subject area of

• A class of highly selective inhibitors bind to an active state of PI3K gamma  Academic Article
• A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites  Academic Article
• A novelin vitrosystem for simultaneous import of precursor proteins into mitochondria and chloroplasts  Academic Article
• A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23  Academic Article
• A two-site model for the esterase and dehydrogenase activities of sheep liver aldehyde dehydrogenase  Academic Article
• AAA+ proteins and substrate recognition, it all depends on their partner in crime  Academic Article
• AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP  Academic Article
• Activating Effects of GPIIb/IIIa Blockers: An Intrinsic Consequence of Ligand- Mimetic Properties  Academic Article
• Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans  Academic Article
• Adriamycin-induced DNA Adducts Inhibit the DNA Interactions of Transcription Factors and RNA Polymerase  Academic Article
• Adriamycin-induced inhibition of mitochondrial-encoded polypeptides as a model system for the identification of hotspots for DNA-damaging agents  Academic Article
• Adult and juvenile Fasciola cathepsin L proteases: Different enzymes for different roles  Academic Article
• Affinity Purification, Overexpression, and Characterization of Chaperonin 10 Homologues Synthesized with and without N-terminal Acetylation  Academic Article
• Aldehyde and ketone substrate analogs inhibit the collagenase of Clostridium histolyticum  Academic Article
• Aldehyde dehydrogenase (ALDH) isozymes in the gray short-tailed opossum (Monodelphis domestica): Tissue and subcellular distribution and biochemical genetics of ALDH3  Academic Article
• An enzyme activity capable of endotransglycosylation of heteroxylan polysaccharides is present in plant primary cell walls  Academic Article
• An exo-β-(1→3)-d-galactanase from Streptomyces sp. provides insights into type II arabinogalactan structure  Academic Article
• Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1–P4 specificity reveals an unusual preference  Academic Article
• Analysis of the minimal specificity of CED-3 using a yeast transcriptional reporter system  Academic Article
• Approaches to Selective Peptidic Inhibitors of Factor Xa  Academic Article
• Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax  Academic Article
• Biochemical analysis of recombinant glutathione S-transferase of Fasciola hepatica  Academic Article
• Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1  Academic Article
• Biochemical genetics of alcohol dehydrogenase isozymes in the gray short-tailed opossum (Monodelphis domestica)  Academic Article
• Bioinformatic approaches for predicting substrates of proteases  Academic Article
• Bradykinin analogues with ?-amino acid substitutions reveal subtle differences in substrate specificity between the endopeptidases EC 3.4.24.15 and EC 3.4.24.16  Academic Article
• Broad yet high substrate specificity: the challenge of AAA+ proteins  Academic Article
• CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity  Academic Article
• Caspase Proteolysis of the Cohesin Component RAD21 Promotes Apoptosis  Academic Article
• Caspase-2: controversial killer or checkpoint controller?  Academic Article
• Caspase-8 Cleaves Histone Deacetylase 7 and Abolishes Its Transcription Repressor Function  Academic Article
• Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis  Academic Article
• Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus  Academic Article
• Characterization of a Serine Protease Homologous to House Dust Mite Group 3 Allergens from the Scabies MiteSarcoptes scabiei  Academic Article
• Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization  Academic Article
• Characterization of the Specificity of Arginine-Specific Gingipains fromPorphyromonas gingivalisReveals Active Site Differences between Different Forms of the Enzymes†  Academic Article
• Cleavage of proteoglycan aggregate by leucocyte elastase  Academic Article
• Cloning and characterization of AtNUDT13, a novel mitochondrial Arabidopsis thaliana Nudix hydrolase specific for long-chain diadenosine polyphosphates  Academic Article
• Cloning and expression of the recombinant mouse natural killer cell granzymeMet-ase-1  Academic Article
• ClpS is an essential component of the N-end rule pathway in Escherichia coli  Academic Article
• ClpS, a Substrate Modulator of the ClpAP Machine  Academic Article
• Complex demethylation patterns at Sp1 binding sites in F9 embryonal carcinoma cells  Academic Article
• Concurrent Binding of Anti-EphA3 Antibody and Ephrin-A5 Amplifies EphA3 Signaling and Downstream Responses: Potential as EphA3-Specific Tumor-Targeting Reagents  Academic Article
• Conformational energy calculations and electrostatic potentials of dihydrofolate reductase ligands: relevance to mode of binding and species specificity  Academic Article
• Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding  Academic Article
• Cooperative effects in the substrate specificity of the complement protease C1s  Academic Article
• Crystal Structure and Comparative Functional Analyses of a Mycobacterium Aldo-Keto Reductase  Academic Article
• Crystal Structure of a UDP-glucose-specific Glycosyltransferase from aMycobacterium Species  Academic Article
• Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase fromClostridium botulinumin the presence of its substrate pyruvate  Academic Article
• Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase 1 1Edited by R. Huber  Academic Article
• DRONC, an ecdysone-inducible Drosophila caspase  Academic Article
• Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors  Academic Article
• Design and synthesis of inhibitors incorporating ?-amino acids of metalloendopeptidase EC 3.4.24.15  Academic Article
• Design of potential anti-HIV agents. 1. Mannosidase inhibitors  Academic Article
• Detection of two loci involved in (1->3)- -glucan (curdlan) biosynthesis by Agrobacterium sp. ATCC31749, and comparative sequence analysis of the putative curdlan synthase gene  Academic Article
• Determination of the P1′, P2′ and P3′ subsite-specificity of factor Xa  Academic Article
• Directed Formation of Micro- and Nanoscale Patterns of Functional Light-Harvesting LH2 Complexes  Academic Article
• Discovery of amino acid motifs for Thrombin Cleavage and validation using a model substrate  Academic Article
• Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine  Academic Article
• Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase  Academic Article
• Dynamic modelling reveals 'hotspots' on the pathway to enzyme-substrate complex formation  Academic Article
• Elucidation of the Substrate Specificity of the C1s Protease of the Classical Complement Pathway  Academic Article
• Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor  Academic Article
• Enzymatic Properties of an Ecto-nucleoside Triphosphate Diphosphohydrolase fromLegionella pneumophila  Academic Article
• Enzymatic hydrolysis of enterochelin and its iron complex in Escherichia coli K-12. Properties of enterochelin esterase  Academic Article
• Evolution of Quaternary Structure in a Homotetrameric Enzyme  Academic Article
• Evolution of Serpin Specificity: Cooperative Interactions in the Reactive-Site Loop Sequence of Antithrombin Specifically Restrict the Inhibition of Activated Protein C  Academic Article
• Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase fromBacillus anthracisin the presence of pyruvate  Academic Article
• Fasciola hepatica: Characterization and Cloning of the Major Cathepsin B Protease Secreted by Newly Excysted Juvenile Liver Fluke  Academic Article
• For the record: A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica  Academic Article
• GPVI and GPIbα Mediate Staphylococcal Superantigen-Like Protein 5 (SSL5) Induced Platelet Activation and Direct toward Glycans as Potential Inhibitors  Academic Article
• Genomic and functional characterization of the oas gene family encoding O-acetylserine (thiol) lyases, enzymes catalyzing the final step in cysteine biosynthesis in Arabidopsis thaliana  Academic Article
• High-Contrast PET of Melanoma Using 18F-MEL050, a Selective Probe for Melanin with Predominantly Renal Clearance  Academic Article
• High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat:  Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor  Academic Article
• High-resolution crystal structure of the reduced Grx1 from Saccharomyces cerevisiae  Academic Article
• Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones  Academic Article
• Hydrolysis of α-d-glucans and α-d-gluco-oligosaccharides by cladosporium resinae glucoamylases  Academic Article
• Identification of a novel group of putative Arabidopsis thaliana β-(1,3)-galactosyltransferases  Academic Article
• Identification of cis-regulatory elements specific for different types of reactive oxygen species in Arabidopsis thaliana  Academic Article
• Importance of the Prime Subsites of the C1s Protease of the Classical Complement Pathway for Recognition of Substrates†  Academic Article
• In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins  Academic Article
• Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin  Academic Article
• Inhibition of angiotensin converting enzyme by aldehyde and ketone substrate analogs  Academic Article
• Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors  Academic Article
• Inhibition of wheat embryo calcium-dependent protein kinase by acridines and azaacridines  Academic Article
• KSIMC: Predicting kinase–Substrate interactions based on matrix completion  Academic Article
• Kinetic and Crystallographic Analysis of MutantEscherichia coliAminopeptidase P:  Insights into Substrate Recognition and the Mechanism of Catalysis†  Academic Article
• Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins  Academic Article
• Mammalian initiator apoptotic caspases  Academic Article
• Mature DIABLO/Smac Is Produced by the IMP Protease Complex on the Mitochondrial Inner Membrane  Academic Article
• Metabolism of 17?-Estradiol and the Adrenal-Derived Estrogen 5-Androstene-3?, 17?-Diol (Hermaphrodiol) in Human Mammary Cell Lines  Academic Article
• Methionine-Oxidized Amyloid Fibrils Are Poor Substrates for Human Methionine Sulfoxide Reductases A and B2  Academic Article
• Mining a Tandem Mass Spectrometry Database To Determine the Trends and Global Factors Influencing Peptide Fragmentation  Academic Article
• Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON-mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA  Academic Article
• Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli  Academic Article
• Molecular Determinants of the Substrate Specificity of the Complement-initiating Protease, C1r  Academic Article
• Molecular basis for the folding of β-helical autotransporter passenger domains  Academic Article
• Mutagenesis and computer modelling approach to study determinants for recognition of signal peptides by the mitochondrial processing peptidase  Academic Article
• Mutating the Tight-Dimer Interface of Dihydrodipicolinate Synthase Disrupts the Enzyme Quaternary Structure: Toward a Monomeric Enzyme†‡  Academic Article
• New insights into the mechanism of dihydrodipicolinate synthase using isothermal titration calorimetry  Academic Article
• Noncellulolytic fungal β-glucanases: Their physiology and regulation  Academic Article
• Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins  Academic Article
• Organic acid activation of the alterNatlve oxidase of plant mitochondria  Academic Article
• Oxidation of organic and biogenic amines by recombinant human hephaestin expressed in Pichia pastoris  Academic Article
• POPS: A COMPUTATIONAL TOOL FOR MODELING AND PREDICTING PROTEASE SPECIFICITY  Academic Article
• PROSPER: An Integrated Feature-Based Tool for Predicting Protease Substrate Cleavage Sites  Academic Article
• PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy  Academic Article
• Phosphorylation of glycogen synthase by the Ca²⁺- and phospholipid-activated protein kinase (protein kinase C)  Academic Article
• PoPS: a computational tool for modeling and predicting protease specificity  Conference Paper
• PoPS: a computational tool for modeling and predicting protease specificity.  Academic Article
• Post-Translational Processing of Barley β-Glucan Endohydrolases in the Baculovirus–Insect Cell Expression System  Academic Article
• Predicting serpin/protease interactions  Academic Article
• Protein unfolding is essential for cleavage within the alpha-helix of a model protein substrate by the serine protease, thrombin  Academic Article
• Proteolytically active complexes of cathepsin L and a cysteine proteinase inhibitor; purification and demonstration of their formation in vitro  Academic Article
• Pupylation of PafA or Pup inhibits components of the Pup-Proteasome system  Academic Article
• Purification and Characterization of a 43-kDa Rotenone-insensitive NADH Dehydrogenase from Plant Mitochondria  Academic Article
• Purification and Characterization of a Novel Endopeptidase in Ragweed (Ambrosia artemisiifolia) Pollen  Academic Article
• Purification and analysis of an extremely halophilic β-galactosidase from Haloferax alicantei  Academic Article
• Purification and characterization of an extracellular (1 → 6)-β-glucanase from the filamentous fungus Acremonium persicinum  Academic Article
• Purification and characterization of an extracellular β-glucosidase from the filamentous fungus Acremonium persicinum and its probable role in β-glucan degradation  Academic Article
• Purification and characterization of three extracellular (1→3)-β-d-glucan glucohydrolases from the filamentous fungus Acremonium persicinum  Academic Article
• Rapid Optimization of a Peptide Inhibitor of Malaria Parasite Invasion by ComprehensiveN-Methyl Scanning  Academic Article
• Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures  Academic Article
• Sequence specificity and reactivity of the binding of phenazine-tethered platinum complexes to DNA  Academic Article
• Site-directed mutagenesis of Arg60 and Cys271 in ornithine transcarbamylase from rat liver  Academic Article
• Solubilisation and reconstitution of acylcoenzyme A:estradiol-17β acyltransferase  Academic Article
• Specificity and mutational analysis of the metal-dependent 3-deoxy-d-manno-octulosonate 8-phosphate synthase from Acidithiobacillus ferrooxidans  Academic Article
• Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis  Academic Article
• Structural Basis for Broad Substrate Specificity in Higher Plant β-d-Glucan Glucohydrolases  Academic Article
• Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target  Academic Article
• Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA  Academic Article
• Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 fromNeisseria meningitidis  Academic Article
• Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase  Academic Article
• Structural and Functional Characterization of the PaaI Thioesterase from Streptococcus pneumoniae Reveals a Dual Specificity for Phenylacetyl-CoA and Medium-chain Fatty Acyl-CoAs and a Novel CoA-induced Fit Mechanism  Academic Article
• Structural and functional characterization of TesB from Yersinia pestis reveals a unique octameric arrangement of hotdog domains  Academic Article
• Structural basis for plasmep sin V inhibition that blocks export of malaria proteins to human erythrocytes  Academic Article
• Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase  Academic Article
• Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase  Academic Article
• Structure and mechanism of a sub-family of enzymes related to N -acetylneuraminate lyase 1 1Edited by F. E. Cohen  Academic Article
• Structure of the T109S mutant ofEscherichia colidihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form  Academic Article
• Structure-Activity Relationships for Serotonin Transporter and Dopamine Receptor Selectivity  Academic Article
• Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference  Academic Article
• Subcellular localization and tissue specific expression of amidase 1 from Arabidopsis thaliana  Academic Article
• Subsite cooperativity in protease specificity  Academic Article
• Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX  Academic Article
• Synthesis and preliminary screening of novel indole-3-methanamines as 5-HT4 receptor ligands  Academic Article
• Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands  Academic Article
• Targeting the Role of a Key Conserved Motif for Substrate Selection and Catalysis by 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthase  Academic Article
• The Evolution of Enzyme Specificity in Fasciola spp.  Academic Article
• The Initiation of GTP Hydrolysis by the G-Domain of FeoB: Insights from a Transition-State Complex Structure  Academic Article
• The Junction-associated Protein AF-6 Interacts and Clusters with Specific Eph Receptor Tyrosine Kinases at Specialized Sites of Cell–Cell Contact in the Brain  Academic Article
• The LS locus of pea encodes the gibberellin biosynthesis enzyme ent-kaurene synthase A  Academic Article
• The N-end rule adaptor protein ClpS from Plasmodium falciparum exhibits broad substrate specificity  Academic Article
• The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes  Academic Article
• The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates  Academic Article
• The Three Members of the Arabidopsis Glycosyltransferase Family 92 are Functional β-1,4-Galactan Synthases  Academic Article
• The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome  Academic Article
• The active site specificity of angiotensin II converting enzyme 2 investigated through single and multiple residue changes and β-amino acid substrate analogs.  Academic Article
• The effects of exosite occupancy on the substrate specificity of thrombin  Academic Article
• The ketone cinnamoyl-(1-13C-Phe)-CGly-Pro-Pro is a tetrahedral transition state analog inhibitor of C. histolyticum collagenase  Academic Article
• The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain  Academic Article
• The purification of a Rap1 GTPase-activating protein from bovine brain cytosol  Academic Article
• The structure and activity of the glutathione reductase from Streptococcus pneumoniae  Academic Article
• Titration and Mapping of the Active Site of Cysteine Proteinases from Porphyromonas gingivalis (Gingipains) Using Peptidyl Chloromethanes  Academic Article
• Transforming a Fructan:Fructan 6G-Fructosyltransferase from Perennial Ryegrass into a Sucrose:Sucrose 1-Fructosyltransferase  Academic Article
• Transport of Neutral Amino Acids by Adult Articular Cartilage  Academic Article
• X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP  Academic Article