Substrate Specificity
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Overview
subject area of
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A class of highly selective inhibitors bind to an active state of PI3K gamma Academic Article
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A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites Academic Article
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A novelin vitrosystem for simultaneous import of precursor proteins into mitochondria and chloroplasts Academic Article
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A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23 Academic Article
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A two-site model for the esterase and dehydrogenase activities of sheep liver aldehyde dehydrogenase Academic Article
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AAA+ proteins and substrate recognition, it all depends on their partner in crime Academic Article
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AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP Academic Article
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Activating Effects of GPIIb/IIIa Blockers: An Intrinsic Consequence of Ligand- Mimetic Properties Academic Article
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Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans Academic Article
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Adriamycin-induced DNA Adducts Inhibit the DNA Interactions of Transcription Factors and RNA Polymerase Academic Article
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Adriamycin-induced inhibition of mitochondrial-encoded polypeptides as a model system for the identification of hotspots for DNA-damaging agents Academic Article
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Adult and juvenile Fasciola cathepsin L proteases: Different enzymes for different roles Academic Article
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Affinity Purification, Overexpression, and Characterization of Chaperonin 10 Homologues Synthesized with and without N-terminal Acetylation Academic Article
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Aldehyde and ketone substrate analogs inhibit the collagenase of Clostridium histolyticum Academic Article
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Aldehyde dehydrogenase (ALDH) isozymes in the gray short-tailed opossum (Monodelphis domestica): Tissue and subcellular distribution and biochemical genetics of ALDH3 Academic Article
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An enzyme activity capable of endotransglycosylation of heteroxylan polysaccharides is present in plant primary cell walls Academic Article
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An exo-β-(1→3)-d-galactanase from Streptomyces sp. provides insights into type II arabinogalactan structure Academic Article
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Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1–P4 specificity reveals an unusual preference Academic Article
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Analysis of the minimal specificity of CED-3 using a yeast transcriptional reporter system Academic Article
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Approaches to Selective Peptidic Inhibitors of Factor Xa Academic Article
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Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax Academic Article
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Biochemical analysis of recombinant glutathione S-transferase of Fasciola hepatica Academic Article
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Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1 Academic Article
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Biochemical genetics of alcohol dehydrogenase isozymes in the gray short-tailed opossum (Monodelphis domestica) Academic Article
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Bioinformatic approaches for predicting substrates of proteases Academic Article
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Bradykinin analogues with ?-amino acid substitutions reveal subtle differences in substrate specificity between the endopeptidases EC 3.4.24.15 and EC 3.4.24.16 Academic Article
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Broad yet high substrate specificity: the challenge of AAA+ proteins Academic Article
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CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity Academic Article
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Caspase Proteolysis of the Cohesin Component RAD21 Promotes Apoptosis Academic Article
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Caspase-2: controversial killer or checkpoint controller? Academic Article
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Caspase-8 Cleaves Histone Deacetylase 7 and Abolishes Its Transcription Repressor Function Academic Article
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Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis Academic Article
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Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus Academic Article
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Characterization of a Serine Protease Homologous to House Dust Mite Group 3 Allergens from the Scabies MiteSarcoptes scabiei Academic Article
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Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization Academic Article
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Characterization of the Specificity of Arginine-Specific Gingipains fromPorphyromonas gingivalisReveals Active Site Differences between Different Forms of the Enzymes† Academic Article
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Cleavage of proteoglycan aggregate by leucocyte elastase Academic Article
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Cloning and characterization of AtNUDT13, a novel mitochondrial Arabidopsis thaliana Nudix hydrolase specific for long-chain diadenosine polyphosphates Academic Article
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Cloning and expression of the recombinant mouse natural killer cell granzymeMet-ase-1 Academic Article
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ClpS is an essential component of the N-end rule pathway in Escherichia coli Academic Article
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ClpS, a Substrate Modulator of the ClpAP Machine Academic Article
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Complex demethylation patterns at Sp1 binding sites in F9 embryonal carcinoma cells Academic Article
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Concurrent Binding of Anti-EphA3 Antibody and Ephrin-A5 Amplifies EphA3 Signaling and Downstream Responses: Potential as EphA3-Specific Tumor-Targeting Reagents Academic Article
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Conformational energy calculations and electrostatic potentials of dihydrofolate reductase ligands: relevance to mode of binding and species specificity Academic Article
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Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding Academic Article
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Cooperative effects in the substrate specificity of the complement protease C1s Academic Article
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Crystal Structure and Comparative Functional Analyses of a Mycobacterium Aldo-Keto Reductase Academic Article
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Crystal Structure of a UDP-glucose-specific Glycosyltransferase from aMycobacterium Species Academic Article
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Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase fromClostridium botulinumin the presence of its substrate pyruvate Academic Article
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Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase 1 1Edited by R. Huber Academic Article
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DRONC, an ecdysone-inducible Drosophila caspase Academic Article
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Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors Academic Article
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Design and synthesis of inhibitors incorporating ?-amino acids of metalloendopeptidase EC 3.4.24.15 Academic Article
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Design of potential anti-HIV agents. 1. Mannosidase inhibitors Academic Article
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Detection of two loci involved in (1->3)- -glucan (curdlan) biosynthesis by Agrobacterium sp. ATCC31749, and comparative sequence analysis of the putative curdlan synthase gene Academic Article
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Determination of the P1′, P2′ and P3′ subsite-specificity of factor Xa Academic Article
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Directed Formation of Micro- and Nanoscale Patterns of Functional Light-Harvesting LH2 Complexes Academic Article
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Discovery of amino acid motifs for Thrombin Cleavage and validation using a model substrate Academic Article
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Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine Academic Article
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Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase Academic Article
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Dynamic modelling reveals 'hotspots' on the pathway to enzyme-substrate complex formation Academic Article
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Elucidation of the Substrate Specificity of the C1s Protease of the Classical Complement Pathway Academic Article
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Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor Academic Article
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Enzymatic Properties of an Ecto-nucleoside Triphosphate Diphosphohydrolase fromLegionella pneumophila Academic Article
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Enzymatic hydrolysis of enterochelin and its iron complex in Escherichia coli K-12. Properties of enterochelin esterase Academic Article
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Evolution of Quaternary Structure in a Homotetrameric Enzyme Academic Article
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Evolution of Serpin Specificity: Cooperative Interactions in the Reactive-Site Loop Sequence of Antithrombin Specifically Restrict the Inhibition of Activated Protein C Academic Article
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Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase fromBacillus anthracisin the presence of pyruvate Academic Article
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Fasciola hepatica: Characterization and Cloning of the Major Cathepsin B Protease Secreted by Newly Excysted Juvenile Liver Fluke Academic Article
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For the record: A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica Academic Article
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GPVI and GPIbα Mediate Staphylococcal Superantigen-Like Protein 5 (SSL5) Induced Platelet Activation and Direct toward Glycans as Potential Inhibitors Academic Article
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Genomic and functional characterization of the oas gene family encoding O-acetylserine (thiol) lyases, enzymes catalyzing the final step in cysteine biosynthesis in Arabidopsis thaliana Academic Article
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High-Contrast PET of Melanoma Using 18F-MEL050, a Selective Probe for Melanin with Predominantly Renal Clearance Academic Article
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High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor Academic Article
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High-resolution crystal structure of the reduced Grx1 from Saccharomyces cerevisiae Academic Article
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Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones Academic Article
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Hydrolysis of α-d-glucans and α-d-gluco-oligosaccharides by cladosporium resinae glucoamylases Academic Article
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Identification of a novel group of putative Arabidopsis thaliana β-(1,3)-galactosyltransferases Academic Article
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Identification of cis-regulatory elements specific for different types of reactive oxygen species in Arabidopsis thaliana Academic Article
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Importance of the Prime Subsites of the C1s Protease of the Classical Complement Pathway for Recognition of Substrates† Academic Article
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In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins Academic Article
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Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin Academic Article
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Inhibition of angiotensin converting enzyme by aldehyde and ketone substrate analogs Academic Article
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Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors Academic Article
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Inhibition of wheat embryo calcium-dependent protein kinase by acridines and azaacridines Academic Article
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KSIMC: Predicting kinase–Substrate interactions based on matrix completion Academic Article
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Kinetic and Crystallographic Analysis of MutantEscherichia coliAminopeptidase P: Insights into Substrate Recognition and the Mechanism of Catalysis† Academic Article
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Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins Academic Article
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Mammalian initiator apoptotic caspases Academic Article
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Mature DIABLO/Smac Is Produced by the IMP Protease Complex on the Mitochondrial Inner Membrane Academic Article
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Metabolism of 17?-Estradiol and the Adrenal-Derived Estrogen 5-Androstene-3?, 17?-Diol (Hermaphrodiol) in Human Mammary Cell Lines Academic Article
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Methionine-Oxidized Amyloid Fibrils Are Poor Substrates for Human Methionine Sulfoxide Reductases A and B2 Academic Article
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Mining a Tandem Mass Spectrometry Database To Determine the Trends and Global Factors Influencing Peptide Fragmentation Academic Article
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Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON-mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA Academic Article
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Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli Academic Article
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Molecular Determinants of the Substrate Specificity of the Complement-initiating Protease, C1r Academic Article
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Molecular basis for the folding of β-helical autotransporter passenger domains Academic Article
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Mutagenesis and computer modelling approach to study determinants for recognition of signal peptides by the mitochondrial processing peptidase Academic Article
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Mutating the Tight-Dimer Interface of Dihydrodipicolinate Synthase Disrupts the Enzyme Quaternary Structure: Toward a Monomeric Enzyme†‡ Academic Article
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New insights into the mechanism of dihydrodipicolinate synthase using isothermal titration calorimetry Academic Article
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Noncellulolytic fungal β-glucanases: Their physiology and regulation Academic Article
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Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins Academic Article
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Organic acid activation of the alterNatlve oxidase of plant mitochondria Academic Article
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Oxidation of organic and biogenic amines by recombinant human hephaestin expressed in Pichia pastoris Academic Article
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POPS: A COMPUTATIONAL TOOL FOR MODELING AND PREDICTING PROTEASE SPECIFICITY Academic Article
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PROSPER: An Integrated Feature-Based Tool for Predicting Protease Substrate Cleavage Sites Academic Article
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PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy Academic Article
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Phosphorylation of glycogen synthase by the Ca2+- and phospholipid-activated protein kinase (protein kinase C) Academic Article
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PoPS: a computational tool for modeling and predicting protease specificity Conference Paper
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PoPS: a computational tool for modeling and predicting protease specificity. Academic Article
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Post-Translational Processing of Barley β-Glucan Endohydrolases in the Baculovirus–Insect Cell Expression System Academic Article
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Predicting serpin/protease interactions Academic Article
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Protein unfolding is essential for cleavage within the alpha-helix of a model protein substrate by the serine protease, thrombin Academic Article
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Proteolytically active complexes of cathepsin L and a cysteine proteinase inhibitor; purification and demonstration of their formation in vitro Academic Article
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Pupylation of PafA or Pup inhibits components of the Pup-Proteasome system Academic Article
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Purification and Characterization of a 43-kDa Rotenone-insensitive NADH Dehydrogenase from Plant Mitochondria Academic Article
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Purification and Characterization of a Novel Endopeptidase in Ragweed (Ambrosia artemisiifolia) Pollen Academic Article
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Purification and analysis of an extremely halophilic β-galactosidase from Haloferax alicantei Academic Article
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Purification and characterization of an extracellular (1 → 6)-β-glucanase from the filamentous fungus Acremonium persicinum Academic Article
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Purification and characterization of an extracellular β-glucosidase from the filamentous fungus Acremonium persicinum and its probable role in β-glucan degradation Academic Article
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Purification and characterization of three extracellular (1→3)-β-d-glucan glucohydrolases from the filamentous fungus Acremonium persicinum Academic Article
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Rapid Optimization of a Peptide Inhibitor of Malaria Parasite Invasion by ComprehensiveN-Methyl Scanning Academic Article
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Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures Academic Article
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Sequence specificity and reactivity of the binding of phenazine-tethered platinum complexes to DNA Academic Article
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Site-directed mutagenesis of Arg60 and Cys271 in ornithine transcarbamylase from rat liver Academic Article
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Solubilisation and reconstitution of acylcoenzyme A:estradiol-17β acyltransferase Academic Article
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Specificity and mutational analysis of the metal-dependent 3-deoxy-d-manno-octulosonate 8-phosphate synthase from Acidithiobacillus ferrooxidans Academic Article
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Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis Academic Article
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Structural Basis for Broad Substrate Specificity in Higher Plant β-d-Glucan Glucohydrolases Academic Article
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Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target Academic Article
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Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA Academic Article
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Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 fromNeisseria meningitidis Academic Article
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Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase Academic Article
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Structural and Functional Characterization of the PaaI Thioesterase from Streptococcus pneumoniae Reveals a Dual Specificity for Phenylacetyl-CoA and Medium-chain Fatty Acyl-CoAs and a Novel CoA-induced Fit Mechanism Academic Article
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Structural and functional characterization of TesB from Yersinia pestis reveals a unique octameric arrangement of hotdog domains Academic Article
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Structural basis for plasmep sin V inhibition that blocks export of malaria proteins to human erythrocytes Academic Article
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Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase Academic Article
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Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase Academic Article
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Structure and mechanism of a sub-family of enzymes related to N -acetylneuraminate lyase 1 1Edited by F. E. Cohen Academic Article
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Structure of the T109S mutant ofEscherichia colidihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form Academic Article
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Structure-Activity Relationships for Serotonin Transporter and Dopamine Receptor Selectivity Academic Article
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Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference Academic Article
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Subcellular localization and tissue specific expression of amidase 1 from Arabidopsis thaliana Academic Article
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Subsite cooperativity in protease specificity Academic Article
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Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX Academic Article
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Synthesis and preliminary screening of novel indole-3-methanamines as 5-HT4 receptor ligands Academic Article
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Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands Academic Article
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Targeting the Role of a Key Conserved Motif for Substrate Selection and Catalysis by 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthase Academic Article
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The Evolution of Enzyme Specificity in Fasciola spp. Academic Article
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The Initiation of GTP Hydrolysis by the G-Domain of FeoB: Insights from a Transition-State Complex Structure Academic Article
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The Junction-associated Protein AF-6 Interacts and Clusters with Specific Eph Receptor Tyrosine Kinases at Specialized Sites of Cell–Cell Contact in the Brain Academic Article
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The LS locus of pea encodes the gibberellin biosynthesis enzyme ent-kaurene synthase A Academic Article
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The N-end rule adaptor protein ClpS from Plasmodium falciparum exhibits broad substrate specificity Academic Article
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The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes Academic Article
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The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates Academic Article
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The Three Members of the Arabidopsis Glycosyltransferase Family 92 are Functional β-1,4-Galactan Synthases Academic Article
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The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome Academic Article
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The active site specificity of angiotensin II converting enzyme 2 investigated through single and multiple residue changes and β-amino acid substrate analogs. Academic Article
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The effects of exosite occupancy on the substrate specificity of thrombin Academic Article
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The ketone cinnamoyl-(1-13C-Phe)-CGly-Pro-Pro is a tetrahedral transition state analog inhibitor of C. histolyticum collagenase Academic Article
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The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain Academic Article
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The purification of a Rap1 GTPase-activating protein from bovine brain cytosol Academic Article
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The structure and activity of the glutathione reductase from Streptococcus pneumoniae Academic Article
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Titration and Mapping of the Active Site of Cysteine Proteinases from Porphyromonas gingivalis (Gingipains) Using Peptidyl Chloromethanes Academic Article
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Transforming a Fructan:Fructan 6G-Fructosyltransferase from Perennial Ryegrass into a Sucrose:Sucrose 1-Fructosyltransferase Academic Article
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Transport of Neutral Amino Acids by Adult Articular Cartilage Academic Article
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X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP Academic Article