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• A Novel Histone Deacetylase Inhibitor Reduces Abdominal Aortic Aneurysm Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice  Academic Article
• A phase Ib dose-escalation and expansion study of the BCL2 inhibitor nenetoclax combined with tamoxifen in ER and BCL2–positive metastatic breast cancer  Academic Article
• ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin–DNA adducts  Academic Article
• ABT-737, proving to be a great tool even before it is proven in the clinic  Academic Article
• Activation of Liver X Receptor Decreases Atherosclerosis in Ldlr-/- Mice in the Absence of ATP-Binding Cassette Transporters A1 and G1 in Myeloid Cells  Academic Article
• Antibiotic prescribing during an outbreak of meningococcal disease  Academic Article
• BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux  Academic Article
• BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival  Academic Article
• BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines  Academic Article
• BRAF V600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells  Academic Article
• Bcl-2, Bcl-x L, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells  Academic Article
• Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic  Academic Article
• Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199  Academic Article
• CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.  Academic Article
• Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon  Academic Article
• Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands  Academic Article
• Correlation of the impedance and effective electrode area of doped PEDOT modified electrodes for brain-machine interfaces  Academic Article
• Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family  Academic Article
• Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors  Academic Article
• Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes  Academic Article
• Early-life exposure to oral antibiotics and lung function into early adulthood  Academic Article
• Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres  Academic Article
• Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics  Academic Article
• Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM  Academic Article
• Identification of the binding site of apical membrane antigen 1 (AMA1) inhibitors using a paramagnetic probe  Academic Article
• Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca 2+ /Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway  Academic Article
• Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells  Academic Article
• Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites  Academic Article
• Inhibition of heat shock protein 70 blocks the development of cardiac hypertrophy by modulating the phosphorylation of histone deacetylase 2  Academic Article
• Intercellular Resistance to BRAF Inhibition Can Be Mediated by Extracellular Vesicle–Associated PDGFRβ1  Academic Article
• Intrastriatal injection of endothelin evokes dopaminergic turning behaviour in rats through activation of the ETB receptor  Academic Article
• Low-Intensity Pulsed Ultrasound Accelerates and a Nonsteroidal Anti-inflammatory Drug Delays Knee Ligament Healing  Academic Article
• Low-intensity pulsed ultrasound and nonsteroidal anti-inflammatory drugs have opposing effects during stress fracture repair  Academic Article
• Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival  Academic Article
• Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins  Academic Article
• Mutation to bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis  Academic Article
• Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity  Academic Article
• Novel inhibitors of urokinase-type plasminogen activator and matrix metalloproteinase expression in metastatic cancer cell lines  Academic Article
• PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation  Academic Article
• PYL8 mediates ABA perception in the root through non-cell-autonomous and ligand-stabilization–based mechanisms  Academic Article
• Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides  Academic Article
• Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage and dysfunction in salt-sensitive hypertension.  Academic Article
• Pre-clinical evaluation of proteasome inhibitors for canine and human osteosarcoma  Academic Article
• Preparing samples for crystallization of Bcl-2 family complexes  Chapter
• Prion infection impairs cholesterol metabolism in neuronal cells  Academic Article
• Programmed Anuclear Cell Death Delimits Platelet Life Span  Academic Article
• Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak  Academic Article
• Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity  Academic Article
• Reno-Protective Effects of TAK-242 on Acute Kidney Injury in a Rat Model  Academic Article
• Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents  Academic Article
• Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP  Academic Article
• Subversion of the Bcl-2 Life/Death Switch in Cancer Development and Therapy  Conference Paper
• Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer  Academic Article
• Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer  Academic Article
• Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure  Academic Article
• The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia  Academic Article
• Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies  Academic Article
• Tomato PYR/PYL/RCAR abscisic acid receptors show high expression in root, differential sensitivity to the abscisic acid agonist quinabactin, and the capability to enhance plant drought resistance  Academic Article
• Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands  Academic Article
• Yeast techniques for modeling drugs targeting Bcl-2 and caspase family members  Academic Article