Article
• Cyclic nucleotide monophosphates in plants and plant signaling  Chapter
• Cytotoxic and DNA binding properties of aminoalkyl derivatives of di- and triazaphenanthrenes  Academic Article
• DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues  Academic Article
• DNA targeted platinum complexes: synthesis, cytotoxicity and DNA interactions of cis-dichloroplatinum(II) complexes tethered to phenazine-1-carboxamides  Academic Article
• De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization  Academic Article
• Decoding the Rich Biological Properties of Noble Gases: How Well Can We Predict Noble Gas Binding to Diverse Proteins?  Academic Article
• Design of potential anti-HIV agents. 1. Mannosidase inhibitors  Academic Article
• Design, synthesis and binding properties of a fluorescent α₉β₁/α₄β₁ integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells  Academic Article
• Development of a Mycobacterium smegmatis transposon mutant array for characterising the mechanism of action of tuberculosis drugs: Findings with isoniazid and its structural analogues  Academic Article
• Differences in protein structural regions that impact functional specificity in GT2 family β- Glucan synthases  Academic Article
• Differential Inhibition of Cyclic AMP-Dependent Protein Kinase, Myosin Light Chain Kinase and Protein Kinase C by Azaacridine and Acridine Derivatives  Academic Article
• Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)  Academic Article
• Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[ b ]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties  Academic Article
• Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques  Academic Article
• EVALUATION OF PORPHYRIN CHARACTERISTICS REQUIRED FOR PHOTODYNAMIC THERAPY  Academic Article
• Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin  Academic Article
• Effect of deletions within the leader peptide of pre-ornithine transcarbamylase on mitochondrial import  Academic Article
• Effect of some quaternary benzylammonium salts on physiology of yeast.  Academic Article
• Electron-Deficient DNA Intercalating Agents as Antitumor Drugs: Aza Analogs of the Experimental Clinical Agent N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide  Academic Article
• Engineering Poly(ethylene glycol) Particles for Improved Biodistribution  Academic Article
• Evaluation of porphyrin C analogues for photodynamic therapy of cerebral glioma  Academic Article
• Evidence That Serpin Architecture Intrinsically Supports Papain-like Cysteine Protease Inhibition:  Engineering α1-Antitrypsin To Inhibit Cathepsin Proteases†  Academic Article
• Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum  Academic Article
• Extending Halogen-based Medicinal Chemistry to Proteins IODO-INSULIN AS A CASE STUDY  Academic Article
• FX-06, a fibrin-derived Bβ15-42 peptide for the potential treatment of reperfusion injury following myocardial infarction  Academic Article
• Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species  Academic Article
• Formation of adriamycin-DNA adductsin vitro  Academic Article
• Fra-1 replaces c-Fos-dependent functions in mice  Academic Article
• Functional implications of modifying RyR-activating peptides for membrane permeability  Academic Article
• Functional responses of bone cells to thrombin  Academic Article
• GPIIb/IIIa inhibitors: From bench to bedside and back to bench again  Academic Article
• Genetic defect in N-acetylglucosaminyltransferase I gene of a ricin-resistant baby hamster kidney mutant  Academic Article
• Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component  Academic Article
• Gold and Silver Nanoparticles Biomimetically Synthesized Using Date Palm Pollen Extract-Induce Apoptosis and Regulate p53 and Bcl-2 Expression in Human Breast Adenocarcinoma Cells  Academic Article
• Heparin assisted assembly of somatostatin amyloid nanofibrils results in disordered precipitates by hindrance of protofilaments interactions  Academic Article
• High-affinity Cyclic Peptide Matriptase Inhibitors  Academic Article
• High-resolution crystal structure of the reduced Grx1 from Saccharomyces cerevisiae  Academic Article
• Horner-Wadsworth-Emmons approach to piperlongumine analogues with potent anti-cancer activity  Academic Article
• Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA  Academic Article
• Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10  Academic Article
• Identification of the binding site of apical membrane antigen 1 (AMA1) inhibitors using a paramagnetic probe  Academic Article
• Identification of the peptides that inhibit the stimulation of thyrotropin receptor by Graves' immunoglobulin G from peptide libraries  Academic Article
• Immunochemical characterization of two thyroid-stimulating hormone β-subunit epitopes  Academic Article
• In vitro and in planta cyclization of target peptides using an asparaginyl endopeptidase from oldenlandia affinis  Chapter
• Inhibition of angiotensin converting enzyme by aldehyde and ketone substrate analogs  Academic Article
• Inhibition of carboxypeptidase A by ketones and alcohols that are isosteric with peptide substrates  Academic Article
• Inhibition of human skin fibroblast collagenase by phosphorus-containing peptides.  Academic Article
• Inhibition of the collagenase from Clostridium histolyticum by phosphoric and phosphonic amides  Academic Article
• Inhibition of the elastase of Pseudomonas aeruginosa by N.alpha.-phosphoryl dipeptides and kinetics of spontaneous hydrolysis of the inhibitors  Academic Article
• Inhibition of wheat embryo calcium-dependent protein kinase by acridines and azaacridines  Academic Article
• Inhibitors of Metalloendopeptidase EC 3.4.24.15 and EC 3.4.24.16 Stabilized against Proteolysis by the Incorporation of β-Amino Acids  Academic Article
• Insight into Schmid Metaphyseal Chondrodysplasia from the Crystal Structure of the Collagen X NC1 Domain Trimer  Academic Article
• Insights into structure and function of the active site of SoxAX cytochromes  Academic Article
• Introduction of a Mutation in the Shutter Region of Antithrombin (Phe77 → Leu) Increases Affinity for Heparin and Decreases Thermal Stability†  Academic Article
• Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues  Academic Article
• Isolation and complete amino acid sequence of a basic low molecular weight protein from black swan egg white.  Academic Article
• Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B  Academic Article
• Kinetic and Crystallographic Analysis of MutantEscherichia coliAminopeptidase P:  Insights into Substrate Recognition and the Mechanism of Catalysis†  Academic Article
• Kinetic and Structural Analysis of MutantEscherichia coliDihydroorotases:  A Flexible Loop Stabilizes the Transition State†,‡  Academic Article
• Lactam-Stabilized Helical Analogues of the Analgesic μ-Conotoxin KIIIA  Academic Article
• Les IAP au cœur de la signalisation NF-κB  Academic Article
• Ligand release mechanisms and channels in histone deacetylases  Academic Article
• M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe  Academic Article
• Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?  Academic Article
• Matrix Metalloproteinase Inhibitors:  A Structure−Activity Study  Academic Article
• Melittin peptides exhibit different activity on different cells and model membranes  Academic Article
• Mining Characteristic Relations Bind to RNA Secondary Structures  Conference Paper
• Modeling Biological Activities of Nanoparticles  Academic Article
• Molecular Modeling Studies of “Flap Up” Mannosyl Cation Mimics  Academic Article
• Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity  Academic Article
• Molecular descriptors that influence the amount of drugs transfer into human breast milk  Academic Article
• Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist  Academic Article
• Murine epidermal growth factor: structure and function  Academic Article
• N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3  Academic Article
• N.alpha.-(O,O'-Diphenoxyphosphoryl)-L-alanyl-L-proline, N.alpha.-[O,O'-bis(4-nitrophenoxy)phosphoryl]-L-alanyl-L-proline and N.alpha.-[P-(2-phenylethyl)-O-phenoxyphosphoryl]-L-alanyl-L-proline: releasers of potent inhibitors of angiotensin converting enzyme at physiological pH and temperature  Academic Article
• New 1-Aryl-3-(4-arylpiperazin-1-yl)propane Derivatives, with Dual Action at 5-HT1ASerotonin Receptors and Serotonin Transporter, as a New Class of Antidepressants  Academic Article
• New Anthracenedione Derivatives with Improved Biological Activity by Virtue of Stable Drug−DNA Adduct Formation  Academic Article
• Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens  Academic Article
• Overexpression of Endogenous Anti-Oxidants with Selenium Supplementation Protects Trophoblast Cells from Reactive Oxygen Species-Induced Apoptosis in a Bcl-2-Dependent Manner  Academic Article
• PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues  Academic Article
• POPS: A COMPUTATIONAL TOOL FOR MODELING AND PREDICTING PROTEASE SPECIFICITY  Academic Article
• Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides  Academic Article
• Phosphatidylinositol mannosides: Synthesis and suppression of allergic airway disease  Academic Article
• PoPS: a computational tool for modeling and predicting protease specificity  Conference Paper
• PoPS: a computational tool for modeling and predicting protease specificity.  Academic Article
• Polysaccharides Influence the Aggregation of Dictyostelium discoideum Cells and Bind to Developmentally Regulated Cell Surface Proteins  Academic Article
• Positioning of the Carboxamide Side Chain in 11-Oxo-11 H -indeno[1,2- b ]quinolinecarboxamide Anticancer Agents: Effects on Cytotoxicity  Academic Article
• Potent Agonists of a Hematopoietic Stem Cell Cytokine Receptor, c-Mpl  Academic Article
• Potent Inhibitors of Phosphatidylinositol 3 (PI3) Kinase that have Antiproliferative Activity Only When Delivered as Prodrug Forms  Academic Article
• Potential therapeutic targets and the role of technology in developing novel antileishmanial drugs  Academic Article
• Probing the structure of Leishmania major DHFR TS and structure based virtual screening of peptide library for the identification of anti-leishmanial leads  Academic Article
• Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite  Academic Article
• Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC  Academic Article
• Progress in the Development of Platelet-Activating Factor Receptor (PAFr) Antagonists and Applications in the Treatment of Inflammatory Diseases  Academic Article
• Protease-responsive prodrug with aggregation-induced emission probe for controlled drug delivery and drug release tracking in living cells  Academic Article
• QSAR studies of hydrazone uncouplers of oxidative phosphorylation  Academic Article
• Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity  Academic Article
• Radiosynthesis and Biological Evaluation ofl- andd-S-(3-[18F]Fluoropropyl)homocysteine for Tumor Imaging Using Positron Emission Tomography  Academic Article
• Rapid Prediction of Chemical Metabolism by Human UDP-glucuronosyltransferase Isoforms Using Quantum Chemical Descriptors Derived with the Electronegativity Equalization Method  Academic Article
• Reactivity and Transformation of Antimetastatic and Cytotoxic Rhodium(III)–Dimethyl Sulfoxide Complexes in Biological Fluids: An XAS Speciation Study  Academic Article
• Recent Advances in Understanding and Exploiting the Activation of Anthracyclines by Formaldehyde  Academic Article
• Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V  Academic Article
• Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors  Academic Article
• Reengineering Antibiotics to Combat Bacterial Resistance: Click Chemistry [1,2,3]-Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE  Academic Article
• Ribosome-inactivating proteins: Current status and biomedical applications  Academic Article
• Ring-substituted 11-oxo-11 H -indeno[1,2- b ]quinoline-6-carboxamides with similar patterns of cytotoxicity to the dual topo I/II inhibitor DACA  Academic Article
• Robust QSAR Models Using Bayesian Regularized Neural Networks  Academic Article
• Role of the C-terminus in the activity, conformation, and stability of interleukin-6  Academic Article
• Roles of Histidine 31 and Tryptophan 34 in the Structure, Self-Association, and Folding of Murine Interleukin-6†  Academic Article
• Selective Inhibition of Cyclic AMP-Dependent Protein Kinase by Isoquinoline Derivatives  Academic Article
• Selective phosphinate transition-state analogue inhibitors of the protease of human immunodeficiency virus  Academic Article
• Serpins in Prokaryotes  Academic Article
• Serpins: Finely Balanced Conformational Traps  Academic Article
• Single amino acid substititons at conserved residues of human interferon-α can effect antiviral specific activity  Academic Article
• Single amino acid substitution altering antigen-binding specificity.  Academic Article
• Snake venom probes of platelet adhesion receptors and their ligands  Academic Article
• Strategy for the Development of a Thermodynamically Stable Oral Microemulsion  Academic Article
• Structural Basis for Broad Substrate Specificity in Higher Plant β-d-Glucan Glucohydrolases  Academic Article
• Structural Basis for Tetrodotoxin-resistant Sodium Channel Binding by μ-Conotoxin SmIIIA  Academic Article
• Structural Determinants of Cortisol Resistance in the Guinea Pig Glucocorticoid Receptor1  Academic Article
• Structural Determinants of the Interaction between the erbB2 Receptor and the Src Homology 2 Domain of Grb7  Academic Article
• Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis  Academic Article
• Structural and Biological Characterization of Murine-Human Interleukin-6 Chimeras  Conference Paper
• Structural and Functional Characterization of the Oxidoreductase α-DsbA1 from Wolbachia pipientis  Academic Article
• Structural and Functional Diversities among μ-Conotoxins Targeting TTX-resistant Sodium Channels†  Academic Article
• Structural and functional characterization of receptor kinases with nucleotide cyclase activity  Chapter
• Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis  Academic Article
• Structural basis of subtilase cytotoxin SubAB assembly.  Academic Article
• Structural requirements for the formation of anthracycline - DNA adducts  Academic Article
• Structure and function of cyanobacterial DHDPS and DHDPR  Academic Article
• Structure of Aldehyde Reductase Holoenzyme in Complex with the Potent Aldose Reductase Inhibitor Fidarestat:  Implications for Inhibitor Binding and Selectivity  Academic Article
• Structure of the Analgesic μ-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion†‡  Academic Article
• Structure of the T109S mutant ofEscherichia colidihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form  Academic Article
• Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation  Academic Article
• Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction  Academic Article
• Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference  Academic Article
• Structure-Function analysis of human IL-6: Identification of two distinct regions that are important for receptor binding  Academic Article
• Structure-activity relations of convulsant and anticonvulsant barbiturates: a computer-graphic-based pattern-recognition analysis  Academic Article
• Structure-activity relationships in quinoline reissert derivatives with hiv-1 reverse transcriptase inhibitory activity  Academic Article
• Structure-based design of inhibitors of human l-xylulose reductase modelled into the active site of the enzyme  Academic Article
• Structure-based design of selective high-affinity telomeric quadruplex-binding ligands  Academic Article
• Structure-based drug design to augment hit discovery  Academic Article
• Structure-guided design of a novel class of benzyl-sulfonate inhibitors for influenza virus neuraminidase  Academic Article
• Structure-retention relationships of diuretics in reversed-phase liquid chromatography  Academic Article
• Structure/Function Relationships of Apolipoprotein A-I Mimetic Peptides  Academic Article
• Structure–function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins  Academic Article
• Studies on 3-Deoxy-d-arabinoheptulosonate-7-phosphate Synthetase(phe) from Escherichia coli K12. 3. Structural Studies  Academic Article
• Substituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists  Academic Article
• Synthesis and Antitumor Properties ofN-[2-(Dimethylamino)ethyl]carboxamide Derivatives of Fused Tetracyclic Quinolines and Quinoxalines:  A New Class of Putative Topoisomerase Inhibitors  Academic Article
• Synthesis and Cytotoxic Activity of 7-Oxo-7H-dibenz[f,ij]isoquinoline and 7-Oxo-7H-benzo[e]perimidine Derivatives  Academic Article
• Synthesis and Cytotoxic Activity of Carboxamide Derivatives of Benzo[b][1,6]naphthyridines  Academic Article
• Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives  Academic Article
• Synthesis and anti-inflammatory activity of indole glucosinolates  Academic Article
• Synthesis and biological evaluation of 2-anilino-4-substituted-7H-pyrrolopyrimidines as PDK1 inhibitors  Academic Article
• Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[ e ][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation  Academic Article
• Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors  Academic Article
• Synthesis and cytotoxic activity of N -(2-Diethylamino)ethylcarboxamide and other derivatives of 10 H -Quindoline  Academic Article
• Synthesis and cytotoxic activity of N-[(alkylamino)alkyl]carboxamide derivatives of 7-oxo-7H-benz[de]anthracene, 7-oxo-7H-naphtho[1,2,3-de]quinoline, and 7-oxo-7H-benzo[e]perimidine  Academic Article
• Synthesis and cytotoxic activity of carboxamide derivatives of benzimidazo[2,1-a]isoquinoline and pyrido [3′, 2′: 4,5] imidazo [2,1 -a] isoquinoline  Academic Article
• Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridin-(5H)ones  Academic Article
• Synthesis of Substituted Indeno[1,2-b]quinoline-6-carboxamides, [1]benzothieno[3,2-b]quinoline-4-carboxamides and 10H-quindoline-4-carboxamides: Evaluation of Structure–Activity Relationships for Cytotoxicity  Academic Article
• Synthesis of novel 1,2,5-oxadiazoles and evaluation of action against Acinetobacter baumannii  Academic Article
• Synthesis of polyamine-linked bis-daunomycin hydrazones and their interaction with DNA  Academic Article
• Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines  Academic Article
• Synthesis, Testing and Structure-Activity Studies on a Library of 5-HT4 Ligands  Academic Article
• Synthesis, binding and bioactivity of γ-methylene γ-lactam ecdysone receptor ligands: Advantages of QSAR models for flexible receptors  Academic Article
• Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines  Academic Article
• Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8-and 6-aryl-substituted-1-3-benzoxazines  Academic Article
• Synthesis, structure elucidation, DNA-PK, PI3K, anti-platelet and anti-bacteria activity of linear 5, 6, and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3, 4, 6-substituted-8-morpholino-chromen-oxazine-2,10-dione  Academic Article
• Synthetic routes to the neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging  Academic Article
• Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5  Academic Article
• Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands  Academic Article
• The 5′-CA DNA-sequence preference of daunomycin  Academic Article
• The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation  Academic Article
• The DNA-association and biological activity of a new bis(14-thiadaunomycin)  Academic Article
• The Interaction of Daunomycin with Polydeoxynucleotides  Academic Article
• The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition  Academic Article
• The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors  Academic Article
• The Role of Intracellularly Released Formaldehyde and Butyric Acid in the Anticancer Activity of Acyloxyalkyl Esters  Academic Article
• The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis  Academic Article
• The Three-dimensional Solution Structure of NaD1, a New Floral Defensin from Nicotiana alata and its Application to a Homology Model of the Crop Defense Protein alfAFP  Academic Article
• The UBA domain of SnRK1 promotes activation and maintains catalytic activity  Academic Article
• The antitumor monoclonal antibody 806 recognizes a high‐mannose form of the EGF receptor that reaches the cell surface when cells over‐express the receptor  Academic Article
• The defensins consist of two independent, convergent protein superfamilies  Academic Article
• The ketone cinnamoyl-(1-13C-Phe)-CGly-Pro-Pro is a tetrahedral transition state analog inhibitor of C. histolyticum collagenase  Academic Article
• Tim22, the Essential Core of the Mitochondrial Protein Insertion Complex, Forms a Voltage-Activated and Signal-Gated Channel  Academic Article
• Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P-falciparum and P-vivax  Academic Article
• Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion  Academic Article
• Use of ANN modelling in structure–retention relationships of diuretics in RP-HPLC  Academic Article
• XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity  Academic Article