Structure-Activity Relationship
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"Register-shift” insulin analogs uncover constraints of proteotoxicity in protein evolution Academic Article
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'Click' assembly of glycoclusters and discovery of a trehalose analogue that retards Aβ40 aggregation and inhibits Aβ40-induced neurotoxicity Academic Article
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(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xLRecognition: Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions Academic Article
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19F nuclear magnetic resonance spectroscopy study of the complex of 2-benzyl-4-oxo-5,5,5-trifluoropentanoic acid and carboxypeptidase A Academic Article
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3-Phosphonopropionic acids inhibit carboxypeptidase A as multisubstrate analogues or transition-state analogues Academic Article
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A Helical Conotoxin fromConus imperialisHas a Novel Cysteine Framework and Defines a New Superfamily Academic Article
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A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4 Academic Article
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A New Class of Blockers of the Voltage-Gated Potassium Channel Kv1.3 via Modification of the 4- or 7-Position of Khellinone Academic Article
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A Quantitative Structure−Activity Relationships Model for the Acute Toxicity of Substituted Benzenes toTetrahymena pyriformisUsing Bayesian-Regularized Neural Networks Academic Article
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A high-performance liquid chromatography procedure for recovering subnanomole amounts of protein from SDS-gel electroeluates for gas-phase sequence analysis Academic Article
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A microbore high-performance liquid chromatography strategy for the purification of polypeptides for gas-phase sequence analysis. Structural studies on the murine transferrin receptor Academic Article
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A molecular approach in drug development for Alzheimer’s disease Academic Article
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A pharmacological study of NLP-12 neuropeptide signaling in free-living and parasitic nematodes Academic Article
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A renaissance of neural networks in drug discovery Academic Article
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A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling Academic Article
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A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition Academic Article
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A structurally minimized yet fully active insulin based on cone-snail venom insulin principles Academic Article
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A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin Academic Article
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Accurate and interpretable nanoSAR models from genetic programming-based decision tree construction approaches Academic Article
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Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme Academic Article
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Affinity Purification, Overexpression, and Characterization of Chaperonin 10 Homologues Synthesized with and without N-terminal Acetylation Academic Article
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Aldehyde and ketone substrate analogs inhibit the collagenase of Clostridium histolyticum Academic Article
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An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors. Academic Article
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Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity Academic Article
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Analysis of structure and function of the giant protein Pf332 inPlasmodium falciparum Academic Article
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Antithrombins Wibble and Wobble (T85M/K): Archetypal Conformational Diseases With In Vivo Latent-Transition, Thrombosis, and Heparin Activation Academic Article
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Antiviral and Antiproliferative Activities of Interferon-α1: The Role of Cysteine Residues Academic Article
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Application of analytical and semi-preparative high-performance liquid chromatography to anthracyclines and bis-anthracycline derivatives Academic Article
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Application of the artificial neural network in quantitative structure–gradient elution retention relationship of phenylthiocarbamyl amino acids derivatives Academic Article
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Barminomycin forms GC-specific adducts and virtual interstrand crosslinks with DNA Academic Article
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Binding Inhibitors of the Bacterial Sliding Clamp by Design Academic Article
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Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization Academic Article
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Bioinformatics tools and resources for analyzing protein structures Chapter
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Biomimetic Topography and Chemistry Control Cell Attachment to Amyloid Fibrils Academic Article
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CLE peptide tri-arabinosylation and peptide domain sequence composition are essential for SUNN-dependent autoregulation of nodulation in Medicago truncatula Academic Article
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CTL Recognition of an Altered Peptide Associated with Asparagine Bond Rearrangement: Implications for Immunity and Vaccine Design Academic Article
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Can cyclic HIV protease inhibitors bind in a non-preferred form? An ab initio, DFT and MM-PB(GB)SA study Academic Article
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Changing the solvent accessibility of the prion protein disulfide bond markedly influences its trafficking and effect on cell function Academic Article
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Chemiluminescence detection of piperazine designer drugs and related compounds using tris(2,2′-bipyridine)ruthenium(III) Academic Article
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Chimeric Fc receptors identify functional domains of the murine high affinity receptor for IgG Academic Article
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Comparison of Native and Mutant Proteins Provides a Sequence-Specific Assignment of the Cysteinyl Ligand Proton NMR Resonances in the 2[Fe4S4] Ferredoxin from Clostridium pasteurianum Academic Article
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Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands Academic Article
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Conserved main‐chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase Academic Article
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Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design Academic Article
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Copper Complexes in Cancer Therapy Chapter
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Cortisol resistance and the guinea pig glucocorticoid receptor Academic Article
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Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin Academic Article
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Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins Academic Article
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Cyclic nucleotide monophosphates in plants and plant signaling Chapter
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Cytotoxic and DNA binding properties of aminoalkyl derivatives of di- and triazaphenanthrenes Academic Article
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DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues Academic Article
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DNA targeted platinum complexes: synthesis, cytotoxicity and DNA interactions of cis-dichloroplatinum(II) complexes tethered to phenazine-1-carboxamides Academic Article
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De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization Academic Article
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Decoding the Rich Biological Properties of Noble Gases: How Well Can We Predict Noble Gas Binding to Diverse Proteins? Academic Article
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Design of potential anti-HIV agents. 1. Mannosidase inhibitors Academic Article
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Design, synthesis and binding properties of a fluorescent α₉β₁/α₄β₁ integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells Academic Article
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Development of a Mycobacterium smegmatis transposon mutant array for characterising the mechanism of action of tuberculosis drugs: Findings with isoniazid and its structural analogues Academic Article
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Differences in protein structural regions that impact functional specificity in GT2 family β- Glucan synthases Academic Article
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Differential Inhibition of Cyclic AMP-Dependent Protein Kinase, Myosin Light Chain Kinase and Protein Kinase C by Azaacridine and Acridine Derivatives Academic Article
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Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea) Academic Article
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Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[ b ]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties Academic Article
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Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques Academic Article
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EVALUATION OF PORPHYRIN CHARACTERISTICS REQUIRED FOR PHOTODYNAMIC THERAPY Academic Article
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Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin Academic Article
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Effect of deletions within the leader peptide of pre-ornithine transcarbamylase on mitochondrial import Academic Article
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Effect of some quaternary benzylammonium salts on physiology of yeast. Academic Article
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Electron-Deficient DNA Intercalating Agents as Antitumor Drugs: Aza Analogs of the Experimental Clinical Agent N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide Academic Article
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Engineering Poly(ethylene glycol) Particles for Improved Biodistribution Academic Article
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Evaluation of porphyrin C analogues for photodynamic therapy of cerebral glioma Academic Article
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Evidence That Serpin Architecture Intrinsically Supports Papain-like Cysteine Protease Inhibition: Engineering α1-Antitrypsin To Inhibit Cathepsin Proteases† Academic Article
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Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum Academic Article
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Extending Halogen-based Medicinal Chemistry to Proteins IODO-INSULIN AS A CASE STUDY Academic Article
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FX-06, a fibrin-derived Bβ15-42 peptide for the potential treatment of reperfusion injury following myocardial infarction Academic Article
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Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species Academic Article
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Formation of adriamycin-DNA adductsin vitro Academic Article
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Functional implications of modifying RyR-activating peptides for membrane permeability Academic Article
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Functional responses of bone cells to thrombin Academic Article
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GPIIb/IIIa inhibitors: From bench to bedside and back to bench again Academic Article
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Genetic defect in N-acetylglucosaminyltransferase I gene of a ricin-resistant baby hamster kidney mutant Academic Article
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Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component Academic Article
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Gold and Silver Nanoparticles Biomimetically Synthesized Using Date Palm Pollen Extract-Induce Apoptosis and Regulate p53 and Bcl-2 Expression in Human Breast Adenocarcinoma Cells Academic Article
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Heparin assisted assembly of somatostatin amyloid nanofibrils results in disordered precipitates by hindrance of protofilaments interactions Academic Article
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High-affinity Cyclic Peptide Matriptase Inhibitors Academic Article
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High-resolution crystal structure of the reduced Grx1 from Saccharomyces cerevisiae Academic Article
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Horner-Wadsworth-Emmons approach to piperlongumine analogues with potent anti-cancer activity Academic Article
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Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA Academic Article
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Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10 Academic Article
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Identification of the binding site of apical membrane antigen 1 (AMA1) inhibitors using a paramagnetic probe Academic Article
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Identification of the peptides that inhibit the stimulation of thyrotropin receptor by Graves' immunoglobulin G from peptide libraries Academic Article
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Immunochemical characterization of two thyroid-stimulating hormone β-subunit epitopes Academic Article
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In vitro and in planta cyclization of target peptides using an asparaginyl endopeptidase from oldenlandia affinis Chapter
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Inhibition of angiotensin converting enzyme by aldehyde and ketone substrate analogs Academic Article
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Inhibition of carboxypeptidase A by ketones and alcohols that are isosteric with peptide substrates Academic Article
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Inhibition of human skin fibroblast collagenase by phosphorus-containing peptides. Academic Article
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Inhibition of the collagenase from Clostridium histolyticum by phosphoric and phosphonic amides Academic Article
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Inhibition of the elastase of Pseudomonas aeruginosa by N.alpha.-phosphoryl dipeptides and kinetics of spontaneous hydrolysis of the inhibitors Academic Article
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Inhibition of wheat embryo calcium-dependent protein kinase by acridines and azaacridines Academic Article
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Inhibitors of Metalloendopeptidase EC 3.4.24.15 and EC 3.4.24.16 Stabilized against Proteolysis by the Incorporation of β-Amino Acids Academic Article
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Insight into Schmid Metaphyseal Chondrodysplasia from the Crystal Structure of the Collagen X NC1 Domain Trimer Academic Article
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Insights into structure and function of the active site of SoxAX cytochromes Academic Article
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Introduction of a Mutation in the Shutter Region of Antithrombin (Phe77 → Leu) Increases Affinity for Heparin and Decreases Thermal Stability† Academic Article
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Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues Academic Article
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Isolation and complete amino acid sequence of a basic low molecular weight protein from black swan egg white. Academic Article
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Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B Academic Article
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Kinetic and Crystallographic Analysis of MutantEscherichia coliAminopeptidase P: Insights into Substrate Recognition and the Mechanism of Catalysis† Academic Article
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Kinetic and Structural Analysis of MutantEscherichia coliDihydroorotases: A Flexible Loop Stabilizes the Transition State†,‡ Academic Article
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Lactam-Stabilized Helical Analogues of the Analgesic μ-Conotoxin KIIIA Academic Article
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Les IAP au cœur de la signalisation NF-κB Academic Article
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Ligand release mechanisms and channels in histone deacetylases Academic Article
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M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe Academic Article
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Mannose-binding
lectin serine proteases and associated proteins of the lectin pathway of
complement: two genes, five proteins and many functions? Academic Article
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Matrix Metalloproteinase Inhibitors: A Structure−Activity Study Academic Article
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Melittin peptides exhibit different activity on different cells and model membranes Academic Article
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Mining Characteristic Relations Bind to RNA Secondary Structures Conference Paper
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Modeling Biological Activities of Nanoparticles Academic Article
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Molecular Modeling Studies of “Flap Up” Mannosyl Cation Mimics Academic Article
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Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity Academic Article
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Molecular descriptors that influence the amount of drugs transfer into human breast milk Academic Article
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Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist Academic Article
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Murine epidermal growth factor: structure and function Academic Article
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N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3 Academic Article
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N.alpha.-(O,O'-Diphenoxyphosphoryl)-L-alanyl-L-proline, N.alpha.-[O,O'-bis(4-nitrophenoxy)phosphoryl]-L-alanyl-L-proline and N.alpha.-[P-(2-phenylethyl)-O-phenoxyphosphoryl]-L-alanyl-L-proline: releasers of potent inhibitors of angiotensin converting enzyme at physiological pH and temperature Academic Article
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New 1-Aryl-3-(4-arylpiperazin-1-yl)propane Derivatives, with Dual Action at 5-HT1ASerotonin Receptors and Serotonin Transporter, as a New Class of Antidepressants Academic Article
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New Anthracenedione Derivatives with Improved Biological Activity by Virtue of Stable Drug−DNA Adduct Formation Academic Article
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Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens Academic Article
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Overexpression of Endogenous Anti-Oxidants with Selenium Supplementation Protects Trophoblast Cells from Reactive Oxygen Species-Induced Apoptosis in a Bcl-2-Dependent Manner Academic Article
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PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues Academic Article
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POPS: A COMPUTATIONAL TOOL FOR MODELING AND PREDICTING PROTEASE SPECIFICITY Academic Article
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Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides Academic Article
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Phosphatidylinositol mannosides: Synthesis and suppression of allergic airway disease Academic Article
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PoPS: a computational tool for modeling and predicting protease specificity Conference Paper
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PoPS: a computational tool for modeling and predicting protease specificity. Academic Article
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Polysaccharides Influence the Aggregation of Dictyostelium discoideum Cells and Bind to Developmentally Regulated Cell Surface Proteins Academic Article
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Positioning of the Carboxamide Side Chain in 11-Oxo-11 H -indeno[1,2- b ]quinolinecarboxamide Anticancer Agents: Effects on Cytotoxicity Academic Article
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Potent Agonists of a Hematopoietic Stem Cell Cytokine Receptor, c-Mpl Academic Article
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Potent Inhibitors of Phosphatidylinositol 3 (PI3) Kinase that have Antiproliferative Activity Only When Delivered as Prodrug Forms Academic Article
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Potential therapeutic targets and the role of technology in developing novel antileishmanial drugs Academic Article
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Probing the structure of Leishmania major DHFR TS and structure based virtual screening of peptide library for the identification of anti-leishmanial leads Academic Article
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Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite Academic Article
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Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC Academic Article
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Progress in the Development of Platelet-Activating Factor Receptor (PAFr) Antagonists and Applications in the Treatment of Inflammatory Diseases Academic Article
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Protease-responsive prodrug with aggregation-induced emission probe for controlled drug delivery and drug release tracking in living cells Academic Article
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Pulp Protection Under Restorations - Do You Need A Liner? Academic Article
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QSAR studies of hydrazone uncouplers of oxidative phosphorylation Academic Article
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Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity Academic Article
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Radiosynthesis and Biological Evaluation ofl- andd-S-(3-[18F]Fluoropropyl)homocysteine for Tumor Imaging Using Positron Emission Tomography Academic Article
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Rapid Prediction of Chemical Metabolism by Human UDP-glucuronosyltransferase Isoforms Using Quantum Chemical Descriptors Derived with the Electronegativity Equalization Method Academic Article
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Reactivity and Transformation of Antimetastatic and Cytotoxic Rhodium(III)–Dimethyl Sulfoxide Complexes in Biological Fluids: An XAS Speciation Study Academic Article
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Recent Advances in Understanding and Exploiting the Activation of Anthracyclines by Formaldehyde Academic Article
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Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V Academic Article
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Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors Academic Article
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Ribosome-inactivating proteins: Current status and biomedical applications Academic Article
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Ring-substituted 11-oxo-11 H -indeno[1,2- b ]quinoline-6-carboxamides with similar patterns of cytotoxicity to the dual topo I/II inhibitor DACA Academic Article
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Robust QSAR Models Using Bayesian Regularized Neural Networks Academic Article
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Role of the C-terminus in the activity, conformation, and stability of interleukin-6 Academic Article
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Roles of Histidine 31 and Tryptophan 34 in the Structure, Self-Association, and Folding of Murine Interleukin-6† Academic Article
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Selective Inhibition of Cyclic AMP-Dependent Protein Kinase by Isoquinoline Derivatives Academic Article
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Selective phosphinate transition-state analogue inhibitors of the protease of human immunodeficiency virus Academic Article
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Serpins in Prokaryotes Academic Article
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Serpins: Finely Balanced Conformational Traps Academic Article
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Single amino acid substititons at conserved residues of human interferon-α can effect antiviral specific activity Academic Article
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Single amino acid substitution altering antigen-binding specificity. Academic Article
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Snake venom probes of platelet adhesion receptors and their ligands Academic Article
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Strategy for the Development of a Thermodynamically Stable Oral Microemulsion Academic Article
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Structural Basis for Broad Substrate Specificity in Higher Plant β-d-Glucan Glucohydrolases Academic Article
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Structural Basis for Tetrodotoxin-resistant Sodium Channel Binding by μ-Conotoxin SmIIIA Academic Article
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Structural Determinants of Cortisol Resistance in the Guinea Pig Glucocorticoid Receptor1 Academic Article
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Structural Determinants of the Interaction between the erbB2 Receptor and the Src Homology 2 Domain of Grb7 Academic Article
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Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis Academic Article
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Structural and Biological Characterization of Murine-Human Interleukin-6 Chimeras Conference Paper
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Structural and Functional Characterization of the Oxidoreductase α-DsbA1 from Wolbachia pipientis Academic Article
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Structural and Functional Diversities among μ-Conotoxins Targeting TTX-resistant Sodium Channels† Academic Article
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Structural and functional characterization of receptor kinases with nucleotide cyclase activity Chapter
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Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis Academic Article
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Structural basis of subtilase cytotoxin SubAB assembly. Academic Article
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Structural requirements for the formation of anthracycline - DNA adducts Academic Article
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Structure and function of cyanobacterial DHDPS and DHDPR Academic Article
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Structure of Aldehyde Reductase Holoenzyme in Complex with the Potent Aldose Reductase Inhibitor Fidarestat: Implications for Inhibitor Binding and Selectivity Academic Article
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Structure of the Analgesic μ-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion†‡ Academic Article
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Structure of the T109S mutant ofEscherichia colidihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form Academic Article
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Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation Academic Article
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Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction Academic Article
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Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference Academic Article
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Structure-Function analysis of human IL-6: Identification of two distinct regions that are important for receptor binding Academic Article
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Structure-activity relations of convulsant and anticonvulsant barbiturates: a computer-graphic-based pattern-recognition analysis Academic Article
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Structure-activity relationships in quinoline reissert derivatives with hiv-1 reverse transcriptase inhibitory activity Academic Article
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Structure-based design of inhibitors of human l-xylulose reductase modelled into the active site of the enzyme Academic Article
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Structure-based drug design to augment hit discovery Academic Article
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Structure-guided design of a novel class of benzyl-sulfonate inhibitors for influenza virus neuraminidase Academic Article
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Structure-retention relationships of diuretics in reversed-phase liquid chromatography Academic Article
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Structure/Function Relationships of Apolipoprotein A-I Mimetic Peptides Academic Article
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Structure–function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins Academic Article
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Studies on 3-Deoxy-d-arabinoheptulosonate-7-phosphate Synthetase(phe) from Escherichia coli K12. 3. Structural Studies Academic Article
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Substituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists Academic Article
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Synthesis and Antitumor Properties ofN-[2-(Dimethylamino)ethyl]carboxamide Derivatives of Fused Tetracyclic Quinolines and Quinoxalines: A New Class of Putative Topoisomerase Inhibitors Academic Article
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Synthesis and Cytotoxic Activity of 7-Oxo-7H-dibenz[f,ij]isoquinoline and 7-Oxo-7H-benzo[e]perimidine Derivatives Academic Article
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Synthesis and Cytotoxic Activity of Carboxamide Derivatives of Benzo[b][1,6]naphthyridines Academic Article
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Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives Academic Article
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Synthesis and anti-inflammatory activity of indole glucosinolates Academic Article
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Synthesis and biological evaluation of 2-anilino-4-substituted-7H-pyrrolopyrimidines as PDK1 inhibitors Academic Article
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Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[ e ][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation Academic Article
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Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors Academic Article
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Synthesis and cytotoxic activity of N -(2-Diethylamino)ethylcarboxamide and other derivatives of 10 H -Quindoline Academic Article
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Synthesis and cytotoxic activity of N-[(alkylamino)alkyl]carboxamide derivatives of 7-oxo-7H-benz[de]anthracene, 7-oxo-7H-naphtho[1,2,3-de]quinoline, and 7-oxo-7H-benzo[e]perimidine Academic Article
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Synthesis and cytotoxic activity of carboxamide derivatives of benzimidazo[2,1-a]isoquinoline and pyrido [3′, 2′: 4,5] imidazo [2,1 -a] isoquinoline Academic Article
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Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridin-(5H)ones Academic Article
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Synthesis of Substituted Indeno[1,2-b]quinoline-6-carboxamides, [1]benzothieno[3,2-b]quinoline-4-carboxamides and 10H-quindoline-4-carboxamides: Evaluation of Structure–Activity Relationships for Cytotoxicity Academic Article
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Synthesis of novel 1,2,5-oxadiazoles and evaluation of action against Acinetobacter baumannii Academic Article
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Synthesis of polyamine-linked bis-daunomycin hydrazones and their interaction with DNA Academic Article
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Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines Academic Article
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Synthesis, Testing and Structure-Activity Studies on a Library of 5-HT4 Ligands Academic Article
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Synthesis, binding and bioactivity of γ-methylene γ-lactam ecdysone receptor ligands: Advantages of QSAR models for flexible receptors Academic Article
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Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines Academic Article
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Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8-and 6-aryl-substituted-1-3-benzoxazines Academic Article
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Synthesis, structure elucidation, DNA-PK, PI3K, anti-platelet and anti-bacteria activity of linear 5, 6, and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3, 4, 6-substituted-8-morpholino-chromen-oxazine-2,10-dione Academic Article
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Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5 Academic Article
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The 5′-CA DNA-sequence preference of daunomycin Academic Article
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The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation Academic Article
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The DNA-association and biological activity of a new bis(14-thiadaunomycin) Academic Article
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The Interaction of Daunomycin with Polydeoxynucleotides Academic Article
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The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition Academic Article
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The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors Academic Article
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The Role of Intracellularly Released Formaldehyde and Butyric Acid in the Anticancer Activity of Acyloxyalkyl Esters Academic Article
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The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis Academic Article
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The Three-dimensional Solution Structure of NaD1, a New Floral Defensin from Nicotiana alata and its Application to a Homology Model of the Crop Defense Protein alfAFP Academic Article
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The UBA domain of SnRK1 promotes activation and maintains catalytic activity Academic Article
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The antitumor monoclonal antibody 806 recognizes a high‐mannose form of the EGF receptor that reaches the cell surface when cells over‐express the receptor Academic Article
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The defensins consist of two independent, convergent protein superfamilies Academic Article
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The ketone cinnamoyl-(1-13C-Phe)-CGly-Pro-Pro is a tetrahedral transition state analog inhibitor of C. histolyticum collagenase Academic Article
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Tim22, the Essential Core of the Mitochondrial Protein Insertion Complex, Forms a Voltage-Activated and Signal-Gated Channel Academic Article
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Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P-falciparum and P-vivax Academic Article
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Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion Academic Article
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Use of ANN modelling in structure–retention relationships of diuretics in RP-HPLC Academic Article
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XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity Academic Article