Sulfonamides
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A Novel Histone Deacetylase Inhibitor Reduces Abdominal Aortic Aneurysm Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice Academic Article
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A phase Ib dose-escalation and expansion study of the BCL2 inhibitor nenetoclax combined with tamoxifen in ER and BCL2–positive metastatic breast cancer Academic Article
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ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin–DNA adducts Academic Article
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ABT-737, proving to be a great tool even before it is proven in the clinic Academic Article
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Activation of Liver X Receptor Decreases Atherosclerosis in Ldlr-/- Mice in the Absence of ATP-Binding Cassette Transporters A1 and G1 in Myeloid Cells Academic Article
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Antibiotic prescribing during an outbreak of meningococcal disease Academic Article
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BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux Academic Article
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BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival Academic Article
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BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines Academic Article
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BRAF V600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells Academic Article
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Bcl-2, Bcl-x L, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells Academic Article
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Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic Academic Article
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Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199 Academic Article
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CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex. Academic Article
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Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon Academic Article
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Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands Academic Article
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Correlation of the impedance and effective electrode area of doped PEDOT modified electrodes for brain-machine interfaces Academic Article
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Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family Academic Article
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Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors Academic Article
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Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes Academic Article
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Early-Life Exposure to Oral Antibiotics and Lung Function Into Early Adulthood Academic Article
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Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres Academic Article
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Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics Academic Article
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Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM Academic Article
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Identification of the binding site of apical membrane antigen 1 (AMA1) inhibitors using a paramagnetic probe Academic Article
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Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca
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/Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway Academic Article
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Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells Academic Article
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Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites Academic Article
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Intercellular Resistance to BRAF Inhibition Can Be Mediated by Extracellular Vesicle–Associated PDGFRβ1 Academic Article
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Intrastriatal injection of endothelin evokes dopaminergic turning behaviour in rats through activation of the ETB receptor Academic Article
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Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival Academic Article
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Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins Academic Article
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Mutation to bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis Academic Article
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Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity Academic Article
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Novel inhibitors of urokinase-type plasminogen activator and matrix metalloproteinase expression in metastatic cancer cell lines Academic Article
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PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation Academic Article
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PYL8 mediates ABA perception in the root through non-cell-autonomous and ligand-stabilization–based mechanisms Academic Article
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Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides Academic Article
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Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage and dysfunction in salt-sensitive hypertension. Academic Article
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Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma Academic Article
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Pre-clinical evaluation of proteasome inhibitors for canine and human osteosarcoma Academic Article
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Preparing samples for crystallization of Bcl-2 family complexes Chapter
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Prion infection impairs cholesterol metabolism in neuronal cells Academic Article
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Programmed Anuclear Cell Death Delimits Platelet Life Span Academic Article
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Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak Academic Article
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Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity Academic Article
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Reno-Protective Effects of TAK-242 on Acute Kidney Injury in a Rat Model Academic Article
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Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents Academic Article
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Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP Academic Article
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Subversion of the Bcl-2 Life/Death Switch in Cancer Development and Therapy Conference Paper
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Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer Academic Article
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Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer Academic Article
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Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure Academic Article
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The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia Academic Article
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Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies Academic Article
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Tomato PYR/PYL/RCAR abscisic acid receptors show high expression in root, differential sensitivity to the abscisic acid agonist quinabactin, and the capability to enhance plant drought resistance Academic Article
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Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands Academic Article
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Yeast techniques for modeling drugs targeting Bcl-2 and caspase family members Academic Article